Search Results - "Quarles, Darryl Leigh"

Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice by Mackenzie, Neil Charles Wallace, Zhu, Dongxing, Milne, Elspeth M, van 't Hof, Rob, Martin, Aline, Darryl Quarles, Leigh, Quarles, Darryl Leigh, Millán, José Luis, Farquharson, Colin, MacRae, Vicky Elisabeth

“…Nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) is required for the conversion of extracellular ATP into inorganic pyrophosphate (PP(i)), a recognised…”
Get full text

Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages by Han, Xiaobin, Li, Linqiang, Yang, Jiancheng, King, Gwendalyn, Xiao, Zhousheng, Quarles, Leigh Darryl, Ellmeier, Wilfried

“…Mechanisms underlying the association between fibroblastic growth factor 23 (FGF‐23) and inflammation are uncertain. We found that FGF‐23 was markedly…”
Get full text

Physiological mechanisms and therapeutic potential of bone mechanosensing by Xiao, Zhousheng, Quarles, Leigh Darryl

“…Skeletal loading is an important physiological regulator of bone mass. Theoretically, mechanical forces or administration of drugs that activate bone…”
Get full text

Osteocyte-specific deletion of Fgfr1 suppresses FGF23 by Xiao, Zhousheng, Huang, Jinsong, Cao, Li, Liang, Yingjuan, Han, Xiaobin, Quarles, Leigh Darryl

“…Increases in fibroblastic growth factor 23 (FGF23 or Fgf23) production by osteocytes result in hypophosphatemia and rickets in the Hyp mouse homologue of…”
Get full text

Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposity by Xiao, Zhousheng, Cao, Li, Liang, Yingjuan, Huang, Jinsong, Stern, Amber Rath, Dallas, Mark, Johnson, Mark, Quarles, Leigh Darryl

“…Polycystin-1 (Pkd1) interacts with polycystin-2 (Pkd2) to form an interdependent signaling complex. Selective deletion of Pkd1 in the osteoblast lineage…”
Get full text

Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice by Xiao, Zhousheng, Cao, Li, Smith, Micholas Dean, Li, Hanxuan, Li, Wei, Smith, Jeremy C, Quarles, Leigh Darryl

“…Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood. Here, we used mouse genetics,…”
Get full text

Cilia-like Structures and Polycystin-1 in Osteoblasts/Osteocytes and Associated Abnormalities in Skeletogenesis and Runx2 Expression by Xiao, Zhousheng, Zhang, Shiqin, Mahlios, Josh, Zhou, Gan, Magenheimer, Brenda S., Guo, Dayong, Dallas, Sarah L., Maser, Robin, Calvet, James P., Bonewald, Lynda, Quarles, Leigh Darryl

“…We examined the osteoblast/osteocyte expression and function of polycystin-1 (PC1), a transmembrane protein that is a component of the polycystin-2…”
Get full text

Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease by Qiu, Ni, Xiao, Zhousheng, Cao, Li, David, Valentin, Quarles, Leigh Darryl

“…Conditional deletion of Pkd1 in osteoblasts using either Osteocalcin(Oc)-Cre or Dmp1-Cre results in defective osteoblast-mediated postnatal bone formation and…”
Get full text

Genetic Dissection of Femoral and Tibial Microarchitecture by Lu, Lu, Huang, Jinsong, Xu, Fuyi, Xiao, Zhousheng, Wang, Jing, Zhang, Bing, David, Nicolae Valentin, Arends, Danny, Gu, Weikuan, Ackert‐Bicknell, Cheryl, Sabik, Olivia L, Farber, Charles R, Quarles, Leigh Darryl, Williams, Robert W

“…ABSTRACT Our understanding of the genetic control of bone strength has relied mainly on estimates of bone mineral density. Here we have mapped genetic factors…”
Get full text

Correction: Altered Bone Development and an Increase in FGF-23 Expression in Enpp1 −/− Mice by Mackenzie, Neil Charles Wallace, Zhu, Dongxing, Milne, Elspeth M., van 't Hof, Rob, Martin, Aline, Quarles, Darryl Leigh, Millán, José Luis, Farquharson, Colin, MacRae, Vicky Elisabeth

Get full text

Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells by Pi, Min, Kapoor, Karan, Ye, Ruisong, Nishimoto, Satoru Kenneth, Smith, Jeremy C, Baudry, Jerome, Quarles, Leigh Darryl

“…The possibility that G protein-coupled receptor family C member A (GPRC6A) is the osteocalcin (Ocn)-sensing G protein-coupled receptor that directly regulates…”
Get full text

Molecular dynamics analysis of the binding of human interleukin‐6 with interleukin‐6 α‐receptor by Gupta, Madhulika, Ha, Khanh, Agarwal, Rupesh, Quarles, Leigh Darryl, Smith, Jeremy C.

