Search Results - "Qu, Yusheng"

Proarrhythmia Risk Assessment in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Using the Maestro MEA Platform by Qu, Yusheng, Vargas, Hugo M

“…Evaluation of stem cell-derived cardiomyocytes (SC-CM) using multi-electrode array (MEA) has attracted attention as a novel model to detect drug-induced…”
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Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment by Zhou, Xin, Qu, Yusheng, Passini, Elisa, Bueno-Orovio, Alfonso, Liu, Yang, Vargas, Hugo M, Rodriguez, Blanca

“…Torsades de Pointes (TdP) is a type of ventricular arrhythmia which could be observed as an unwanted drug-induced cardiac side effect, and it is associated…”
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Comprehensive in vitro pro‐arrhythmic assays demonstrate that omecamtiv mecarbil has low pro‐arrhythmic risk by Qu, Yusheng, Gao, BaoXi, Arimura, Ziva, Fang, Mei, Vargas, Hugo M.

“…Omecamtiv mecarbil (OM) is a myosin activator (myotrope), developed as a potential therapeutic agent for heart failure with reduced ejection fraction. To…”
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Action Potential Recording and Pro-arrhythmia Risk Analysis in Human Ventricular Trabeculae by Qu, Yusheng, Page, Guy, Abi-Gerges, Najah, Miller, Paul E, Ghetti, Andre, Vargas, Hugo M

“…To assess drug-induced pro-arrhythmic risk, especially Torsades de Pointe (TdP), new models have been proposed, such as modeling of ventricular action…”
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AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties by Gavva, Narender R, Tamir, Rami, Qu, Yusheng, Klionsky, Lana, Zhang, T J, Immke, David, Wang, Judy, Zhu, Dawn, Vanderah, Todd W, Porreca, Frank, Doherty, Elizabeth M, Norman, Mark H, Wild, Kenneth D, Bannon, Anthony W, Louis, Jean-Claude, Treanor, James J S

“…The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel expressed by peripheral sensory neurons. TRPV1 antagonists produce…”
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Itraconazole decreases left ventricular contractility in isolated rabbit heart: Mechanism of action by Qu, Yusheng, Fang, Mei, Gao, BaoXi, Amouzadeh, Hamid R., Li, Nianyu, Narayanan, Padma, Acton, Paul, Lawrence, Jeff, Vargas, Hugo M.

“…Itraconazole (ITZ) is an approved antifungal agent that carries a “black box warning” in its label regarding a risk of negative cardiac inotropy based on…”
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BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart by Qu, Yusheng, Fang, Mei, Gao, Baoxi, Chui, Ray W, Vargas, Hugo M

“…Drug-induced cardiac arrhythmia, specifically Torsades de pointes, is associated with QT/QTc interval prolongation, thus prolongation of the QT interval is…”
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Oligomycin, a Complex V Inhibitor, Decreases Left Ventricular Contractility in Isolated Rabbit Heart by Fang, Mei, Qu, Yusheng, Gao, BaoXi, Acton, Paul, Hernandez, Rocio, Senal, Ihsan, Lawrence, Jeff, Vargas, Hugo M.

“…The isolated rabbit heart (IRH) model has been used to investigate the proarrhythmic potential of marketed drugs or drugs intended for market. In addition,…”
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Molecular Mechanism of Convergent Regulation of Brain Na + Channels by Protein Kinase C and Protein Kinase A Anchored to AKAP-15 by Cantrell, Angela R., Tibbs, Victoria C., Yu, Frank H., Murphy, Brian J., Sharp, Elizabeth M., Qu, Yusheng, Catterall, William A., Scheuer, Todd

“…Activation of D1-like dopamine (DA) receptors reduces peak Na + current in hippocampal neurons voltage-dependent in a manner via phosphorylation of the α…”
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Interaction of Batrachotoxin with the Local Anesthetic Receptor Site in Transmembrane Segment IVS6 of the Voltage-Gated Sodium Channel by Linford, Nancy J., Cantrell, Angela R., Qu, Yusheng, Scheuer, Todd, Catterall, William A.

“…The voltage-gated sodium channel is the site of action of more than six classes of neurotoxins and drugs that alter its function by interaction with distinct,…”
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Preclinical safety pharmacology risk assessment for oligonucleotides put into practice by Henderson, Kim, Engwall, Mike, Qu, Yusheng

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Modulation of Cardiac Na+ Channel Expression in Xenopus Oocytes by β1 Subunits (∗) by Qu, Yusheng, Isom, Lori L., Westenbroek, Ruth E., Rogers, John C., Tanada, Timothy N., McCormick, Kimberly A., Scheuer, Todd, Catterall, William A.

“…Voltage-gated Na+ channels consist of a large α subunit of 260 kDa associated with β1 and/or β2 subunits of 36 and 33 kDa, respectively. α subunits of rat…”
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Potent Blockade of Sodium Channels and Protection of Brain Tissue from Ischemia by BIII 890 CL by Carter, Adrian J., Grauert, Matthias, Pschorn, Uwe, Bechtel, Wolf Dietrich, Bartmann-Lindholm, Christina, Qu, Yusheng, Scheuer, Todd, Catterall, William A., Weiser, Thomas

“…We have synthesized a new benzomorphan derivative, 2R-[2α ,3(S*),6α…”
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Scientific Review of the Proarrhythmic Risks of Oligonucleotide Therapeutics: Are Dedicated ICH S7B/E14 Studies Needed for Low‐Risk Modalities? by Qu, Yusheng, Henderson, Kim A., Harper, Tod A., Vargas, Hugo M.

“…Oligonucleotide therapeutics (ONTs) represent a new modality with unique pharmacological and chemical properties that modulate gene expression with a high…”
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Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model by Gao, BaoXi, Sutherland, Weston, Vargas, Hugo M., Qu, Yusheng

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Simultaneous measurement of Ca-transient and contractility in isolated canine ventricular myocytes using IonOptix: Assay development and validation by Gao, BaoXi, Sutherland, Weston, Vargas, Hugo M., Qu, Yusheng

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Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions by Leishman, Derek J., Brimecombe, Jessica, Crumb, William, Hebeisen, Simon, Jenkinson, Steve, Kilfoil, Peter J., Matsukawa, Hiroshi, Melliti, Karim, Qu, Yusheng

“…Determination of a drug's potency in blocking the hERG channel is an established safety pharmacology study. Best practice guidelines have been published for…”
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Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective by Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J, Michael Foley, C., Gallacher, David, Greiter‐Wilke, Andrea, Guillon, Jean‐Michel, Guth, Brian, Himmel, Herbert M., Hegele‐Hartung, Christa, Ito, Maki, Jenkinson, Stephen, Chiba, Katsuyoshi, Lagrutta, Armando, Levesque, Paul, Martel, Eric, Okai, Yoshiko, Peri, Ravikumar, Pointon, Amy, Qu, Yusheng, Teisman, Ard, Traebert, Martin, Yoshinaga, Takashi, Gintant, Gary A., Leishman, Derek J., Valentin, Jean‐Pierre

“…Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes…”
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Modulation of Cardiac Na+Channels Expressed in a Mammalian Cell Line and in Ventricular Myocytes by Protein Kinase C by YUSHENG QU, ROGERS, J, TANADA, T, SCHEUER, T, CATTERALL, W. A

“…Cardiac rH1 Na+channel α subunits were expressed in cells of the Chinese hamster lung 1610 cell line by transfection, and a stable cell line expressing cardiac…”
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Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk by Qu, Yusheng, Gao, BaoXi, Arimura, Ziva, Fang, Mei, Vargas, Hugo M.

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