Biochemical and hematological evaluation in subjects with intellectual disability associated or not to Down syndrome

ABSTRACT Down syndrome (DS) is one of the most leading causes of intellectual disability. The aim of this study was to compare biochemical and hematological parameters, triglyceride/high-density lipoprotein cholesterol (HDL-C) and neutrophil/lymphocyte ratios in individuals with intellectual disabil...

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Published in:Jornal brasileiro de patologia e medicina laboratorial Vol. 54; no. 1; pp. 9 - 13
Main Authors: Mierlo, Andressa I. Van, Queje, Isabella Cristina, Simionatto, Mackelly, Brito, Priscilla S., Santos, Fabio André dos, Vellosa, José Carlos R., Borato, Danielle Cristyane K.
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Patologia Clínica; Sociedade Brasileira de Patologia; Sociedade Brasileira de Citopatologia 01-02-2018
Sociedade Brasileira de Patologia Clínica
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Summary:ABSTRACT Down syndrome (DS) is one of the most leading causes of intellectual disability. The aim of this study was to compare biochemical and hematological parameters, triglyceride/high-density lipoprotein cholesterol (HDL-C) and neutrophil/lymphocyte ratios in individuals with intellectual disabilities (ID) associated or not with DS. The main result is the lower HDL-C level in individuals with DS than in the ID group, suggesting a modification in the lipid profile whose origin would lie in genetic alterations. However, further researches are important to analyze if there is any link between trisomy 21 and the reduction of plasma HDL-C levels in individuals with DS.
ISSN:1676-2444
1678-4774
1678-4774
DOI:10.5935/1676-2444.20180005