“…Human interleukin‐6 (hIL‐6) is a multifunctional cytokine that regulates immune and inflammatory responses in addition to metabolic and regenerative processes…”
Get full text

Systems genetics and bioinformatics analyses using ESR1-correlated genes identify potential candidates underlying female bone development by Bajpai, Akhilesh K., Gu, Qingqing, Jiao, Yan, Starlard-Davenport, Athena, Gu, Weikuan, Quarles, Leigh Darryl, Xiao, Zhousheng, Lu, Lu

“…Estrogen receptor α (ESR1) is involved in E2 signaling and plays a major role in postmenopausal bone loss. However, the molecular network underlying ESR1 has…”
Get full text

Fibroblast growth factor-23: what we know, what we don't know, and what we need to know by Kovesdy, Csaba P, Quarles, Leigh Darryl

“…Traditional risk factors of cardiovascular morbidity and mortality such as hypertension, hypercholesterolemia and obesity are paradoxically associated with…”
Get full text

The carboxylation status of osteocalcin has important consequences for its structure and dynamics by Kapoor, Karan, Pi, Min, Nishimoto, Satoru Kenneth, Quarles, Leigh Darryl, Baudry, Jerome, Smith, Jeremy C.

“…The carboxylation status of Osteocalcin (Ocn) not only influences formation and structure in bones but also has important endocrine functions affecting energy…”
Get full text

FGF23 expression is stimulated in transgenic α-Klotho longevity mouse model by Xiao, Zhousheng, King, Gwendalyn, Mancarella, Salvatore, Munkhsaikhan, Undral, Cao, Li, Cai, Chun, Quarles, Leigh Darryl

“…Observations in transgenic α-Klotho (Kl) mice (KlTg) defined the antiaging role of soluble Klotho (sKL130). A genetic translocation that elevates sKL levels in…”
Get full text

Novel Small Molecule Fibroblast Growth Factor 23 Inhibitors Increase Serum Phosphate and Improve Skeletal Abnormalities in Hyp Mice by Xiao, Zhousheng, Liu, Jiawang, Liu, Shih-Hsien, Petridis, Loukas, Cai, Chun, Cao, Li, Wang, Guangwei, Chin, Ai Lin, Cleveland, Jacob W, Ikedionwu, Munachi O, Carrick, Jesse D, Smith, Jeremy C, Quarles, Leigh Darryl

“…Excess fibroblast growth factor (FGF) 23 causes hereditary hypophosphatemic rickets, such as X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia…”
Get full text

Genetic interactions between polycystin-1 and Wwtrl in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice by Zhousheng Xiao, Li Cao, Micholas Dean Smith, Hanxuan Li, Wei Li, Jeremy C.Smith, Leigh Darryl Quarles

“…Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood.Here,we used mouse…”
Get full text

Structural and Functional Evidence for Testosterone Activation of GPRC6A in Peripheral Tissues by Pi, Min, Kapoor, Karan, Wu, Yunpeng, Ye, Ruisong, Senogles, Susan E, Nishimoto, Satoru K, Hwang, Dong-Jin, Miller, Duane D, Narayanan, Ramesh, Smith, Jeremy C, Baudry, Jerome, Quarles, L. Darryl

“…G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin. GPRC6A…”
Get full text

Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages by Han, Xiaobin, Li, Linqiang, Yang, Jiancheng, King, Gwendalyn, Xiao, Zhousheng, Quarles, Leigh Darryl

“…Mechanisms underlying the association between fibroblastic growth factor 23 (FGF-23) and inflammation are uncertain. We found that FGF-23 was markedly…”
Get full text