Search Results - "Queen, Nicholas J"

Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now? by Queen, Nicholas J, Hassan, 2nd, Quais N, Cao, Lei

“…Environmental enrichment (EE) is an experimental paradigm that is used to explore how a complex, stimulating environment can impact overall health. In…”
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Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop by Huang, Wei, Queen, Nicholas J., McMurphy, Travis B., Ali, Seemaab, Cao, Lei

“…Despite the large body of work describing the tumor suppressor functions of Phosphatase and tensin homologue deleted on chromosome ten (PTEN), its roles in…”
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Protocol to minimize the confounding effect of cold stress on socially isolated mice using thermoneutral housing by Appana, Bhavya, Queen, Nicholas J., Cao, Lei

“…Social isolation, a risk factor for mortality and various disease states, in mice remains poorly understood, due in part to under-consideration of housing…”
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AAV-BDNF gene therapy ameliorates a hypothalamic neuroinflammatory signature in the Magel2-null model of Prader-Willi syndrome by Queen, Nicholas J., Huang, Wei, Zou, Xunchang, Mo, Xiaokui, Cao, Lei

“…Individuals with Prader-Willi syndrome (PWS) exhibit several metabolic and behavioral abnormalities associated with excessive food-seeking activity. PWS is…”
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Visceral adipose tissue-directed FGF21 gene therapy improves metabolic and immune health in BTBR mice by Queen, Nicholas J., Bates, Rhiannon, Huang, Wei, Xiao, Run, Appana, Bhavya, Cao, Lei

“…Fibroblast growth factor 21 (FGF21) is a peptide hormone that serves as a potent effector of energy homeostasis. Increasingly, FGF21 is viewed as a promising…”
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Hypothalamic AAV-BDNF gene therapy improves metabolic function and behavior in the Magel2-null mouse model of Prader-Willi syndrome by Queen, Nicholas J., Zou, Xunchang, Anderson, Jacqueline M., Huang, Wei, Appana, Bhavya, Komatineni, Suraj, Wevrick, Rachel, Cao, Lei

“…Individuals with Prader-Willi syndrome (PWS) display developmental delays, cognitive impairment, excessive hunger, obesity, and various behavioral…”
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Targeting Visceral Fat by Intraperitoneal Delivery of Novel AAV Serotype Vector Restricting Off-Target Transduction in Liver by Huang, Wei, Liu, Xianglan, Queen, Nicholas J, Cao, Lei

“…It is challenging to genetically manipulate fat in adults. We demonstrate that intraperitoneal (i.p.) injection of an engineered adeno-associated virus (AAV)…”
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Social isolation exacerbates diet-induced obesity and peripheral inflammation in young male mice under thermoneutrality by Queen, Nicholas J., Huang, Wei, Komatineni, Suraj, Mansour, Anthony G., Xiao, Run, Chrislip, Logan A., Cao, Lei

“…Social isolation (SI) is associated with an increased risk of mortality and various chronic diseases—including obesity—in humans. Murine studies probing SI…”
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Regulation of aging and cancer by enhanced environmental activation of a hypothalamic-sympathoneural-adipocyte axis by Hassan II, Quais N., Queen, Nicholas J., Cao, Lei

“…Social and environmental factors impact cancer and energy balance profoundly. Years ago, our lab established the existence of a novel brain-fat interaction we…”
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Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector by Siu, Jason J, Queen, Nicholas J, Liu, Xianglan, Huang, Wei, McMurphy, Travis, Cao, Lei

“…Mutations in the melanocortin-4-receptor ( ) comprise the most common monogenic form of severe early-onset obesity, and conventional treatments are either…”
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Adipose PTEN acts as a downstream mediator of a brain-fat axis in environmental enrichment by Huang, Wei, Queen, Nicholas J., McMurphy, Travis B., Ali, Seemaab, Wilkins, Ryan K., Appana, Bhavya, Cao, Lei

“…Environmental enrichment (EE) is a physiological model to investigate brain-fat interactions. We previously discovered that EE activates the…”
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rAAV-Mediated Gene Delivery to Adipose Tissue by Huang, Wei, Queen, Nicholas J, Cao, Lei

“…Recombinant adeno-associated virus (rAAV) vectors are attractive vehicles for gene therapy. Yet, it is challenging to genetically manipulate adipose tissue in…”
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Environmental enrichment improves metabolic and behavioral health in the BTBR mouse model of autism by Queen, Nicholas J., Boardman, Amber A., Patel, Ripal S., Siu, Jason J., Mo, Xiaokui, Cao, Lei

“…•Environmental enrichment ameliorated metabolic/social deficits in an autism model.•Male mice respond to an autism/metabolic treatment more readily than…”
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Hypothalamic gene transfer of BDNF promotes healthy aging by Cao, Lei, Ali, Seemaab, Queen, Nicholas J

“…The aging process and age-related diseases all involve metabolic decline and impaired ability to cope with adversity. Environmental enrichment (EE)-a housing…”
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Hypothalamic gene transfer of BDNF promotes healthy aging in mice by McMurphy, Travis, Huang, Wei, Liu, Xianglan, Siu, Jason J., Queen, Nicholas J., Xiao, Run, Cao, Lei

“…The aging process and age‐related diseases all involve perturbed energy adaption and impaired ability to cope with adversity. Brain‐derived neurotrophic factor…”
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Environmental Enrichment Mitigates Age-Related Metabolic Decline and Lewis Lung Carcinoma Growth in Aged Female Mice by Queen, Nicholas J, Deng, Hong, Huang, Wei, Mo, Xiaokui, Wilkins, Ryan K, Zhu, Tao, Wu, Xiaoyu, Cao, Lei

“…Aging is a complex physiological process that leads to the progressive decline of metabolic and immune function, among other biological mechanisms. As global…”
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Enriched environment inhibits breast cancer progression in obese models with intact leptin signaling by Foglesong, Grant D, Queen, Nicholas J, Huang, Wei, Widstrom, Kyle J, Cao, Lei

“…Obesity is becoming a global epidemic and is a risk factor for breast cancer. Environmental enrichment (EE), a model recapitulating an active lifestyle, leads…”
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Adipocytes: A Novel Target for IL-15/IL-15Rα Cancer Gene Therapy by Xiao, Run, Mansour, Anthony G., Huang, Wei, Chrislip, Logan A., Wilkins, Ryan K., Queen, Nicholas J., Youssef, Youssef, Mao, Hsiaoyin C., Caligiuri, Michael A., Cao, Lei

“…IL-15 is a proinflammatory cytokine that plays an essential role in the development and activation of natural killer (NK) cells. Adipose tissue acts as an…”
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Long-term environmental enrichment affects microglial morphology in middle age mice by Ali, Seemaab, Liu, Xianglan, Queen, Nicholas J, Patel, Ripal S, Wilkins, Ryan K, Mo, Xiaokui, Cao, Lei

“…Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a…”
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Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice by Xiao, Run, Bergin, Stephen M., Huang, Wei, Mansour, Anthony G, Liu, Xianglan, Judd, Ryan T, Widstrom, Kyle J., Queen, Nicholas J., Wilkins, Ryan K., Siu, Jason J., Ali, Seemaab, Caligiuri, Michael A., Cao, Lei

“…•Environmental enrichment (EE) modulates thymocyte maturation and selection in mice.•Hypothalamic BDNF mediates the EE-induced thymic phenotypes.•Adrenalectomy…”
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