Search Results - "Que, Nanette L. S"

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding by Que, Nanette L. S, Crowley, Vincent M, Duerfeldt, Adam S, Zhao, Jinbo, Kent, Caitlin N, Blagg, Brian S. J, Gewirth, Daniel T

“…Grp94 and Hsp90, the ER and cytoplasmic hsp90 paralogs, share a conserved ATP-binding pocket that has been targeted for therapeutics. Paralog-selective…”
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Exploring the Functional Complementation between Grp94 and Hsp90 by Maharaj, Kevin A, Que, Nanette L S, Hong, Feng, Huck, John D, Gill, Sabrina K, Wu, Shuang, Li, Zihai, Gewirth, Daniel T

“…Grp94 and Hsp90 are the ER and cytoplasmic paralog members, respectively, of the hsp90 family of molecular chaperones. The structural and biochemical…”
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Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94-Selective Ligand Binding by Que, Nanette L S, Seidler, Paul M, Aw, Wen J, Chiosis, Gabriela, Gewirth, Daniel T

“…Grp94 is the endoplasmic reticulum paralog of the hsp90 family of chaperones, which have been targeted for therapeutic intervention via their highly conserved…”
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NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90 by Huck, John D., Que, Nanette L.S., Immormino, Robert M., Shrestha, Liza, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.

“…The hsp90 chaperones govern the function of essential client proteins critical for normal cell function as well as cancer initiation and progression. Hsp90…”
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Structures of Hsp90α and Hsp90β bound to a purine‐scaffold inhibitor reveal an exploitable residue for drug selectivity by Huck, John D., Que, Nanette L. S., Sharma, Sahil, Taldone, Tony, Chiosis, Gabriela, Gewirth, Daniel T.

“…ABSTRACT Hsp90α and Hsp90β are implicated in a number of cancers and neurodegenerative disorders but the lack of selective pharmacological probes confounds…”
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Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone by Yan, Pengrong, Patel, Hardik J., Sharma, Sahil, Corben, Adriana, Wang, Tai, Panchal, Palak, Yang, Chenghua, Sun, Weilin, Araujo, Thais L., Rodina, Anna, Joshi, Suhasini, Robzyk, Kenneth, Gandu, Srinivasa, White, Julie R., de Stanchina, Elisa, Modi, Shanu, Janjigian, Yelena Y., Hill, Elizabeth G., Liu, Bei, Erdjument-Bromage, Hediye, Neubert, Thomas A., Que, Nanette L.S., Li, Zihai, Gewirth, Daniel T., Taldone, Tony, Chiosis, Gabriela

“…Stresses associated with disease may pathologically remodel the proteome by both increasing interaction strength and altering interaction partners, resulting…”
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An Outer Membrane Enzyme That Generates the 2-Amino-2- deoxy-gluconate Moiety of Rhizobium leguminosarum Lipid A by Que-Gewirth, Nanette L S, Lin, Shanhua, Cotter, Robert J, Raetz, Christian R H

“…The structures of Rhizobium leguminosarum and Rhizobium etli lipid A are distinct from those found in other Gram-negative bacteria. Whereas the more typical…”
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A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2 by Que-Gewirth, Nanette L S, Ribeiro, Anthony A, Kalb, Suzanne R, Cotter, Robert J, Bulach, Dieter M, Adler, Ben, Girons, Isabelle Saint, Werts, Catherine, Raetz, Christian R H

“…Leptospira interrogans differs from other spirochetes in that it contains homologs of all the Escherichia coli lpx genes required for the biosynthesis of the…”
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Biosynthesis of Mycarose:  Isolation and Characterization of Enzymes Involved in the C-2 Deoxygenation by Chen, Huawei, Agnihotri, Gautam, Guo, Zhihong, Que, Nanette L. S, Chen, Xuemei H, Liu, Hung-wen

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Mechanistic Studies of Desosamine Biosynthesis:  C-4 Deoxygenation Precedes C-3 Transamination by Zhao, Lishan, Que, Nanette L. S, Xue, Yongquan, Sherman, David H, Liu, Hung-wen

