Search Results - "Qu, Lingzhi"

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis by Wei, Hudie, Qu, Lingzhi, Dai, Shuyan, Li, Yun, Wang, Haolan, Feng, Yilu, Chen, Xiaojuan, Jiang, Longying, Guo, Ming, Li, Jun, Chen, Zhuchu, Chen, Lin, Zhang, Ye, Chen, Yongheng

“…The tumor suppressor p53 is mutated in approximately half of all human cancers. p53 can induce apoptosis through mitochondrial membrane permeabilization by…”
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Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor by Dai, Shuyan, Qu, Lingzhi, Li, Jun, Zhang, Ye, Jiang, Longying, Wei, Hudie, Guo, Ming, Chen, Xiaojuan, Chen, Yongheng

“…The aryl hydrocarbon receptor (AHR), a member of the basic helix–loop–helix (bHLH) Per–Arnt–Sim (PAS) family of transcription factors, plays important roles in…”
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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity by Wei, Hudie, Wang, Haolan, Wang, Genxin, Qu, Lingzhi, Jiang, Longying, Dai, Shuyan, Chen, Xiaojuan, Zhang, Ye, Chen, Zhuchu, Li, Youjun, Guo, Ming, Chen, Yongheng

“…Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein p53…”
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Quantum dots based molecular beacons for in vitro and in vivo detection of MMP-2 on tumor by Li, Xin, Deng, Dawei, Xue, Jianpeng, Qu, Lingzhi, Achilefu, Samuel, Gu, Yueqing

“…Matrix metalloproteinase-2 (MMP-2) is a protease related to tumor invasion and metastasis. It is heavily secreted by malignant tumor cells, allowing the…”
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Highly luminescent water-soluble quaternary Zn-Ag-In-S quantum dots for tumor cell-targeted imaging by Deng, Dawei, Cao, Jie, Qu, Lingzhi, Achilefu, Samuel, Gu, Yueqing

“…Exploring the synthesis and biomedical applications of biocompatible quantum dots (QDs) is currently one of the fastest growing fields of nanotechnology…”
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Quaternary Zn–Ag–In–Se Quantum Dots for Biomedical Optical Imaging of RGD-Modified Micelles by Deng, Dawei, Qu, Lingzhi, Zhang, Jian, Ma, Yuxiang, Gu, Yueqing

“…Exploring the synthesis of new biocompatible quantum dots (QDs) helps in overcoming the intrinsic toxicity of the existing QDs composed of highly toxic heavy…”
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LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance by Wu, Daichao, Guo, Ming, Min, Xiaoli, Dai, Shuyan, Li, Meixiang, Tan, Sijie, Li, Guoqing, Chen, Xiaojuan, Ma, Yao, Li, Jun, Jiang, Longying, Qu, Lingzhi, Zhou, Zhan, Chen, Zhuchu, Chen, Lin, Xu, Guangyu, Chen, Yongheng

“…The chemical compound LY2874455 has the potential to overcome drug resistance driven by FGFR gatekeeper mutations. X-ray crystallographic studies provide the…”
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Comprehensive analysis of necroptosis-related lncRNA signature with potential implications in tumor heterogeneity and prediction of prognosis in clear cell renal cell carcinoma by Lin, Hang, Qu, Lingzhi, Chen, Guanqiu, Zhang, Chunfang, Lu, Liqing, Chen, Yongheng

“…Necroptosis has been reported to play a critical role in occurrence and progression of cancer. The dysregulation of long non-coding RNAs (lncRNAs) is…”
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Simulation Study on Axial Location Identification of Damage in Layered Pipeline Structures Based on Damage Index by Li, Ying, Qu, Lingzhi, Qi, Baoxin

“…This study investigates the feasibility of identifying the axial position of circumferential defects in laminated pipeline structures based on damage indices…”
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IMF: Interpretable Multi-Hop Forecasting on Temporal Knowledge Graphs by Du, Zhenyu, Qu, Lingzhi, Liang, Zongwei, Huang, Keju, Cui, Lin, Gao, Zhiyang

