Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients

We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius a...

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Bibliographic Details
Published in:	Applied physiology, nutrition, and metabolism Vol. 36; no. 5; p. 764
Main Authors:	Gualano, Bruno, Lugaresi, Rebeca, de Salles Painelli, Vitor, Painelli de Salles, Vitor, Queiroz, Andréia Cristina Carrenho, Artioli, Guilherme, Roschel, Hamilton, Otaduy, Maria Concepción, Leite, Cláudia da Costa, Lancha, Jr, Antonio Herbert
Format:	Journal Article
Language:	English
Published:	Canada 01-10-2011
Subjects:	Body Mass Index Creatine - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - therapy Dietary Supplements Double-Blind Method Exercise Female Humans Leg Magnetic Resonance Spectroscopy Male Middle Aged Muscle Fibers, Fast-Twitch - metabolism Muscle Fibers, Slow-Twitch - metabolism Muscle, Skeletal - metabolism
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Summary:	We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g·day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients.
ISSN:	1715-5312
DOI:	10.1139/h11-083