Search Results - "Quan, Erin M"

Comprehensive Characterization of Genes Required for Protein Folding in the Endoplasmic Reticulum by Jonikas, Martin C, Collins, Sean R, Denic, Vladimir, Oh, Eugene, Quan, Erin M, Schmid, Volker, Weibezahn, Jimena, Schwappach, Blanche, Walter, Peter, Weissman, Jonathan S, Schuldiner, Maya

“…Protein folding in the endoplasmic reticulum is a complex process whose malfunction is implicated in disease and aging. By using the cell's endogenous sensor…”
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Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation by Quan, Erin M., Kamiya, Yukiko, Kamiya, Daiki, Denic, Vladimir, Weibezahn, Jimena, Kato, Koichi, Weissman, Jonathan S.

“…The endoplasmic reticulum (ER) must target potentially toxic misfolded proteins for retrotranslocation and proteasomal degradation while avoiding destruction…”
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Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER Lumen by Bhamidipati, Arunashree, Denic, Vladimir, Quan, Erin M., Weissman, Jonathan S.

“…ER-associated degradation (ERAD) of glycoproteins depends on dual recognition of protein misfolding and remodeling of the substrate’s N-linked glycans. After…”
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A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for ER-Associated Degradation by Denic, Vladimir, Quan, Erin M., Weissman, Jonathan S.

“…How the ER-associated degradation (ERAD) machinery accurately identifies terminally misfolded proteins is poorly understood. For luminal ERAD substrates, this…”
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