Search Results - "Quenelle, Debra"

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes by Hill, James M, Quenelle, Debra C, Cardin, Rhonda D, Vogel, Jodi L, Clement, Christian, Bravo, Fernando J, Foster, Timothy P, Bosch-Marce, Marta, Raja, Priya, Lee, Jennifer S, Bernstein, David I, Krause, Philip R, Knipe, David M, Kristie, Thomas M

“…Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability…”
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A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency by Liang, Yu, Quenelle, Debra, Vogel, Jodi L, Mascaro, Cristina, Ortega, Alberto, Kristie, Thomas M

“…Cellular processes requiring access to the DNA genome are regulated by an overlay of epigenetic modifications, including histone modification and chromatin…”
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Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis by Quenelle, Debra C., Birkmann, Alexander, Goldner, Thomas, Pfaff, Tamara, Zimmermann, Holger, Bonsmann, Susanne, Collins, Deborah J., Rice, Terri L., Prichard, Mark N.

“…Pritelivir, a helicase-primase inhibitor, has excellent in vitro and in vivo activity against human herpes simplex virus (HSV). Mice lethally infected with HSV…”
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Efficacy of CMX001 against Herpes Simplex Virus Infections in Mice and Correlations with Drug Distribution Studies by Quenelle, Debra C., Lampert, Bernhardt, Collins, Deborah J., Rice, Terri L., Painter, George R., Kern, Earl R.

“…CMX001, an orally active lipid conjugate of cidofovir, is 50 times more active in vitro against herpes simplex virus (HSV) replication than acyclovir or…”
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Synergistic Efficacy of the Combination of ST-246 with CMX001 against Orthopoxviruses by QUENELLE, Debra C, PRICHARD, Mark N, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, PAINTER, George R, ROBERTSON, Alice, KERN, Earl R

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CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections by Prichard, Mark N, Kern, Earl R, Hartline, Caroll B, Lanier, E. Randall, Quenelle, Debra C

“…Although acyclovir (ACV) has proven to be of value in the therapy of certain herpes simplex virus (HSV) infections, there is a need for more effective…”
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Efficacy of Delayed Treatment with ST-246 Given Orally against Systemic Orthopoxvirus Infections in Mice by QUENELLE, Debra C, BULLER, R. M. L, PARKER, Scott, KEITH, Kathy A, HRUBY, Dennis E, JORDAN, Robert, KERN, Earl R

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Preclinical Evaluation of a Genetically Engineered Herpes Simplex Virus Expressing Interleukin-12 by MARKERT, James M, CODY, James J, CARTNER, Samuel C, YANCEY GILLESPIE, G, WHITLEY, Richard J, PARKER, Jacqueline N, COLEMAN, Jennifer M, PRICE, Kathleen H, KERN, Earl R, QUENELLE, Debra C, LAKEMAN, Alfred D, SCHOEB, Trenton R, PALMER, Cheryl A

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In vitro and in vivo evaluation of isatin-β-thiosemicarbazone and marboran against vaccinia and cowpox virus infections by Quenelle, Debra C., Keith, Kathy A., Kern, Earl R.

“…It has been reported previously that some thiosemicarbazone compounds have prophylactic activity against smallpox disease and therapeutic activity against…”
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Oral Treatment of Cowpox and Vaccinia Virus Infections in Mice with Ether Lipid Esters of Cidofovir by Quenelle, Debra C, Collins, Deborah J, Wan, W Brad, Beadle, James R, Hostetler, Karl Y, Kern, Earl R

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Inhibition of Herpesvirus Replication by 5-Substituted 4′-Thiopyrimidine Nucleosides by PRICHARD, Mark N, QUENELLE, Debra C, SECRIST, John A, KERN, Earl R, HARTLINE, Caroll B, HARDEN, Emma A, JEFFERSON, Geraldine, FREDERICK, Samuel L, DAILY, Shannon L, WHITLEY, Richard J, TIWARI, Kamal N, MADDRY, Joseph A

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Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir by Li, Chengwei, Quenelle, Debra C., Prichard, Mark N., Drach, John C., Zemlicka, Jiri

“…Synthesis of 6-deoxycyclopropavir (10), a prodrug of cyclopropavir (1) and its in vitro and in vivo antiviral activity is described. 2-Amino-6-chloropurine…”
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Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus Infections by Kern, Earl R, Bidanset, Deborah J, Hartline, Caroll B, Yan, Zhaohua, Zemlicka, Jiri, Quenelle, Debra C

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Activity and Mechanism of Action of N-Methanocarbathymidine against Herpesvirus and Orthopoxvirus Infections by PRICHARD, Mark N, KEITH, Kathy A, QUENELLE, Debra C, KERN, Earl R

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Isolation and characterization of cidofovir resistant vaccinia viruses by Becker, Marie N, Obraztsova, Maria, Kern, Earl R, Quenelle, Debra C, Keith, Kathy A, Prichard, Mark N, Luo, Ming, Moyer, Richard W

“…The emergence of drug resistant viruses, together with the possibility of increased virulence, is an important concern in the development of new antiviral…”
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Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246 by Quenelle, Debra C, Kern, Earl R

“…Although a large number of compounds have been identified with antiviral activity against orthopoxviruses in tissue culture systems, it is highly preferred…”
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Effect of Oral Treatment with Hexadecyloxypropyl-[(S)-9-(3-Hydroxy-2- Phosphonylmethoxypropyl)Adenine] [(S)-HPMPA] or Octadecyloxyethyl-(S)-HPMPA on Cowpox or Vaccinia Virus Infections in Mice by QUENELLE, Debra C, COLLINS, Deborah J, HERROD, Bridgett P, KEITH, Kathy A, TRAHAN, Julissa, BEADLE, James R, HOSTETLER, Karl Y, KERN, Earl R

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Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir by KERN, Earl R, COLLINS, Deborah J, WAN, W. Brad, BEADLE, James R, HOSTETLER, Karl Y, QUENELLE, Debra C

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Activities of Certain 5-Substituted 4′-Thiopyrimidine Nucleosides against Orthopoxvirus Infections by KERN, Earl R, PRICHARD, Mark N, QUENELLE, Debra C, KEITH, Kathy A, TIWARI, Kamal N, MADDRY, Joseph A, SECRIST, John A

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Efficacy of Multiple- or Single-Dose Cidofovir against Vaccinia and Cowpox Virus Infections in Mice by QUENELLE, Debra C, COLLINS, Deborah J, KERN, Earl R

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