“…Temporal knowledge graphs (KGs) have recently attracted increasing attention. The temporal KG forecasting task, which plays a crucial role in such applications…”
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Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site by Li, Jun, Dantas Machado, Ana Carolina, Guo, Ming, Sagendorf, Jared M, Zhou, Zhan, Jiang, Longying, Chen, Xiaojuan, Wu, Daichao, Qu, Lingzhi, Chen, Zhuchu, Chen, Lin, Rohs, Remo, Chen, Yongheng

“…FOXA2, a member of the forkhead family of transcription factors, plays essential roles in liver development and bile acid homeostasis. In this study, we report…”
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Specific emitter identification based on one-dimensional complex-valued residual networks with an attention mechanism by Qu, Lingzhi, Yang, Junan, Huang, Keju, Liu, Hui

“…Specific emitter identification (SEI) can distinguish single-radio transmitters using the subtle features of the received waveform. Therefore, it is used…”
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Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455 by Wu, Daichao, Guo, Ming, Philips, Michael A, Qu, Lingzhi, Jiang, Longying, Li, Jun, Chen, Xiaojuan, Chen, Zhuchu, Chen, Lin, Chen, Yongheng

“…Aberrant FGFR4 signaling has been documented abundantly in various human cancers. The majority of FGFR inhibitors display significantly reduced potency toward…”
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Structure-based design of a dual-warhead covalent inhibitor of FGFR4 by Chen, Xiaojuan, Li, Huiliang, Lin, Qianmeng, Dai, Shuyan, Yue, Sitong, Qu, Lingzhi, Li, Maoyu, Guo, Ming, Wei, Hudie, Li, Jun, Jiang, Longying, Xu, Guangyu, Chen, Yongheng

“…The fibroblast growth factor 19 (FGF19)/fibroblast growth factor receptor 4 (FGFR4) signaling pathways play critical roles in a variety of cancers, such as…”
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Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants by Lin, Qianmeng, Chen, Xiaojuan, Qu, Lingzhi, Guo, Ming, Wei, Hudie, Dai, Shuyan, Jiang, Longying, Chen, Yongheng

“…Fibroblast growth factor receptor (FGFR) dysregulation is involved in a variety of tumorigenesis and development. Cholangiocarcinoma is closely related with…”
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Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors by Qu, Lingzhi, Chen, Xiaojuan, Wei, Hudie, Guo, Ming, Dai, Shuyan, Jiang, Longying, Li, Jun, Yue, Sitong, Chen, Zhuchu, Chen, Yongheng

“…FIIN-2, TAS-120 (Futibatinib) and PRN1371 are highly potent pan-FGFR covalent inhibitors targeting the p-loop cysteine of FGFR proteins, of which TAS-120 and…”
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Versatile Self-Assembly of Water-Soluble Thiol-Capped CdTe Quantum Dots: External Destabilization and Internal Stability of Colloidal QDs by Deng, Dawei, Qu, Lingzhi, Li, Yang, Gu, Yueqing

“…In this paper, we report on the versatile self-assembly of water-soluble thiol-capped CdTe quantum dots (QDs), nanoparticles (NPs), or nanocrystals induced by…”
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Highly luminescent water-soluble quaternary Zn–Ag–In–S quantum dots and their unique precursor S/In ratio-dependent spectral shifts by Deng, Dawei, Qu, Lingzhi, Cheng, Zhiqiang, Achilefu, Samuel, Gu, Yueqing

“…Quaternary I–II–III–VI semiconductor quantum dots (QDs) containing less toxic elements are receiving increasing attention because of their promising…”
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Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R by Lin, Qianmeng, Dai, Shuyan, Qu, Lingzhi, Lin, Hang, Guo, Ming, Wei, Hudie, Chen, Yongheng, Chen, Xiaojuan

“…Acquired drug resistance poses a challenge for single-target FGFR inhibitors, leading to the development of dual- or multi-target FGFR inhibitors. Sulfatinib…”
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Forming highly fluorescent near-infrared emitting PbS quantum dots in water using glutathione as surface-modifying molecule by Deng, Dawei, Xia, Junfei, Cao, Jie, Qu, Lingzhi, Tian, Junmei, Qian, Zhiyu, Gu, Yueqing, Gu, Zhongze

“…[Display omitted] ► We developed a new facile method for transferring oil-soluble PbS QDs into water with glutathione. ► The resulting water-soluble GSH-capped…”
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