Search Results - "Qu, Wubin"

DELTA: A Distal Enhancer Locating Tool Based on AdaBoost Algorithm and Shape Features of Chromatin Modifications by Lu, Yiming, Qu, Wubin, Shan, Guangyu, Zhang, Chenggang

“…Accurate identification of DNA regulatory elements becomes an urgent need in the post-genomic era. Recent genome-wide chromatin states mapping efforts revealed…”
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A reliable and quick method for screening alternative splicing variants for low-abundance genes by Zhang, Yanchun, Qu, Wubin, Yan, Ruifen, Liu, Huqi, Zhang, Chenggang, Li, Zhihui, Dong, Guofu

“…Alternative splicing (AS) is a universal phenomenon in eukaryotes, and it is still challenging to identify AS events. Several methods have been developed to…”
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MFEprimer-3.0: quality control for PCR primers by Wang, Kun, Li, Haiwei, Xu, Yue, Shao, Qianzhi, Yi, Jianming, Wang, Ruichao, Cai, Wanshi, Hang, Xingyi, Zhang, Chenggang, Cai, Haoyang, Qu, Wubin

“…Quality control (QC) for lab-designed primers is crucial for the success of a polymerase chain reaction (PCR). Here, we present MFEprimer-3.0, a functional…”
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A Lasso regression model for the construction of microRNA-target regulatory networks by Lu, Yiming, Zhou, Yang, Qu, Wubin, Deng, Minghua, Zhang, Chenggang

“…MicroRNAs have recently emerged as a major class of regulatory molecules involved in a broad range of biological processes and complex diseases. Construction…”
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MPprimer: a program for reliable multiplex PCR primer design by Shen, Zhiyong, Qu, Wubin, Wang, Wen, Lu, Yiming, Wu, Yonghong, Li, Zhifeng, Hang, Xingyi, Wang, Xiaolei, Zhao, Dongsheng, Zhang, Chenggang

“…Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set…”
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MFEprimer-2.0: a fast thermodynamics-based program for checking PCR primer specificity by Qu, Wubin, Zhou, Yang, Zhang, Yanchun, Lu, Yiming, Wang, Xiaolei, Zhao, Dongsheng, Yang, Yi, Zhang, Chenggang

“…Evaluating the specificity of polymerase chain reaction (PCR) primers is an essential step in PCR primer design. The MFEprimer-2.0 server allows users to check…”
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MFEprimer: multiple factor evaluation of the specificity of PCR primers by Qu, Wubin, Shen, Zhiyong, Zhao, Dongsheng, Yang, Yi, Zhang, Chenggang

“…We developed a program named MFEprimer for evaluating the specificity of PCR primers based on multiple factors, including sequence similarity, stability at the…”
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Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array by Hang, Xingyi, Li, Peiyao, Li, Zhifeng, Qu, Wubin, Yu, Ying, Li, Hualing, Shen, Zhiyong, Zheng, Hao, Gao, Yan, Wu, Yonghong, Deng, Minghua, Sun, Zhixian, Zhang, Chenggang

“…The balance between endothelial cell survival and apoptosis during stress is an important cellular process for vessel integrity and vascular homeostasis, and…”
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Kmer-indexer: A Fast K-mer Indexing Program by Xiaolei, Wang, Wubin, Qu, Chenggang, Zhang, Dongsheng, Zhao

“…In our previous work, a k-mer based program named MFEprimer-2.0 was designed and developed for primer specificity evaluation task. In order to increase the…”
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Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens by Qu, Wubin, Ren, Changhong, Li, Yuan, Shi, Jinping, Zhang, Jiye, Wang, Xiaolei, Hang, Xingyi, Lu, Yiming, Zhao, Dongsheng, Zhang, Chenggang

“…The Ahringer C. elegans RNAi feeding library prepared by cloning genomic DNA fragments has been widely used in genome-wide analysis of gene function. However,…”
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VizPrimer: a web server for visualized PCR primer design based on known gene structure by Zhou, Yang, Qu, Wubin, Lu, Yiming, Zhang, Yanchun, Wang, Xiaolei, Zhao, Dongsheng, Yang, Yi, Zhang, Chenggang

