Search Results - "Quarles, L.D."

Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics by Goodman, William G., Quarles, L.D.

“…The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as the major regulator of parathyroid gland function have important…”
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Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation by Dai, Z., Li, Y., Quarles, L.D., Song, T., Pan, W., Zhou, H., Xiao, Z.

“…In the present study, we investigated the in vitro effect of resveratrol (RSVL), a polyphenolic phytoestrogen, on cell proliferation and osteoblastic…”
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Role of the polycytin-primary cilia complex in bone development and mechanosensing by Xiao, Z.S., Quarles, L.D.

“…Pkd1 encodes PC1, a transmembrane receptor‐like protein, and Pkd2 encodes PC2, a calcium channel, which interact to form functional polycystin complexes that…”
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MEPE has the properties of an osteoblastic phosphatonin and minhibin by Rowe, P.S.N, Kumagai, Y, Gutierrez, G, Garrett, I.R, Blacher, R, Rosen, D, Cundy, J, Navvab, S, Chen, D, Drezner, M.K, Quarles, L.D, Mundy, G.R

“…Matrix extracellular phosphoglycoprotein (MEPE) is expressed exclusively in osteoblasts, osteocytes and odontoblasts with markedly elevated expression found in…”
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Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis by Xiao, Zhou-Sheng, Hjelmeland, Anita B, Quarles, L D

“…Runx2 (runt-related transcription factor 2) is a master regulator of skeletogenesis. Distinct promoters in the Runx2 gene transcribe the "bone-related"…”
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Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor by Xiao, Z.S, Thomas, R, Hinson, T.K, Quarles, L.D

“…Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates osteoblast differentiation, uncertainty exists about the…”
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Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity by Frazão, J M, Messa, P, Mellotte, G J, Geiger, H, Hagen, E C, Quarles, L D, Kerr, P G, Baños, A, Dehmel, B, Urena, P

“…To evaluate the relationship between the severity of secondary hyperparathyroidism (SHPT) - defined in terms of baseline plasma intact parathyroid hormone…”
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Cbfa1 isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and pre-osteoblastic cells by Xiao, Z.S., Hinson, T.K., Quarles, L.D.

“…The mouse Cbfa1 gene potentially encodes several proteins that differ in their N‐terminal sequences, including an osteoblast‐specific transcription factor,…”
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Differentiation of MC3T3-E1 osteoblasts is associated with temporal changes in the expression of IGF-I and IGFBPs by THRAILKILL, K. M, SIDDHANTI, S. R, FOWLKES, J. L, QUARLES, L. D

“…We examined the relationship between osteoblast maturation and temporal changes in the secretion of IGF-I and the IGF-binding proteins (IGFBPs) in the MC3T3-E1…”
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Guanine nucleotide binding‐protein coupled signaling pathway regulation of osteoblast‐mediated bone formation by Quarles, L.D., Siddhanti, S.R.

“…The challenge for successfully treating established osteoporosis is to develop ways to modulate bone remodeling selectively and/or differentially. There are…”
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Identification of Putative Transmembrane Receptor Sequences Homologous to the Calcium-Sensing G-Protein-Coupled Receptor by Hinson, T.K., Damodaran, T.V., Chen, J., Zhang, X., Qumsiyeh, M.B., Seldin, M.F., Quarles, L.D.

“…The sensing of extracellular calcium is a general paradigm for regulating diverse cellular functions in many tissues. A calcium-sensing receptor (Casr)…”
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