Search Results - "Quax, P"

The multifactorial nature of microRNAs in vascular remodelling by Welten, S M J, Goossens, E A C, Quax, P H A, Nossent, A Y

“…Vascular remodelling is a multifactorial process that involves both adaptive and maladaptive changes of the vessel wall through, among others, cell…”
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Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease by Brinks, J., van Dijk, E.H.C., Klaassen, I., Schlingemann, R.O., Kielbasa, S.M., Emri, E., Quax, P.H.A., Bergen, A.A., Meijer, O.C., Boon, C.J.F.

“…The choroid is a key player in maintaining ocular homeostasis and plays a role in a variety of chorioretinal diseases, many of which are poorly understood…”
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Metabolic profile in endothelial cells of chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension by Smolders, V. F. E. D., Rodríguez, C., Blanco, I., Szulcek, R., Timens, Wim, Piccari, L., Roger, Y., Hu, X., Morén, Constanza, Bonjoch, C., Sebastián, L., Castellà, M., Osorio, J., Peinado, V. I., Bogaard, Harm Jan, Quax, P. H. A., Cascante, M., Barberà, J. A., Tura-Ceide, O.

“…Chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH) are two forms of pulmonary hypertension (PH) characterized by…”
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T-cell co-stimulation by CD28–CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development by Ewing, M.M, Karper, J.C, Abdul, S, de Jong, R.C.M, Peters, H.A.B, de Vries, M.R, Redeker, A, Kuiper, J, Toes, R.E.M, Arens, R, Jukema, J.W, Quax, P.H.A

“…Abstract Objective T-cells are central to the immune response responsible for native atherosclerosis. The objective of this study is to investigate T-cell…”
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Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels by de Vries, M. R., Parma, L., Peters, H. A. B., Schepers, A., Hamming, J. F., Jukema, J. W., Goumans, M. J. T. H., Guo, L., Finn, A. V., Virmani, R., Ozaki, C. K., Quax, P. H. A.

“…Background Plaque angiogenesis is associated with atherosclerotic lesion growth, plaque instability and negative clinical outcome. Plaque angiogenesis is a…”
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Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer by Baart, V. M., Houvast, R. D., de Geus-Oei, L. F., Quax, P. H. A., Kuppen, P. J. K., Vahrmeijer, A. L., Sier, C. F. M.

“…The urokinase plasminogen activator receptor (uPAR) plays a multifaceted role in almost any process where migration of cells and tissue-remodeling is involved…”
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Natural Killer Cells and CD4+ T-Cells Modulate Collateral Artery Development by van Weel, V, Toes, R E.M, Seghers, L, Deckers, M M.L, de Vries, M R, Eilers, P H, Sipkens, J, Schepers, A, Eefting, D, van Hinsbergh, V W.M, van Bockel, J H, Quax, P H.A

“…OBJECTIVE—The immune system is thought to play a crucial role in regulating collateral circulation (arteriogenesis), a vital compensatory mechanism in patients…”
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Treatment with intramuscular vascular endothelial growth factor gene compared with placebo for patients with diabetes mellitus and critical limb ischemia: a double-blind randomized trial by Kusumanto, Y H, van Weel, V, Mulder, N H, Smit, A J, van den Dungen, J J A M, Hooymans, J M M, Sluiter, W J, Tio, R A, Quax, P H A, Gans, R O B, Dullaart, R P F, Hospers, G A P

“…Despite advances in revascularization techniques, limb salvage and relief of pain cannot be achieved in many diabetic patients with diffuse peripheral vascular…”
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Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner by Amersfoort, J., Schaftenaar, F.H., Douna, H., van Santbrink, P.J., Kröner, M.J., van Puijvelde, G.H.M., Quax, P.H.A., Kuiper, J., Bot, I.

“…Lipocalin-2 (Lcn2) is a glycoprotein which can be secreted by immune cells. Several studies in humans have suggested Lcn2 can be used as a biomarker for the…”
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Anti–MCP-1 Gene Therapy Inhibits Vascular Smooth Muscle Cells Proliferation and Attenuates Vein Graft Thickening Both In Vitro and In Vivo by Schepers, A, Eefting, D, Bonta, P I, Grimbergen, J M, de Vries, M R, van Weel, V, de Vries, C J, Egashira, K, van Bockel, J H, Quax, P H.A

“…OBJECTIVE—Because late vein graft failure is caused by intimal hyperplasia (IH) and accelerated atherosclerosis, and these processes are thought to be…”
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Identification of IgG1 isotype phosphorylcholine antibodies for the treatment of inflammatory cardiovascular diseases by Vries, M. R., Ewing, M. M., Jong, R. C. M., MacArthur, M. R., Karper, J. C., Peters, E. A. B., Nordzell, M., Karabina, S. A. P., Sexton, D., Dahlbom, I., Bergman, A., Mitchell, J. R., Frostegård, J., Kuiper, J., Ninio, E., Jukema, J. W., Pettersson, K., Quax, P. H. A.