“…The visualization of gene structure plays an important role in polymerase chain reaction (PCR) primer design, especially for eukaryotic genes with a number of…”
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REMAS: a new regression model to identify alternative splicing events from exon array data by Zheng, Hao, Hang, Xingyi, Zhu, Ji, Qian, Minping, Qu, Wubin, Zhang, Chenggang, Deng, Minghua

“…Alternative splicing (AS) is an important regulatory mechanism for gene expression and protein diversity in eukaryotes. Previous studies have demonstrated that…”
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Selecting specific PCR primers with MFEprimer by Qu, Wubin, Zhang, Chenggang

“…Selecting specific primers is crucial for polymerase chain reaction (PCR). Nonspecific primers will bind to unintended genes and result in nonspecific…”
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PCR Primer Design for the Rapidly Evolving SARS-CoV-2 Genome by Qu, Wubin, Li, Jiangyu, Cai, Haoyang, Zhao, Dongsheng

“…Real-time quantitative PCR is currently the most widely used method for the human pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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A MeSH-based text mining method for identifying novel prebiotics by Shan, Guangyu, Lu, Yiming, Min, Bo, Qu, Wubin, Zhang, Chenggang

“…Prebiotics contribute to the well-being of their host by altering the composition of the gut microbiota. Discovering new prebiotics is a challenging and…”
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sRNAPrimerDB: comprehensive primer design and search web service for small non-coding RNAs by Xie, Shengsong, Zhu, Qin, Qu, Wubin, Xu, Zhong, Liu, Xiangdong, Li, Xinyun, Li, Shijun, Ma, Wubin, Miao, Yiliang, Zhang, Lisheng, Du, Xiaoyong, Dong, Wuzi, Li, Haiwei, Zhao, Changzhi, Wang, Yunlong, Fang, Yaping, Zhao, Shuhong

“…Small non-coding RNAs (ncRNAs), especially microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs), play key roles in many biological processes. However, only a…”
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CRISPR-offinder: a CRISPR guide RNA design and off-target searching tool for user-defined protospacer adjacent motif by Zhao, Changzhi, Zheng, Xiaoguo, Qu, Wubin, Li, Guanglei, Li, Xinyun, Miao, Yi-Liang, Han, Xiaosong, Liu, Xiangdong, Li, Zhenhua, Ma, Yunlong, Shao, Qianzhi, Li, Haiwei, Sun, Fei, Xie, Shengsong, Zhao, Shuhong

“…Designing efficient and specific CRISPR single-guide RNAs (sgRNAs) is vital for the successful application of CRISPR technology. Currently, a growing number of…”
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Competitive Growth Enhances Conditional Growth Mutant Sensitivity to Antibiotics and Exposes a Two-Component System as an Emerging Antibacterial Target in Burkholderia cenocepacia by Gislason, April S, Choy, Matthew, Bloodworth, Ruhi A M, Qu, Wubin, Stietz, Maria S, Li, Xuan, Zhang, Chenggang, Cardona, Silvia T

“…Chemogenetic approaches to profile an antibiotic mode of action are based on detecting differential sensitivities of engineered bacterial strains in which the…”
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Genome-wide computational identification of bicistronic mRNA in humans by Lu, Yiming, Zhang, Yanchun, Hang, Xingyi, Qu, Wubin, Lubec, Gert, Chen, Changsheng, Zhang, Chenggang

“…Mammalian bicistronic mRNA is a recently discovered mammalian gene structure. Several reported cases of mammalian bicistronic mRNA indicated that genes of this…”
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Modelling epigenetic regulation of gene expression in 12 human cell types reveals combinatorial patterns of cell-type-specific genes by Lu, Yiming, Qu, Wubin, Min, Bo, Liu, Zheyan, Chen, Changsheng, Zhang, Chenggang

“…The maintenance of the diverse cell types in a multicellular organism is one of the fundamental mysteries of biology. Modelling the dynamic regulatory…”
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