Risk factors for Pseudomonas aeruginosa infections in Asia-Pacific and consequences of inappropriate initial antimicrobial therapy: A systematic literature review and meta-analysis

•Asia-Pacific has high rates of antimicrobial resistance in Pseudomonas aeruginosa.•Initial appropriate antimicrobial therapy is associated with lower mortality than inappropriate therapy.•Risk factors for serious infection include previous exposure to antimicrobials.•Access to newer and appropriate...

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Bibliographic Details
Published in:	Journal of global antimicrobial resistance. Vol. 14; pp. 33 - 44
Main Authors:	Merchant, Sanjay, Proudfoot, Emma M., Quadri, Hafsa N., McElroy, Heather J., Wright, William R., Gupta, Ankur, Sarpong, Eric M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-09-2018
Subjects:	Asia-Pacific Inappropriate antimicrobial therapy Pseudomonas aeruginosa Risk factors Systematic literature review Asia-Pacific Pseudomonas aeruginosa Risk factors Inappropriate antimicrobial therapy Systematic literature review
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Summary:	•Asia-Pacific has high rates of antimicrobial resistance in Pseudomonas aeruginosa.•Initial appropriate antimicrobial therapy is associated with lower mortality than inappropriate therapy.•Risk factors for serious infection include previous exposure to antimicrobials.•Access to newer and appropriate antimicrobials is vital in the Asia-Pacific region. Treating infections of Gram-negative pathogens, in particular Pseudomonas aeruginosa, is a challenge for clinicians in the Asia-Pacific region owing to inherent and acquired antimicrobial resistance. This systematic review and meta-analysis provides updated information on risk factors for P. aeruginosa infection in Asia-Pacific as well as the consequences (e.g. mortality, costs) of initial inappropriate antimicrobial therapy (IIAT). Embase and MEDLINE databases were searched for Asia-Pacific studies reporting the consequences of IIAT versus initial appropriate antimicrobial therapy (IAAT) in Gram-negative bacterial infections as well as risk factors for serious P. aeruginosa infection. A meta-analysis of unadjusted mortality was performed using a random-effects model. A total of 22 studies reporting mortality and 13 reporting risk factors were identified. The meta-analysis demonstrated that mortality was significantly lower in patients receiving IAAT versus IIAT, with a 67% reduction observed for 28- or 30-day all-cause mortality (odds ratio=0.33, 95% confidence interval 0.20–0.55; P<0.001). Risk factors for serious P. aeruginosa infection include previous exposure to antimicrobials, mechanical ventilation and previous hospitalisation. High rates of antimicrobial resistance in Asia-Pacific as well as the increased mortality associated with IIAT and the presence of risk factors for serious infection highlight the importance of access to newer and appropriate antimicrobials.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	2213-7165 2213-7173
DOI:	10.1016/j.jgar.2018.02.005