Search Results - "Quadros, Helenita C."

The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs by Quadros, Helenita C, Silva, Mariana C B, Moreira, Diogo R M

“…has evolved to regulate the levels and oxidative states of iron protoporphyrin IX (Fe-PPIX). Antimalarial endoperoxides such as 1,2,4-trioxane artemisinin and…”
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Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the Plasmodium Life Cycle by Quadros, Helenita C., Çapcı, Aysun, Herrmann, Lars, D’Alessandro, Sarah, Fontinha, Diana, Azevedo, Raquel, Villarreal, Wilmer, Basilico, Nicoletta, Prudêncio, Miguel, Tsogoeva, Svetlana B., Moreira, Diogo R. M.

“…A recently developed artemisinin-quinoline hybrid, named 163A, has been shown to display potent activity against the asexual blood stage of Plasmodium, the…”
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Access to Artemisinin–Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity against Multi-Drug-Resistant Malaria Parasites by Herrmann, Lars, Leidenberger, Maria, Quadros, Helenita C., Grau, Benedikt W., Hampel, Frank, Friedrich, Oliver, Moreira, Diogo R. M., Kappes, Barbara, Tsogoeva, Svetlana B.

“…Malaria is one of the most widespread diseases worldwide. Besides a growing number of people potentially threatened by malaria, the consistent emergence of…”
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Development and Characterization of PLGA Nanoparticles Containing 17-DMAG, an Hsp90 Inhibitor by Cruz, Kercia P, Patricio, Beatriz F C, Pires, Vinícius C, Amorim, Marina F, Pinho, Alan G S F, Quadros, Helenita C, Dantas, Diana A S, Chaves, Marcelo H C, Formiga, Fabio R, Rocha, Helvécio V A, Veras, Patrícia S T

“…Leishmaniasis is a spectrum of neglected tropical diseases and its cutaneous form (CL) is characterized by papillary or ulcerated skin lesions that negatively…”
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Use of the gonadal tissue of the sea urchin Paracentrotus lividus as a target for environmental contamination by trace metals by Sarly, Monique S., Pedro, Carmen A., Bruno, Catarina S., Raposo, Andreia, Quadros, Helenita C., Pombo, Ana, Gonçalves, Sílvia C.

“…Many environmental monitoring works have been carried out using biomarkers as a tool to identify the effects of oil contamination on marine organisms; however,…”
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Antimalarial Pyrido[1,2‑a]benzimidazoles Exert Strong Parasiticidal Effects by Achieving High Cellular Uptake and Suppressing Heme Detoxification by Sousa, Caroline C., Dziwornu, Godwin Akpeko, Quadros, Helenita C., Araujo-Neto, João Honorato, Chibale, Kelly, Moreira, Diogo R. M.

“…Pyrido­[1,2-a]­benzimidazoles (PBIs) are synthetic antiplasmodium agents with potent activity and are structurally differentiated from benchmark antimalarials…”
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A bis-indazolic ruthenium(II) complex: Reactivity and biological studies on cancer cells by Sales, Danilo K.S., Simplício, Lílian M.T., da Silva, Carlos D.S., Enju, Carolina M.B., Silva, Vanessa B., Paulo, Tércio de F., Santos, Ivanilson P., Quadros, Helenita C., Meira, Cássio S., Soares, Milena B.P., Lopes, Luiz G. de F., de Sousa, Eduardo H.S., de Sá, Denise S.

“…A new KP1339 analogue ruthenium complex, cis-[Ru(Hind)2(bpy)2](PF6)2, showed expressive cytotoxicity against liver cancer cells, HepG2, causing DNA…”
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