Search Results - "Quadros, Edward V."

Folate and Other B Vitamins in Brain Health and Disease by Quadros, Edward V

“…B vitamins as a group play essential roles in a multitude of metabolic reactions involved in cellular replication, energy production, the synthesis of…”
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The metabolic basis for developmental disorders due to defective folate transport by Desai, Ankuri, Sequeira, Jeffrey M., Quadros, Edward V.

“…Folates are essential in the intermediary metabolism of amino acids, synthesis of nucleotides and for maintaining methylation reactions. They are also linked…”
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Cerebral Folate Deficiency Syndrome: Early Diagnosis, Intervention and Treatment Strategies by Ramaekers, Vincent Th, Quadros, Edward V.

“…Cerebral folate deficiency syndrome (CFDS) is defined as any neuropsychiatric or developmental disorder characterized by decreased CSF folate levels in the…”
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Brain Uptake of Folate Forms in the Presence of Folate Receptor Alpha Antibodies in Young Rats: Folate and Antibody Distribution by Bobrowski-Khoury, Natasha, Sequeira, Jeffrey M, Quadros, Edward V

“…In a rat model, following exposure to rat folate receptor alpha antibodies (FRαAb) during gestation, FRαAb accumulates in the placenta and the fetus and blocks…”
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FTY720 requires vitamin B12-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis by Jonnalagadda, Deepa, Kihara, Yasuyuki, Groves, Aran, Ray, Manisha, Saha, Arjun, Ellington, Clayton, Lee-Okada, Hyeon-Cheol, Furihata, Tomomi, Yokomizo, Takehiko, Quadros, Edward V., Rivera, Richard, Chun, Jerold

“…Vitamin B12 (B12) deficiency causes neurological manifestations resembling multiple sclerosis (MS); however, a molecular explanation for the similarity is…”
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Absorption and Tissue Distribution of Folate Forms in Rats: Indications for Specific Folate Form Supplementation during Pregnancy by Bobrowski-Khoury, Natasha, Sequeira, Jeffrey M, Arning, Erland, Bottiglieri, Teodoro, Quadros, Edward V

“…Food fortification and folic acid supplementation during pregnancy have been implemented as strategies to prevent fetal malformations during pregnancy…”
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Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study by Sequeira, Jeffrey M, Desai, Ankuri, Berrocal-Zaragoza, Maria I, Murphy, Michelle M, Fernandez-Ballart, Joan D, Quadros, Edward V

“…The central nervous system continues to develop during gestation and after birth, and folate is an essential nutrient in this process. Folate deficiency and…”
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Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse by Arora, Kaveri, Sequeira, Jeffrey M, Hernández, Alejandro I, Alarcon, Juan M, Quadros, Edward V

“…Vitamin B12 (cobalamin) deficiency is prevalent worldwide and causes megaloblastic anemia and neurologic deficits. While the anemia can be treated, the…”
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Clinical recognition and aspects of the cerebral folate deficiency syndromes by Ramaekers, Vincent, Sequeira, Jeffrey M, Quadros, Edward V

“…We characterized cerebral folate deficiency (CFD) as any neuro-psychiatric condition associated with low spinal fluid (CSF) N5-methyltetrahydrofolate (MTHF)…”
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Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorders: Diagnosis, Treatment and Prevention by Bobrowski-Khoury, Natasha, Ramaekers, Vincent T., Sequeira, Jeffrey M., Quadros, Edward V.

“…Folate deficiency and folate receptor autoimmune disorder are major contributors to infertility, pregnancy related complications and abnormal fetal development…”
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Folate deficiency in rat pups during weaning causes learning and memory deficits by Berrocal-Zaragoza, Maria I., Sequeira, Jeffrey M., Murphy, Michelle M., Fernandez-Ballart, Joan D., Abdel Baki, Samah G., Bergold, Peter J., Quadros, Edward V.

“…Folate is essential for fetal development, and its deficiency during gestation causes behavioural deficits in the offspring. The present study investigated its…”
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Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin‐bound cobalamin by Jiang, Wenxia, Nakayama, Yasumi, Sequeira, Jeffrey M., Quadros, Edward V.

“…The membrane receptor TCblR/CD320 binds transcobalamin (TC) saturated with vitamin B12 [cobalamin (Cbl)] and mediates cellular uptake of the vitamin. The…”
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Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome by Ramaekers, Vincent T, Rothenberg, Sheldon P, Sequeira, Jeffrey M, Opladen, Thomas, Blau, Nenad, Quadros, Edward V, Selhub, Jacob

“…Childhood cerebral folate deficiency is a disabling neurologic disorder in which folate is reduced in the cerebrospinal fluid but not in the blood. The usual…”
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A milk‐free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome by Ramaekers, Vincent T, Sequeira, Jeffrey M, Blau, Nenad, Quadros, Edward V

“…In cerebral folate deficiency syndrome, the presence of autoantibodies against the folate receptor (FR) explains decreased folate transport to the central…”
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Advances in the understanding of cobalamin assimilation and metabolism by Quadros, Edward V.

“…Summary The haematological and neurological consequences of cobalamin deficiency define the essential role of this vitamin in key metabolic reactions. The…”
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The role of folate receptor autoantibodies in preterm birth by Vo, Hanh D., M.D, Sequeira, Jeffrey M., M.Sc, Quadros, Edward V., Ph.D, Schwarz, Steven M., M.D, Perenyi, Agnes R., M.D

“…Abstract Objective Cellular uptake of folate is mediated by folate receptor (FR)α. Prior studies indicate that a FRα autoantibody (FRAb) is implicated in poor…”
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Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B12 by Quadros, Edward V., Lai, Shao-Chiang, Nakayama, Yasumi, Sequeira, Jeffrey M., Hannibal, Luciana, Wang, Sihe, Jacobsen, Donald W., Fedosov, Sergey, Wright, Erica, Gallagher, Renata C., Anastasio, Natascia, Watkins, David, Rosenblatt, David S.

“…Elevated methylmalonic acid in five asymptomatic newborns whose fibroblasts showed decreased uptake of transcobalamin‐bound cobalamin (holo‐TC), suggested a…”
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Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse by Fernàndez-Roig, Sílvia, Lai, Shao-Chiang, Murphy, Michelle M, Fernandez-Ballart, Joan, Quadros, Edward V

“…DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are…”
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Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2 by Fine, Eugene J, Miller, Anna, Quadros, Edward V, Sequeira, Jeffrey M, Feinman, Richard D

“…Recent evidence suggests that several human cancers are capable of uncoupling of mitochondrial ATP generation in the presence of intact tricarboxylic acid…”
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Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects by Molloy, Anne M, Quadros, Edward V, Sequeira, Jeffrey M, Troendle, James F, Scott, John M, Kirke, Peadar N, Mills, James L

“…In this case–control study, which used stored blood samples to compare Irish women with a history of pregnancy complicated by neural-tube defect and women with…”
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