Search Results - "Quantock, Andrew J."

Co-ordinated ocular development from human iPS cells and recovery of corneal function by Hayashi, Ryuhei, Ishikawa, Yuki, Sasamoto, Yuzuru, Katori, Ryosuke, Nomura, Naoki, Ichikawa, Tatsuya, Araki, Saori, Soma, Takeshi, Kawasaki, Satoshi, Sekiguchi, Kiyotoshi, Quantock, Andrew J., Tsujikawa, Motokazu, Nishida, Kohji

“…A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell…”
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Generation of 3D lacrimal gland organoids from human pluripotent stem cells by Hayashi, Ryuhei, Okubo, Toru, Kudo, Yuji, Ishikawa, Yuki, Imaizumi, Tsutomu, Suzuki, Kenji, Shibata, Shun, Katayama, Tomohiko, Park, Sung-Joon, Young, Robert D., Quantock, Andrew J., Nishida, Kohji

“…Lacrimal glands are the main exocrine glands of the eyes. Situated within the orbit, behind the upper eyelid and towards the temporal side of each eye, they…”
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Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells by Hayashi, Ryuhei, Ishikawa, Yuki, Katori, Ryousuke, Sasamoto, Yuzuru, Taniwaki, Yuki, Takayanagi, Hiroshi, Tsujikawa, Motokazu, Sekiguchi, Kiyotoshi, Quantock, Andrew J, Nishida, Kohji

“…This protocol describes how to grow a functional and transplantable corneal epithelium and how to generate ocular-like cell lineages resembling neuroectoderm,…”
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CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells by Hayashi, Ryuhei, Ishikawa, Yuki, Katayama, Tomohiko, Quantock, Andrew J., Nishida, Kohji

“…The in vitro induction of corneal epithelial cells (CECs) from human induced pluripotent stem cells (iPSCs) represents a new strategy for obtaining CE…”
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Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs by Nomi, Kimihito, Hayashi, Ryuhei, Ishikawa, Yuki, Kobayashi, Yuki, Katayama, Tomohiko, Quantock, Andrew J., Nishida, Kohji

“…The conjunctival epithelium, which covers the sclera (the white of the eye) and lines the inside of the eyelids, is essential for mucin secretion and the…”
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The effect of riboflavin/UVA collagen cross-linking therapy on the structure and hydrodynamic behaviour of the ungulate and rabbit corneal stroma by Hayes, Sally, Kamma-Lorger, Christina S, Boote, Craig, Young, Robert D, Quantock, Andrew J, Rost, Anika, Khatib, Yasmeen, Harris, Jonathan, Yagi, Naoto, Terrill, Nicholas, Meek, Keith M

“…To examine the effect of riboflavin/UVA corneal crosslinking on stromal ultrastructure and hydrodynamic behaviour. One hundred and seventeen enucleated…”
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Ocular surface ectoderm instigated by WNT inhibition and BMP4 by Kobayashi, Yuki, Hayashi, Ryuhei, Shibata, Shun, Quantock, Andrew J., Nishida, Kohji

“…[Display omitted] •Ocular surface ectodermal fate is determined in the early stage of human eye development.•p63+ cells which co-express PAX6, are seen in the…”
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Developmental Changes in Patterns of Distribution of Fibronectin and Tenascin-C in the Chicken Cornea: Evidence for Distinct and Independent Functions during Corneal Development and Morphogenesis by Koudouna, Elena, Young, Robert D, Quantock, Andrew J, Ralphs, James R

“…The cornea forms the tough and transparent anterior part of the eye and by accurate shaping forms the major refractive element for vision. Its largest…”
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Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages by Shibata, Shun, Hayashi, Ryuhei, Okubo, Toru, Kudo, Yuji, Katayama, Tomohiko, Ishikawa, Yuki, Toga, Junko, Yagi, Emiko, Honma, Yoichi, Quantock, Andrew J., Sekiguchi, Kiyotoshi, Nishida, Kohji

“…The extracellular matrix plays a key role in stem cell maintenance, expansion, and differentiation. Laminin, a basement membrane protein, is a widely used…”
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Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy by Okumura, Naoki, Minamiyama, Ryuki, Ho, Leona TY, Kay, EunDuck P, Kawasaki, Satoshi, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich E, Young, Robert D, Quantock, Andrew J, Kinoshita, Shigeru, Koizumi, Noriko