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Expression, Purification, and Characterization of TylB, an Aminotransferase Involved in the Biosynthesis of Mycaminose by Chen, Huawei, Yeung, Siu-Man, Que, Nanette L. S, Müller, Thomas, Schmidt, Richard R, Liu, Hung-wen

“…Amino sugars are ubiquitously found in nature as constituents of glycoproteins, glycolipids, and a great variety of secondary metabolites. They have been shown…”
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Origin of the 2-amino-2-deoxy-gluconate unit in Rhizobium leguminosarum lipid A. Expression cloning of the outer membrane oxidase LpxQ by Que-Gewirth, Nanette L S, Karbarz, Mark J, Kalb, Suzanne R, Cotter, Robert J, Raetz, Christian R H

“…An unusual feature of the lipid A from the plant endosymbionts Rhizobium etli and Rhizobium leguminosarum is the presence of a proximal sugar unit consisting…”
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Mechanistic Studies of the Biosynthesis of Paratose:  Purification and Characterization of CDP-paratose Synthase by Hallis, Tina M, Lei, Yenyoung, Que, Nanette L. S, Liu, Hung-wen

“…The 3,6-dideoxyhexoses can be found in the cell wall lipopolysaccharide of Gram-negative bacteria, where they have been shown to be the dominant antigenic…”
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Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion by Que, N L, Lin, S, Cotter, R J, Raetz, C R

“…Lipid A of Rhizobium etli CE3 differs dramatically from that of other Gram-negative bacteria. Key features include the presence of an unusual C28 acyl chain, a…”
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A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O-linked beta-hydroxymyristoyl moiety of lipid a precursors by Basu, S.S. (Duke University Medical Center, Durham, NC.), White, K.A, Que, N.L.S, Raetz, C.R.H

“…Lipid A from the nitrogen-fixing bacterium Rhizobium leguminosarum displays many structural differences compared with lipid A of Escherichia coli. R…”
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Two-dimensional NMR Spectroscopy and Structures of Six Lipid A Species from Rhizobium etli CE3 DETECTION OF AN ACYLOXYACYL RESIDUE IN EACH COMPONENT AND ORIGIN OF THE AMINOGLUCONATE MOIETYS by Que, Nanette L. S., Ribeiro, Anthony A., Raetz, Christian R. H.

“…The chemical structures of six lipid A species (A, B, C, D-1, D-2, and E) purified from Rhizobium etli CE3 were investigated by one- and two-dimensional NMR…”
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A Methylated Phosphate Group and Four Amide-linked Acyl Chains in Leptospira interrogans Lipid A by Que-Gewirth, Nanette L.S., Ribeiro, Anthony A., Kalb, Suzanne R., Cotter, Robert J., Bulach, Dieter M., Adler, Ben, Girons, Isabelle Saint, Werts, Catherine, Raetz, Christian R.H.

“…Leptospira interrogans differs from other spirochetes in that it contains homologs of all the Escherichia coli lpx genes required for the biosynthesis of the…”
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Origin of the 2-Amino-2-deoxy-gluconate Unit inRhizobium leguminosarum Lipid A by Que-Gewirth, Nanette L.S., Karbarz, Mark J., Kalb, Suzanne R., Cotter, Robert J., Raetz, Christian R.H.

“…An unusual feature of the lipid A from the plant endosymbionts Rhizobium etli and Rhizobium leguminosarum is the presence of a proximal sugar unit consisting…”
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Two-dimensional NMR Spectroscopy and Structures of Six Lipid A Species from Rhizobium etli CE3 by Que, Nanette L.S., Ribeiro, Anthony A., Raetz, Christian R.H.

“…The chemical structures of six lipid A species (A, B, C, D-1, D-2, and E) purified from Rhizobium etli CE3 were investigated by one- and two-dimensional NMR…”
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A Deacylase in Rhizobium leguminosarum Membranes That Cleaves the 3-O-Linked β-Hydroxymyristoyl Moiety of Lipid A Precursors by Shib Sankar Basu, Kimberly A. White, Nanette L. S. Que, Christian R. H. Raetz

“…Lipid A from the nitrogen-fixing bacterium Rhizobium leguminosarum displays many structural differences compared with lipid A of Escherichia coli. R…”
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