Search Results - "Quarfordt, S H"

Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia by Maeda, N, Li, H, Lee, D, Oliver, P, Quarfordt, S H, Osada, J

“…Using gene targeting in embryonic stem cells, we have generated mice lacking apolipoprotein C-III (ApoC-III). Homozygous mutant animals show absence of…”
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Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice by Zhang, S H, Reddick, R L, Avdievich, E, Surles, L K, Jones, R G, Reynolds, J B, Quarfordt, S H, Maeda, N

“…Dietary administration of probucol (0.5%, wt/wt) efficiently reduced total plasma cholesterol levels in apolipoprotein E-deficient mice (apoE-/-) by 40%, with…”
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Elevated intrahepatic pressures and decreased hepatic tissue blood flow prevent gas embolus during limited laparoscopic liver resections by RICCIARDI, R, ANWARUDDIN, S, SCHAFFER, B. K, QUARFORDT, S. H, DONOHUE, S. E, WHEELER, S. M, GALLAGHER, K. A, CALLERY, M. P, LITWIN, D. E. M, MEYERS, W. C

“…As new techniques are emerging for laparoscopic liver resections, concerns have been raised about the development of gas embolus related to the CO(2)…”
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In vivo cholesterol kinetics in apolipoprotein E-deficient and control mice by Quarfordt, S H, Oswald, B, Landis, B, Xu, H S, Zhang, S H, Maeda, N

“…The in vivo total body cholesterol transport of homozygous apoE-deficient (-/-) and control (+/+) mice was evaluated by compartmental analysis of plasma…”
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Biliary secretion of extracorporeal porcine livers with single and dual vessel perfusion by FOLEY, D. P, VITTIMBERGA, F. J, QUARFORDT, S. H, DONOHUE, S. E, TRAYLOR, A. N, MACPHEE, J, MCLAUGHLIN, T, RICCIARDI, R, CALLERY, M. P, MEYERS, W. C

“…Hepatic support systems that provide detoxification without biliary secretion (i.e., isolated hepatocyte systems) are sufficient to improve encephalopathy and…”
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Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe2 by Sullivan, P M, Mezdour, H, Quarfordt, S H, Maeda, N

“…To study isoform-specific effects of apolipoprotein E (apoE) in vivo, we generated mice with a human APOE*2 allele in place of the mouse Apoe gene via targeted…”
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Apo E structure determines VLDL clearance and atherosclerosis risk in mice by Knouff, C, Hinsdale, M E, Mezdour, H, Altenburg, M K, Watanabe, M, Quarfordt, S H, Sullivan, P M, Maeda, N

“…We have generated mice expressing the human apo E4 isoform in place of the endogenous murine apo E protein and have compared them with mice expressing the…”
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Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis by Sullivan, Patrick M., Mezdour, Hafid, Aratani, Yasuaki, Knouff, Chris, Najib, Jamila, Reddick, Robert L., Quarfordt, Steven H., Maeda, Nobuyo

“…Apolipoprotein (apo) E, a constituent of several lipoproteins, is a ligand for the low density lipoprotein receptor, and this interaction is important for…”
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NFκB Expression during Cold Ischemia Correlates with Postreperfusion Graft Function by Ricciardi, R., Kim, R.D., McDade, T.P., Perugini, R.A., Veal, T.M., Quarfordt, S.H., Callery, M.P., Chari, R.S., Meyers, W.C.

“…In liver transplantation, activation of NFκB occurs upon reperfusion, yet few data exist regarding NFκB activation during cold ischemia. We hypothesized that…”
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Pathogenesis of hepatic steatosis in the parenterally fed rat by HALL, R. I, GRANT, J. P, ROSS, L. H, COLEMAN, R. A, BOZOVIC, M. G, QUARFORDT, S. H

“…Hepatic steatosis frequently complicates total parenteral nutrition (TPN). Some of the mechanisms responsible were examined in rats receiving calories as…”
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The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat by Quarfordt, S H, Michalopoulos, G, Schirmer, B

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Apolipoprotein effects on the lipolysis of perfused triglyceride by heparin-immobilized milk lipase by Clark, A B, Quarfordt, S H

“…Bovine milk lipase was noncovalently bound to a heparin-Sepharose support and a [3H]glycerol/[14C]triolein emulsion was circulated through it. This system,…”
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Influence of apolipoprotein E on soluble and heparin-immobilized hepatic lipase by Landis, B A, Rotolo, F S, Meyers, W C, Clark, A B, Quarfordt, S H

“…The effect of human apolipoprotein E (apoE), either alone or in combination with apoC, on the lipolysis of a radiolabeled triglyceride emulsion was studied…”
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Transport of free fatty acid and triglyceride in anhepatic rats by Quarfordt, S H, DeFaria, E, Landis, B A, Bollinger, R R, Yamaguchi, Y

“…Without a liver the fractional plasma removal of free fatty acid is one third and chylomicron triglyceride one half of that in the intact rat. The intestine of…”
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Plasma cholesterol transport in anhepatic rats by QUARFORDT, S. H, LANDIS, B, CUCCHIARO, G, YAMAGUCHI, Y, OSWALD, B

“…The plasma appearance of newly synthesized cholesterol in anhepatic laboratory diet-fed rats was 10% of the intact rat. In intact rats this cholesterol was…”
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V-PYRRO/NO: An hepato-selective nitric oxide donor improves porcine liver hemodynamics and function after ischemia reperfusion by RICCIARDI, Rocco, FOLEY, David P, QUARFORDT, Steven H, SAAVEDRA, Joseph E, KEEFER, Larry K, WHEELER, Suzanne M, DONOHUE, Susan E, CALLERY, Mark P, MEYERS, William C

“…The role of nitric oxide (NO) in ischemia reperfusion (I/R) injury is controversial as both beneficial and harmful effects have been reported. We explored the…”
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Plasma lipoproteins after triglyceride clearance in cholesterol-fed rats by QUARFORDT, S. H, OSWALD, B. S, FAROUK, M. O, WEHRENBERG, D. C, MORTON, E. B, LANDIS, B. A

“…The clearance of particulate triglyceride from the plasma of cholesterol-fed rats with appreciable stores of hepatic cholesterol ester produces a substantial…”
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Alterations of rat hepatic cholesterogenesis by heterologous lipoproteins by Jakoi, L, Quarfordt, S H

“…Heterologous human lipoproteins were infused into rats in order to change acutely the lipoprotein pattern to a predominant kind and the effect on hepatic…”
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Regulation of biliary protein secretion in dogs by Rotolo, F S, Watters, C R, Xu, H, Quarfordt, S H, Meyers, W C

“…The biliary secretion of protein in response to bile acids and other agents known to increase bile flow was examined in a chronic bile fistula dog model…”
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Protective effects of ischemic preconditioning on the cold-preserved liver are tyrosine kinase dependent by RICCIARDI, Rocco, SCHAFFER, Bradley K, KIM, Robin D, SHAH, Shimul A, DONOHUE, Susan E, WHEELER, Suzanne M, QUARFORDT, Steven H, GALLERY, Mark P, MEYERS, William C, CHARI, Ravi S

“…Little data exist regarding the use of ischemic preconditioning before sustained hepatic cold storage. We hypothesized that ischemic preconditioning protects…”
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