Search Results - "Quan, Chengshi"

CLDN6: From Traditional Barrier Function to Emerging Roles in Cancers by Qu, Huinan, Jin, Qiu, Quan, Chengshi

“…Claudins (CLDNs) are the most important tight junction proteins, which are mainly expressed in endothelial cells or epithelial cells in a tissue-specific…”
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NPFs-mediated actin cytoskeleton: a new viewpoint on autophagy regulation by Dong, Yuan, Quan, Chengshi

“…Macroautophagy/autophagy is a lysosome-dependent catabolic process induced by various cellular stress conditions, maintaining the homeostasis of cells, tissues…”
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Claudins and hepatocellular carcinoma by Wang, Wentao, Zhou, Yi, Li, Wei, Quan, Chengshi, Li, Yanru

“…Hepatocellular carcinoma (HCC) has a high incidence and dismal prognosis, making it a significant global health burden. To change this, the development of new…”
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New insights into the regulation of METTL3 and its role in tumors by Jin, Qiu, Qu, Huinan, Quan, Chengshi

“…As one of the most abundant epigenetic modifications in RNA, N -methyladenosine (m A) affects RNA transcription, splicing, stability, and posttranscriptional…”
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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy by Song, Peiye, Li, Yanru, Dong, Yuan, Liang, Yingying, Qu, Huinan, Qi, Da, Lu, Yan, Jin, Xiangshu, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Xu, Wenhong, Quan, Chengshi

“…Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not…”
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CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation by Jin, Qiu, Qi, Da, Zhang, Mingzi, Qu, Huinan, Dong, Yuan, Sun, Minghao, Quan, Chengshi

“…Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide, with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor…”
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CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy by Dong, Yuan, Jin, Qiu, Sun, Minghao, Qi, Da, Qu, Huinan, Wang, Xinqi, Quan, Chengshi

“…As a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the specific mechanism…”
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CLDN6 Suppresses c-MYC-Mediated Aerobic Glycolysis to Inhibit Proliferation by TAZ in Breast Cancer by Qu, Huinan, Qi, Da, Wang, Xinqi, Dong, Yuan, Jin, Qiu, Wei, Junyuan, Quan, Chengshi

“…Claudin 6 (CLDN6) was found to be a breast cancer suppressor gene, which is lowly expressed in breast cancer and inhibits breast cancer cell proliferation upon…”
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MiR-124 and Small Molecules Synergistically Regulate the Generation of Neuronal Cells from Rat Cortical Reactive Astrocytes by Zheng, Yangyang, Huang, Zhehao, Xu, Jinying, Hou, Kun, Yu, Yifei, Lv, Shuang, Chen, Lin, Li, Yulin, Quan, Chengshi, Chi, Guangfan

“…Irreversible neuron loss caused by central nervous system injuries usually leads to persistent neurological dysfunction. Reactive astrocytes, because of their…”
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A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis by Jia, Yiyang, Guo, Yantong, Jin, Qiu, Qu, Huinan, Qi, Da, Song, Peiye, Zhang, Xiaoli, Wang, Xinqi, Xu, Wenhong, Dong, Yuan, Liang, Yingying, Quan, Chengshi

“…We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly…”
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OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases by Lu, Yan, Qu, Huinan, Qi, Da, Xu, Wenhong, Liu, Shutong, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Li, Hairi, Li, Yulin, Quan, Chengshi

“…Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by…”
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DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac by Liu, Yafang, Jin, Xiangshu, Li, Yanru, Ruan, Yang, Lu, Yan, Yang, Minlan, Lin, Dongjing, Song, Peiye, Guo, Yantong, Zhao, Shuai, Dong, Bing, Xie, Yinping, Dang, Qihua, Quan, Chengshi

“…Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell…”
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SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells by Lu, Yan, Wang, Liping, Li, Hairi, Li, Yanru, Ruan, Yang, Lin, Dongjing, Yang, Minlan, Jin, Xiangshu, Guo, Yantong, Zhang, Xiaoli, Quan, Chengshi

“…The downregulation of tight junction protein CLDN6 promotes breast cancer cell migration and invasion; however, the exact mechanism underlying CLDN6…”
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Independent prognostic value of CLDN6 in bladder cancer based on M2 macrophages related signature by Qi, Da, Lu, Yan, Qu, Huinan, Dong, Yuan, Jin, Qiu, Sun, Minghao, Li, Yanru, Quan, Chengshi

“…M2 macrophages are associated with the prognosis of bladder cancer. CLDN6 has been linked to immune infiltration and is crucial for predicting the prognosis in…”
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Mechanisms underlying cancer growth and apoptosis by DEK overexpression in colorectal cancer by Lin, Lijuan, Piao, Junjie, Ma, Yibing, Jin, Tiefeng, Quan, Chengshi, Kong, Jienan, Li, Yulin, Lin, Zhenhua

“…Our previous study indicated that DEK protein was overexpressed in colorectal carcinoma (CRC) compared with the normal colorectal mucosa. DEK was also…”
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Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell by Ren, Yue, Dashtsoodol, Nyambayar, Watarai, Hiroshi, Koseki, Haruhiko, Quan, Chengshi, Taniguchi, Masaru

“…NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells…”
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Splicing factor Srsf5 deletion disrupts alternative splicing and causes noncompaction of ventricular myocardium by Zhang, Xiaoli, Wang, Ze, Xu, Qing, Chen, Yuhan, Liu, Wen, Zhong, Tong, Li, Hongchang, Quan, Chengshi, Zhang, Lingqiang, Cui, Chun-Ping

“…The serine/arginine-rich (SR) family of splicing factors plays important roles in mRNA splicing activation, repression, export, stabilization, and translation…”
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CLDN6 promotes chemoresistance through GSTP1 in human breast cancer by Yang, Minlan, Li, Yanru, Shen, Xiangfeng, Ruan, Yang, Lu, Yan, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Zhang, Xiaoli, Qu, Huinan, Shao, Yijia, Quan, Chengshi

“…Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer…”
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Clinicopathologic significance of claudin-6, occludin, and matrix metalloproteinases -2 expression in ovarian carcinoma by Wang, Liping, Jin, Xiangshu, Lin, Dongjing, Liu, Zhijing, Zhang, Xiaowei, Lu, Yan, Liu, Yuanyuan, Wang, Min, Yang, Minlan, Li, Jiuxia, Quan, Chengshi

“…Tight junctions (TJs) are mainly composed of claudins, occludin, and tight junction adhesion molecules (JAM). The invasive and metastatic phenotype of highly…”
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The distinct expression patterns of claudin-2, -6, and -11 between human gastric neoplasms and adjacent non-neoplastic tissues by Lin, Zhe, Zhang, Xiaowei, Liu, Zhijing, Liu, Qihui, Wang, Liping, Lu, Yan, Liu, Yuanyuan, Wang, Min, Yang, Minlan, Jin, Xiangshu, Quan, Chengshi

“…Cancers have a multifactorial etiology a part of which is genetic. Recent data indicate that expression of the tight junction claudin proteins is involved in…”
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