Search Results - "Quelle, D E"

RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis by Huang, J, Stewart, A, Maity, B, Hagen, J, Fagan, R L, Yang, J, Quelle, D E, Brenner, C, Fisher, R A

“…The RAS protooncogene has a central role in regulation of cell proliferation, and point mutations leading to oncogenic activation of Ras occur in a large…”
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D-type cyclin-dependent kinase activity in mammalian cells by MATSUSHIME, H, QUELLE, D. E, SHURTLEFF, S. A, SHIBUYA, M, SHERR, C. J, KATO, J.-Y

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NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma by Hao, M, Franqui-Machin, R, Xu, H, Shaughnessy, J, Barlogie, B, Roodman, D, Quelle, D E, Janz, S, Tomasson, M H, Sanderson, R D, Qiu, L, Frech, I, Tricot, G, Zhan, F

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Radiomic biomarkers informative of cancerous transformation in neurofibromatosis-1 plexiform tumors by Uthoff, J., De Stefano, F.A., Panzer, K., Darbro, B.W., Sato, T.S., Khanna, R., Quelle, D.E., Meyerholz, D.K., Weimer, J., Sieren, J.C.

“…This study explores whether objective, quantitative radiomic biomarkers derived from magnetic resonance (MR), positron emission tomography (PET), and computed…”
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The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways by MODESTOU, Modestos, PUIG-ANTICH, Valerie, KORGAONKAR, Chandrashekhar, EAPEN, Alex, QUELLE, Dawn E

“…The alternative reading frame (ARF) tumor suppressor mediates growth arrest or apoptosis through activation of the p53 tumor suppressor. A prevailing concept…”
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Localized cytosolic domains of the erythropoietin receptor regulate growth signaling and down-modulate responsiveness to granulocyte-macrophage colony-stimulating factor by QUELLE, D. E, WOJCHOWSKI, D. M

“…Erythrocyte development in mammals depends in part upon the interaction of the glycopeptide hormone erythropoietin (EPO) with cell surface receptors on…”
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Mutations in the WSAWSE and cytosolic domains of the erythropoietin receptor affect signal transduction and ligand binding and internalization by QUELLE, D. E, QUELLE, F. W, WOJCHOWSKI, D. M

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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts by Quelle, D E, Ashmun, R A, Shurtleff, S A, Kato, J Y, Bar-Sagi, D, Roussel, M F, Sherr, C J

“…Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell…”
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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest by Ouelle, Dawn E., Zindy, Frédérique, Ashmun, Richard A., Sherr, Charles J.

“…The INK4a ( MTS1, CDKN2) gene encodes an inhibitor (p16 INK4a) of the cyclin D-dependent kinases CDK4 and CDK6 that blocks them from phosphorylating the…”
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The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells by He, T C, Jiang, N, Zhuang, H, Quelle, D E, Wojchowski, D M

“…The development of erythroid progenitor cells depends upon exposure to the glycoprotein hormone, erythropoietin (EPO). Binding of EPO to its transmembrane…”
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ARF Function Does Not Require p53 Stabilization or Mdm2 Relocalization by Korgaonkar, Chandrashekhar, Zhao, Lili, Modestou, Modestos, Quelle, Dawn E.

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Interleukin 3, granulocyte-macrophage colony-stimulating factor, and transfected erythropoietin receptors mediate tyrosine phosphorylation of a common cytosolic protein (pp100) in FDC-ER cells by Quelle, F W, Quelle, D E, Wojchowski, D M

“…Receptors for the hematopoietic growth factors erythropoietin, interleukin 3 (IL-3), and granulocyte-macrophage colony-stimulating factor (GM-CSF) are members…”
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Dna damage-induced G(1) arrest in hematopoietic cells is overridden following phosphatidylinositol 3-kinase-dependent activation of cyclin-dependent kinase 2 by Eapen, A K, Henry, M K, Quelle, D E, Quelle, F W

“…Exposure of hematopoietic cells to DNA-damaging agents induces p53-independent cell cycle arrest at a G(1) checkpoint. Previously, we have shown that this…”
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D-type cyclins and their cyclin-dependent kinases: G1 phase integrators of the mitogenic response by Sherr, C J, Kato, J, Quelle, D E, Matsuoka, M, Roussel, M F

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C80-C IMAGING METHODOLOGY AND APPLICATION TO LUNG DISEASE: Development Of A Lung Cancer Pig Model: Non-Invasive Characterization With Computed Tomography by Hammond, E, Quelle, D E, Alaiwa, M H Abou, Stark, K, Saylor, M, Hogue, S, Rohret, F, Newell, J D, Sheehy, R M, Shaik Amjad, U S, Meyerholz, D K, Darbro, B W, Rogers, C S, Sieren, J C

“…Lung cancer is the leading cause of cancer-related deaths in the United States with a 5-year survival rate of 18% leaving room for improvement in non-invasive…”
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Expression of the p16INK4A tumor suppressor versus other INK4 family members during mouse development and aging by ZINDY, F, QUELLE, D. E, ROUSSEL, M. F, SHERR, C. J

“…Four INK4 proteins can prevent cell proliferation by specifically inhibiting cyclin D-dependent kinases. Both p18INK4c and p19INK4d were widely expressed…”
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Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors by LINARDOPOULOS, S, STREET, A. J, QUELLE, D. E, PARRY, D, PETERS, G, SHERR, C. J, BALMAIN, A

“…p16INK4a and p15INK4b are cell cycle regulators that specifically bind to and inhibit the cyclin D-dependent kinases, cdk4 and cdk6. Because these genes…”
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RABL6A Promotes Oxaliplatin Resistance in Tumor Cells and Is a New Marker of Survival for Resected Pancreatic Ductal Adenocarcinoma Patients by Muniz, Viviane P, Askeland, Ryan W, Zhang, Xuefeng, Reed, Sara M, Tompkins, Van S, Hagen, Jussara, McDowell, Bradley D, Button, Anna, Smith, Brian J, Weydert, Jamie A, Mezhir, James J, Quelle, Dawn E

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by early recurrence following pancreatectomy, rapid progression, and chemoresistance. Novel prognostic…”
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Nucleophosmin (B23) Targets ARF to Nucleoli and Inhibits Its Function by Korgaonkar, Chandrashekhar, Hagen, Jussara, Tompkins, Van, Frazier, April A., Allamargot, Chantal, Quelle, Frederick W., Quelle, Dawn E.

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 by Kamijo, Takehiko, Zindy, Frederique, Roussel, Martine F., Quelle, Dawn E., Downing, James R., Ashmun, Richard A., Grosveld, Gerard, Sherr, Charles J.

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