“…Fuchs endothelial corneal dystrophy (FECD) due to corneal endothelial cell degeneration is a major cause of corneal transplantation. It is characterized by…”
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Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy by Okumura, Naoki, Kitahara, Miu, Okuda, Hirokazu, Hashimoto, Keisuke, Ueda, Emi, Nakahara, Makiko, Kinoshita, Shigeru, Young, Robert D, Quantock, Andrew J, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Koizumi, Noriko

“…The unfolded protein response (UPR) is believed to play a role in the pathogenesis of Fuchs' endothelial corneal dystrophy (FECD). The purpose of this study…”
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Imaging three-dimensional tissue architectures by focused ion beam scanning electron microscopy by Bushby, Andrew J, P'ng, Kenneth M Y, Young, Robert D, Pinali, Christian, Knupp, Carlo, Quantock, Andrew J

“…In this protocol, we describe a 3D imaging technique known as 'volume electron microscopy' or 'focused ion beam scanning electron microscopy (FIB/SEM)' applied…”
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Ultraviolet Light Transmission through the Human Corneal Stroma Is Reduced in the Periphery by Doutch, James J., Quantock, Andrew J., Joyce, Nancy C., Meek, Keith M.

“…This article investigates in vitro light transmission through the human cornea in the ultraviolet (UV) portion of the electromagnetic spectrum as a function of…”
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Chondroitin Sulphate/Dermatan Sulphate Proteoglycans: Potential Regulators of Corneal Stem/Progenitor Cell Phenotype In Vitro by Bains, Kiranjit K, Ashworth, Sean, Koudouna, Elena, Young, Robert D, Hughes, Clare E, Quantock, Andrew J

“…Chondroitin sulphate (CS) proteoglycans with variable sulphation-motifs along their glycosaminoglycan (GAG) chains are closely associated with the stem cell…”
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Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis by Morgan, Siân R., Pilia, Nicole, Hewitt, Melissa, Moses, Rachael L., Moseley, Ryan, Lewis, Philip N., Morrison, Peter W.J., Kelly, Steven L., Parker, Josie E., Whitaker, David, Quantock, Andrew J., Heard, Charles M.

“…[Display omitted] Acanthamoeba keratitis is caused by a protozoal infection of the cornea, with 80% of cases involving the improper use of contact lenses. The…”
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Three-dimensional aspects of matrix assembly by cells in the developing cornea by Young, Robert D., Knupp, Carlo, Pinali, Christian, Png, Kenneth M.Y., Ralphs, James R., Bushby, Andrew J., Starborg, Tobias, Kadler, Karl E., Quantock, Andrew J.

“…Cell-directed deposition of aligned collagen fibrils during corneal embryogenesis is poorly understood, despite the fact that it is the basis for the formation…”
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Assessment of a self-assembling peptide gel, SPG-178, in providing a clear operative field for trabeculectomy surgery for glaucoma in an animal model by Matsushita, Kenji, Kawashima, Rumi, Uesugi, Koji, Okada, Haruka, Sakaguchi, Hirokazu, Quantock, Andrew J., Nishida, Kohji

“…The presence of blood during ophthalmic surgery is problematic, as it can obstruct a surgeon’s view of the operative field. This is particularly true when…”
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Barium-induced toxic anterior segment syndrome by Matsushita, Kenji, Kawashima, Rumi, Hashida, Noriyasu, Hamano, Yuki, Harada, Kazuo, Higashisaka, Kazuma, Baba, Koichi, Sato, Shigeru, Huang, Weiran, Matsumoto, Hiroshi, Hamanaka, Teruhiko, Quantock, Andrew J., Nishida, Kohji

“…Toxic anterior segment syndrome (TASS) is a rapid-onset inflammation of the eye following uneventful ocular surgery. We report a case of TASS following…”
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Recovering vision in corneal epithelial stem cell deficient eyes by Bains, Kiranjit K., Fukuoka, Hideki, Hammond, Greg M., Sotozono, Chie, Quantock, Andrew J.

“…•Corneal limbal epithelial stem cells deficiencies cause severe ocular surface instability and visual impairment.•These conditions, caused by injury or…”
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Structural Interactions between Collagen and Proteoglycans Are Elucidated by Three-Dimensional Electron Tomography of Bovine Cornea by Lewis, Philip N., Pinali, Christian, Young, Robert D., Meek, Keith M., Quantock, Andrew J., Knupp, Carlo

“…Interactions between collagens and proteoglycans help define the structure and function of extracellular matrices. The cornea, which contains proteoglycans…”
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