Search Results - "Qu, Huinan"

CLDN6: From Traditional Barrier Function to Emerging Roles in Cancers by Qu, Huinan, Jin, Qiu, Quan, Chengshi

“…Claudins (CLDNs) are the most important tight junction proteins, which are mainly expressed in endothelial cells or epithelial cells in a tissue-specific…”
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New insights into the regulation of METTL3 and its role in tumors by Jin, Qiu, Qu, Huinan, Quan, Chengshi

“…As one of the most abundant epigenetic modifications in RNA, N -methyladenosine (m A) affects RNA transcription, splicing, stability, and posttranscriptional…”
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Estrogen receptor β inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy by Song, Peiye, Li, Yanru, Dong, Yuan, Liang, Yingying, Qu, Huinan, Qi, Da, Lu, Yan, Jin, Xiangshu, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Xu, Wenhong, Quan, Chengshi

“…Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not…”
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CLDN5: From structure and regulation to roles in tumors and other diseases beyond CNS disorders by Ling, Yao, Kang, Xinxin, Yi, Ying, Feng, Shenao, Ma, Guanshen, Qu, Huinan

“…Claudin-5 (CLDN5) is an essential component of tight junctions (TJs) and is critical for the integrity of the blood-brain barrier (BBB), ensuring homeostasis…”
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CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation by Jin, Qiu, Qi, Da, Zhang, Mingzi, Qu, Huinan, Dong, Yuan, Sun, Minghao, Quan, Chengshi

“…Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide, with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor…”
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CLDN6 inhibits breast cancer metastasis through WIP-dependent actin cytoskeleton-mediated autophagy by Dong, Yuan, