Search Results - "Quayle, Steve"

793 Targeting engineered interleukin-2 (IL-2) to antigen specific T cells via novel biologic platforms by Moniz, Raymond, Vakkasoglu, Ahmet, Merazga, Zohra, Daigneault, Tina, Quayle, Steve, Girgis, Natasha, Seidel, Ronald, Ross, John, Low, Simon, Suri, Anish

“…BackgroundA key challenge with IL-2 immunotherapy for cancers is lack of selectivity for anti-tumor immune cells and safety liabilities related to…”
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750 A phase 1 trial of CUE-102, a novel WT1-pHLA-IL2-Fc fusion protein in HLA-A0201 positive patients with WT1-positive recurrent/metastatic cancers by Eva Selfridge, J, Uboha, Nataliya, Saenger, Yvonne, Chaves, Jorge, Zheng, Lei, Powderly, John, Kim, Dae Won, Alese, Olatunji, Fu, Siqing, Gong, Jun, Gabrail, Nashat, Zhaohui, Jin, Bekaii-Saab, Tanios, Alistar, Angela, Agensky, Laura, Goel, Apollina, Margossian, Steven, Quayle, Steve, Levisetti, Matteo

“…BackgroundImmuno-STATs are modular fusion proteins designed for the selective activation of tumor antigen specific CD8+ T cells. CUE-102, the second…”
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674 A phase 1 dose-escalation and expansion study of CUE-101, given as monotherapy in 3L and in combination with pembrolizumab in 1L recurrent/metastatic HPV16+ head and neck cancer patients by Chung, Christine H, Adkins, Douglas, Dimitrios Colevas, A, Rodriguez, Cristina, Park, Jong Chul, Gibson, Michael K, Sukari, Ammar, Burtness, Barbara, Johnson, Faye, Julian, Ricklie, Saba, Nabil F, Worden, Francis, Dunn, Lara A, Seiwert, Tanguy Y, Jotte, Robert M, Haddad, Rami, Gabrail, Nashat, Bauman, Julie E, Chaney, Marya, Agensky, Laura, Goel, Apollina, Quayle, Steve, Margossian, Steven, Levisetti, Matteo, Pai, Sara

“…BackgroundImmuno-STATs are modular T cell engagers engineered to selectively activate tumor-antigen specific CD8+ T cells via targeted delivery of cytokines…”
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720 CUE-102 selectively activates and expands WT1-specific T cells for the treatment of patients with WT1+ malignancies by Zhang, Christie, Girgis, Natasha, Merazga, Zohra, Hatfield, Steven, Histed, Alex, Zhao, Fan, Moniz, Raymond, Yeung, Kristin, Diaz, Fulvio, Brown, Jason, Haydock, Mark, Witt, Luke, Bautista, Wynona, Ross, John, Cemerski, Saso, Suri, Anish, Pienta, Kenneth, Levisetti, Matteo, Quayle, Steve

“…BackgroundWilms' Tumor 1 (WT1) was ranked as the highest priority antigen for therapeutic targeting in an effort by the National Cancer Institute. Development…”
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438 A phase 1 trial of CUE-101, a novel HPV16 E7-pHLA-IL2-Fc fusion protein, alone and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck cancer by Chung, Christine, Dimitrios Colevas, A, Gibson, Michael, Adkins, Douglas, Sukari, Ammar, Wirth, Lori, Burtness, Barbara, Bauman, Julie, Rodriguez, Cristina, Worden, Francis, Saba, Nabil, Glisson, Bonnie, Dunn, Lara, Seiwert, Tanguy, Agensky, Laura, Levisetti, Matteo, Lynam, Reena, Margossian, Steven, Moniz, Raymond, Quayle, Steve, Pienta, Kenneth, Pai, Sara

“…BackgroundImmuno-STATsTM are novel, modular fusion proteins designed to selectively activate tumor-antigen-specific CD8+ T cells. CUE-101 is comprised of a…”
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Abstract 6699: CUE-102 Immuno-STATs for selective targeting and expansion of WT1-specific T cells for the treatment of HLA-A02+and/or HLA-A24+patients with WT1+ malignancies by Thapa, Dharma, Histed, Alex, Soriano, Jonathan, Witt, Luke, Merazga, Zohra, Girgis, Natasha, Moreta, Miguel, Diaz, Fulvio, Zhao, Fan, Kemp, Melissa, Ruthardt, Paige, Suri, Anish, Quayle, Steve, Ross, John, Cemerski, Saso

“…WT1 has been ranked first amongst 75 tumor associated antigens in an effort by the National Cancer Institute to prioritize cancer antigens for therapeutic…”
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636 A phase 1, open-label, dose escalation and expansion study of CUE-102 monotherapy in HLA-A0201 positive patients with WT1-positive recurrent/metastatic cancers by Margossian, Steven, Powderly, John, Nashat Gabrail, Saenger, Yvonne, Selfridge, J Eva, Uboha, Nataliya, Gong, Jun, Brian Van Tine, Alese, Olatunji, Kim, Dae Won, Ma, Wen, Bekaii-Saab, Tanios, Jones, Jeremy, Alistar, Angela, Agensky, Laura, Goel, Apollina, Lynam, Reena, Moniz, Raymond, Quayle, Steve, Rajan, Cynthia, Pienta, Kenneth, Levisetti, Matteo

“…BackgroundImmuno-STATsTM are modular fusion proteins designed for the selective activation of tumor-antigen specific CD8+ T cells. CUE-102, the second…”
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