“…Background Phosphorylcholine (PC) is an important pro‐inflammatory damage‐associated molecular pattern. Previous data have shown that natural IgM anti‐PC…”
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A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons by Simons, K. H., Peters, H. A. B., Jukema, J. W., Vries, M. R., Quax, P. H. A.

“…Background Toll like receptors (TLR) play an important role in vein graft disease (VGD). Interferon regulatory factors (IRF) 3 and 7 are the transcriptional…”
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The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease by Simons, K.H., de Vries, M.R., Peters, H.A.B., Hamming, J.F., Jukema, J.W., Quax, P.H.A.

“…Venous grafts are commonly used as conduits to bypass occluded arteries. Unfortunately, patency rates are limited by vein graft disease (VGD). Toll like…”
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RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice by Louwe, M.C, Karper, J.C, de Vries, M.R, Nossent, A.Y, Bastiaansen, A.J.N.M, van der Hoorn, J.W.A, Willems van Dijk, K, Rensen, P.C.N, Steendijk, P, Smit, J.W.A, Quax, P.H.A

“…Abstract Background Toll-like receptor-4 (TLR4), a receptor of the innate immune system, is suggested to have detrimental effects on cardiac function after…”
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The role of CD27-CD70-mediated T cell co-stimulation in vasculogenesis, arteriogenesis and angiogenesis by Simons, K.H., Aref, Z., Peters, H.A.B., Welten, S.P., Nossent, A.Y., Jukema, J.W., Hamming, J.F., Arens, R., de Vries, M.R., Quax, P.H.A.

“…T cells have a distinctive role in neovascularization, which consists of arteriogenesis and angiogenesis under pathological conditions and vasculogenesis under…”
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Variations in Surgical Procedures for Hind Limb Ischaemia Mouse Models Result in differences in Collateral Formation by Hellingman, A.A, Bastiaansen, A.J.N.M, de Vries, M.R, Seghers, L, Lijkwan, M.A, Löwik, C.W, Hamming, J.F, Quax, P.H.A

“…Abstract Objective To identify the optimal mouse model for hind limb ischaemia, which offers a therapeutic window that is large enough to detect improvements…”
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Heat‐killed Staphylococcus aureus reduces atherosclerosis by inducing anti‐inflammatory macrophages by Frodermann, V., Duijn, J., Puijvelde, G. H. M., Santbrink, P. J., Lagraauw, H. M., Vries, M. R., Quax, P. H. A., Bot, I., Foks, A. C., Jager, S. C. A., Kuiper, J.

“…Background Staphylococcus aureus cell wall components can induce IL‐10 responses by immune cells, which may be atheroprotective. Therefore, in this study, we…”
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Elastin is a Key Regulator of Outward Remodeling in Arteriovenous Fistulas by Wong, C.Y, Rothuizen, T.C, de Vries, M.R, Rabelink, T.J, Hamming, J.F, van Zonneveld, A.J, Quax, P.H.A, Rotmans, J.I

“…Objectives Maturation failure is the major limitation of arteriovenous fistulas (AVFs) as hemodialysis access conduits. Indeed, 30–50% of AVFs fail to mature…”
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Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice by Ewing, M.M, Karper, J.C, Sampietro, M.L, de Vries, M.R, Pettersson, K, Jukema, J.W, Quax, P.H.A

“…Highlights ► SNPs in the AnxA5 gene are associated with increased restenosis-risk in PCI patients. ► AnxA5 dose-dependently prevents vascular leukocyte…”
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An Unexpected Intriguing Effect of Toll-Like Receptor Regulator RP105 (CD180) on Atherosclerosis Formation With Alterations on B-Cell Activation by Karper, J.C, de Jager, S.C.A, Ewing, M.M, de Vries, M.R, Bot, I, van Santbrink, P.J, Redeker, A, Mallat, Z, Binder, C.J, Arens, R, Jukema, J.W, Kuiper, J, Quax, P.H.A

“…OBJECTIVE—In atherosclerosis, Toll-like receptors (TLRs) are traditionally linked to effects on tissue macrophages or foam cells. RP105, a structural TLR4…”
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