Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats

Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats

The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously int...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 718; no. 1-3; pp. 213 - 218
Main Authors: Queenthy, S.Sharmila, John, Babu
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 15-10-2013
Subjects:
Animals
Biomarkers - blood
blood lipids
blood serum
body weight
cardioprotective effect
Diosmin
Diosmin - pharmacology
Electrocardiogram
electrocardiography
enzymes
free radical scavengers
Heart Ventricles - drug effects
Heart Ventricles - pathology
Hypolipidemic Agents - pharmacology
in vitro studies
Isoproterenol
Isoproterenol - adverse effects
lipid metabolism
Lipid Metabolism - drug effects
lipid peroxidation
Lipids
Lipo proteins
liver
Male
Myocardial infarction
Myocardial Infarction - chemically induced
Myocardial Infarction - metabolism
Myocardial Infarction - pathology
oral administration
Rats
Rats, Wistar
Myocardial infarction
Lipo proteins
Lipids
Isoproterenol
Electrocardiogram
Diosmin
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Summary:The aim of the present study was to evaluate the protective effects of diosmin on experimentally induced myocardial infarcted rats. Diosmin (5 and 10mg/kg body weight) was administered orally as pretreatment daily for a period of 10 days. Then isoproterenol (100mg/kg) was injected subcutaneously into rats at an interval of 24h for 2 days (on 11th and 12th day). Isoproterenol-induced myocardial infarcted rats showed significant changes in electrocardiogram and an increase in the levels of cardiac markers, compared with normal rats. Additionally, increased plasma lipid peroxidation products and altered lipid metabolism in the plasma were observed in the isoproterenol-induced myocardial infarcted rats. Pretreatment with diosmin (5 and 10mg/kg body weight) minimized the electrocardiographic changes, decreased the levels of serum cardiac marker enzymes reduced plasma lipid peroxidation and minimized the alterations in the lipid metabolism of isoproterenol-induced myocardial infarcted rats. Also, diosmin inhibited the enhanced activity of liver HMG CoA reductase. The in vitro study revealed the free radical scavenging activity of diosmin. The free radical scavenging and anti-hyperlipidaemic effects are the reasons for the cardioprotective effects of diosmin.
Bibliography:http://dx.doi.org/10.1016/j.ejphar.2013.08.031
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2013.08.031