Search Results - "Quail, Daniela F"

Molecular Pathways: Deciphering Mechanisms of Resistance to Macrophage-Targeted Therapies by Quail, Daniela F, Joyce, Johanna A

“…Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor types. TAM-targeted therapies include depletion strategies, inhibiting…”
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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas by Quail, Daniela F., Bowman, Robert L., Akkari, Leila, Quick, Marsha L., Schuhmacher, Alberto J., Huse, Jason T., Holland, Eric C., Sutton, James C., Joyce, Johanna A.

“…Macrophages accumulate with glioblastoma multiforme (GBM) progression and can be targeted via inhibition of colony-stimulating factor-1 receptor (CSF-1R) to…”
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Obesity and the tumor microenvironment by Olson, Oakley C., Quail, Daniela F., Joyce, Johanna A.

“…Obesity-associated inflammation promotes tumor growth and metastatic spread Obesity is a growing global epidemic and rivals smoking as the leading preventable…”
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Single-cell spatial landscapes of the lung tumour immune microenvironment by Sorin, Mark, Rezanejad, Morteza, Karimi, Elham, Fiset, Benoit, Desharnais, Lysanne, Perus, Lucas J. M., Milette, Simon, Yu, Miranda W., Maritan, Sarah M., Doré, Samuel, Pichette, Émilie, Enlow, William, Gagné, Andréanne, Wei, Yuhong, Orain, Michele, Manem, Venkata S. K., Rayes, Roni, Siegel, Peter M., Camilleri-Broët, Sophie, Fiset, Pierre Olivier, Desmeules, Patrice, Spicer, Jonathan D., Quail, Daniela F., Joubert, Philippe, Walsh, Logan A.

“…Single-cell technologies have revealed the complexity of the tumour immune microenvironment with unparalleled resolution 1 – 9 . Most clinical strategies rely…”
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CSF-1R inhibition alters macrophage polarization and blocks glioma progression by Pyonteck, Stephanie M, Akkari, Leila, Schuhmacher, Alberto J, Bowman, Robert L, Sevenich, Lisa, Quail, Daniela F, Olson, Oakley C, Quick, Marsha L, Huse, Jason T, Teijeiro, Virginia, Setty, Manu, Leslie, Christina S, Oei, Yoko, Pedraza, Alicia, Zhang, Jianan, Brennan, Cameron W, Sutton, James C, Holland, Eric C, Daniel, Dylan, Joyce, Johanna A

“…The authors provide preclinical testing of a CSFR-1 inhibitor in proneural glioma models. The compound targets macrophages in the tumor microenvironment rather…”
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Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF by Quail, Daniela F., Olson, Oakley C., Bhardwaj, Priya, Walsh, Logan A., Akkari, Leila, Quick, Marsha L., Chen, I-Chun, Wendel, Nils, Ben-Chetrit, Nir, Walker, Jeanne, Holt, Peter R., Dannenberg, Andrew J., Joyce, Johanna A.

“…Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between…”
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Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents by Olson, Oakley C., Kim, Hyunjung, Quail, Daniela F., Foley, Emily A., Joyce, Johanna A.

“…Antimitotic agents, including Taxol, disrupt microtubule dynamics and cause a protracted mitotic arrest and subsequent cell death. Despite the broad utility of…”
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Translational control of breast cancer plasticity by Jewer, Michael, Lee, Laura, Leibovitch, Matthew, Zhang, Guihua, Liu, Jiahui, Findlay, Scott D., Vincent, Krista M., Tandoc, Kristofferson, Dieters-Castator, Dylan, Quail, Daniela F., Dutta, Indrani, Coatham, Mackenzie, Xu, Zhihua, Puri, Aakshi, Guan, Bo-Jhih, Hatzoglou, Maria, Brumwell, Andrea, Uniacke, James, Patsis, Christos, Koromilas, Antonis, Schueler, Julia, Siegers, Gabrielle M., Topisirovic, Ivan, Postovit, Lynne-Marie

“…Plasticity of neoplasia, whereby cancer cells attain stem-cell-like properties, is required for disease progression and represents a major therapeutic…”
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Immunological Regulation of Vascular Inflammation During Cancer Metastasis by McDowell, Sheri A C, Quail, Daniela F

“…Metastasis is the predominant cause of cancer-related mortality, despite being a highly inefficient process overall. The vasculature is the gatekeeper for…”
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Immunotherapy for Glioblastoma: Current Progress and Challenges by Yu, Miranda W., Quail, Daniela F.

