Search Results - "Quax, Paul"

Vein graft failure: from pathophysiology to clinical outcomes by de Vries, Margreet R., Simons, Karin H., Jukema, J. Wouter, Braun, Jerry, Quax, Paul H. A.

“…Key Points Thrombosis, constrictive remodelling, intimal hyperplasia, and unstable atherosclerotic lesions are the critical mechanisms contributing to vein…”
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T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword by Simons, Karin H., de Jong, Alwin, Jukema, J. Wouter, de Vries, Margreet R., Arens, Ramon, Quax, Paul H. A.

“…The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune cells, including T cells, are influenced by inflammatory signals and…”
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Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis by Parma, Laura, Baganha, Fabiana, Quax, Paul H.A., de Vries, Margreet R.

“…Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque, represent the major cause of morbidity and mortality in patients. Growing…”
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Plaque angiogenesis and its relation to inflammation and atherosclerotic plaque destabilization by de Vries, Margreet R., Quax, Paul H.A.

“…The review discusses the recent literature on plaque angiogenesis and its relation to inflammation and plaque destabilization. Furthermore, it discusses how…”
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The Multifaceted Functions of CXCL10 in Cardiovascular Disease by van den Borne, Pleunie, Quax, Paul H. A., Hoefer, Imo E., Pasterkamp, Gerard

“…C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for…”
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Variations in Surgical Procedures for Inducing Hind Limb Ischemia in Mice and the Impact of These Variations on Neovascularization Assessment by Aref, Zeen, de Vries, Margreet R, Quax, Paul H A

“…Mouse hind limb ischemia is the most common used preclinical model for peripheral arterial disease and critical limb ischemia. This model is used to…”
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The Intriguing World of Vascular Remodeling, Angiogenesis, and Arteriogenesis by Quax, Paul H A, Deindl, Elisabeth

“…Vascular remodeling is a very general feature related to angiogenesis and arteriogenesis, which are involved in neovascularization processes [...]…”
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Inhibition of 14q32 MicroRNAs miR-329, miR-487b, miR-494, and miR-495 Increases Neovascularization and Blood Flow Recovery After Ischemia by Welten, Sabine M.J, Bastiaansen, Antonius J.N.M, de Jong, Rob C.M, de Vries, Margreet R, Peters, Erna A.B, Boonstra, Martin C, Sheikh, Søren P, Monica, Nicola La, Kandimalla, Ekambar R, Quax, Paul H.A, Nossent, A Yaël

“…RATIONALE:Effective neovascularization is crucial for recovery after cardiovascular events. OBJECTIVE:Because microRNAs regulate expression of up to several…”
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Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization by van der Kwast, Reginald V.C.T, van Ingen, Eva, Parma, Laura, Peters, Hendrika A.B, Quax, Paul H.A, Nossent, A Yaël

“…RATIONALE:Adenosine-to-inosine editing of microRNAs has the potential to cause a shift in target site selection. 2′-O-ribose-methylation of adenosine residues,…”
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MicroRNA-411 and Its 5′-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia by van der Kwast, Reginald V.C.T., Woudenberg, Tamar, Quax, Paul H.A., Nossent, A. Yaël

“…MicroRNAs are posttranscriptional regulators of gene expression. As microRNAs can target many genes simultaneously, microRNAs can regulate complex…”
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In Vivo Matrigel Plug Assay as a Potent Method to Investigate Specific Individual Contribution of Angiogenesis to Blood Flow Recovery in Mice by Aref, Zeen, Quax, Paul H. A.

“…Neovascularization restores blood flow recovery after ischemia in peripheral arterial disease. The main two components of neovascularization are angiogenesis…”
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Arteriogenesis and Therapeutic Angiogenesis-An Update by Deindl, Elisabeth, Quax, Paul H A

“…Vascular occlusive diseases such myocardial infarction, peripheral artery disease of the lower extremities, or stroke still represent a substantial health…”
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Pericellular Proteases in Angiogenesis and Vasculogenesis by van Hinsbergh, Victor W.M, Engelse, Marten A, Quax, Paul H.A

“…Pericellular proteases play an important role in angiogenesis and vasculogenesis. They comprise (membrane-type) matrix metalloproteinases [(MT-)MMPs], serine…”
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Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo by Kooreman, Nigel G., Kim, Youngkyun, de Almeida, Patricia E., Termglinchan, Vittavat, Diecke, Sebastian, Shao, Ning-Yi, Wei, Tzu-Tang, Yi, Hyoju, Dey, Devaveena, Nelakanti, Raman, Brouwer, Thomas P., Paik, David T., Sagiv-Barfi, Idit, Han, Arnold, Quax, Paul H.A., Hamming, Jaap F., Levy, Ronald, Davis, Mark M., Wu, Joseph C.

“…Cancer cells and embryonic tissues share a number of cellular and molecular properties, suggesting that induced pluripotent stem cells (iPSCs) may be harnessed…”
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Hypercholesterolemia affects cardiac function, infarct size and inflammation in APOE3-Leiden mice following myocardial ischemia-reperfusion injury by Pluijmert, Niek J, den Haan, Melina C, van Zuylen, Vanessa L, Steendijk, Paul, de Boer, Hetty C, van Zonneveld, Anton J, Fibbe, Willem E, Schalij, Martin J, Quax, Paul H A, Atsma, Douwe E

“…Hypercholesterolemia is a major risk factor for ischemic heart disease including acute myocardial infarction. However, long-term effects of…”
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The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development by de Jong, Rob C M, Ewing, Mark M, de Vries, Margreet R, Karper, Jacco C, Bastiaansen, Antonius J N M, Peters, Hendrika A B, Baghana, Fabiana, van den Elsen, Peter J, Gongora, Céline, Jukema, J Wouter, Quax, Paul H A

“…Genetic P300/CBP-associated factor (PCAF) variation affects restenosis-risk in patients. PCAF has lysine acetyltransferase activity and promotes nuclear factor…”
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Epigenetics in atherosclerosis and inflammation by Wierda, Rutger J., Geutskens, Sacha B., Jukema, J. Wouter, Quax, Paul H.A., van den Elsen, Peter J.

“…•  Introduction •  Epigenetics explained ‐  Epigenetic alterations are reversible •  Atherosclerosis •  Epigenetics and association with atherosclerosis • …”
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Neovascularization Capacity of Mesenchymal Stromal Cells From Critical Limb Ischemia Patients Is Equivalent to Healthy Controls by Gremmels, Hendrik, Teraa, Martin, Quax, Paul HA, den Ouden, Krista, Fledderus, Joost O, Verhaar, Marianne C

“…Critical limb ischemia (CLI) is often poorly treatable by conventional management and alternatives such as autologous cell therapy are increasingly…”
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PFKFB3 gene deletion in endothelial cells inhibits intraplaque angiogenesis and lesion formation in a murine model of venous bypass grafting by Perrotta, Paola, de Vries, Margreet R., Peeters, Bart, Guns, Pieter-Jan, De Meyer, Guido R. Y., Quax, Paul H. A., Martinet, Wim

“…Vein grafting is a frequently used surgical intervention for cardiac revascularization. However, vein grafts display regions with intraplaque (IP)…”
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Systemic Upregulation of IL-10 (Interleukin-10) Using a Nonimmunogenic Vector Reduces Growth and Rate of Dissecting Abdominal Aortic Aneurysm by Adam, Matti, Kooreman, Nigel Geoffrey, Jagger, Ann, Wagenhäuser, Markus U, Mehrkens, Dennis, Wang, Yongming, Kayama, Yosuke, Toyama, Kensuke, Raaz, Uwe, Schellinger, Isabel N, Maegdefessel, Lars, Spin, Joshua M, Hamming, Jaap F, Quax, Paul H.A, Baldus, Stephan, Wu, Joseph C, Tsao, Philip S

“…OBJECTIVE—Recruitment of immunologic competent cells to the vessel wall is a crucial step in formation of abdominal aortic aneurysms (AAA). Innate immunity…”
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