“…Glioblastoma is a highly lethal brain cancer with a median survival rate of less than 15 months when treated with the current standard of care, which consists…”
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Microenvironmental regulation of cancer stem cell phenotypes by Quail, Daniela F, Taylor, Meghan J, Postovit, Lynne-Marie

“…Cancer is a complex set of diseases, driven by genomic instability overlaid with epigenetic modifications. Two prevailing concepts, the stochastic theory and…”
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The Microenvironmental Landscape of Brain Tumors by Quail, Daniela F., Joyce, Johanna A.

“…The brain tumor microenvironment (TME) is emerging as a critical regulator of cancer progression in primary and metastatic brain malignancies. The unique…”
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The obese adipose tissue microenvironment in cancer development and progression by Quail, Daniela F., Dannenberg, Andrew J.

“…Obesity is associated with both increased cancer incidence and progression in multiple tumour types, and is estimated to contribute to up to 20% of…”
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Microenvironmental regulation of tumor progression and metastasis by Quail, Daniela F, Joyce, Johanna A

“…Cancer cells can alter and build a permissive microenvironment that supports the malignant behavior of a growing primary tumor and developing metastases. But…”
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Fueling the Tumor Microenvironment with Cancer-Associated Adipocytes by Bouche, Caroline, Quail, Daniela F

“…Despite their abundance throughout the body, adipocytes are often ignored for their contributions within the tumor microenvironment (TME). However, their role…”
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Single-cell spatial landscape of immunotherapy response reveals mechanisms of CXCL13 enhanced antitumor immunity by Sorin, Mark, Karimi, Elham, Rezanejad, Morteza, Yu, Miranda W, Desharnais, Lysanne, McDowell, Sheri A C, Doré, Samuel, Arabzadeh, Azadeh, Breton, Valerie, Fiset, Benoit, Wei, Yuhong, Rayes, Roni, Orain, Michele, Coulombe, Francois, Manem, Venkata S K, Gagne, Andreanne, Quail, Daniela F, Joubert, Philippe, Spicer, Jonathan D, Walsh, Logan A

“…BackgroundImmunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable…”
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Spatial computational modelling illuminates the role of the tumour microenvironment for treating glioblastoma with immunotherapies by Mongeon, Blanche, Hébert-Doutreloux, Julien, Surendran, Anudeep, Karimi, Elham, Fiset, Benoit, Quail, Daniela F., Walsh, Logan A., Jenner, Adrianne L., Craig, Morgan

“…Glioblastoma is the most common and deadliest brain tumour in adults, with a median survival of 15 months under the current standard of care. Immunotherapies…”
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Embryonic morphogen nodal promotes breast cancer growth and progression by Quail, Daniela F, Zhang, Guihua, Walsh, Logan A, Siegers, Gabrielle M, Dieters-Castator, Dylan Z, Findlay, Scott D, Broughton, Heather, Putman, David M, Hess, David A, Postovit, Lynne-Marie

“…Breast cancers expressing human embryonic stem cell (hESC)-associated genes are more likely to progress than well-differentiated cancers and are thus…”
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Decoding the tumor microenvironment with spatial technologies by Walsh, Logan A., Quail, Daniela F.

“…Visualization of the cellular heterogeneity and spatial architecture of the tumor microenvironment (TME) is becoming increasingly important to understand…”
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Exercise-dependent regulation of the tumour microenvironment by Koelwyn, Graeme J., Quail, Daniela F., Zhang, Xiang, White, Richard M., Jones, Lee W.

“…Emerging data indicate that exercise modulates cancer biology and disease outcomes; however, the molecular mechanisms are poorly established. In this Opinion…”
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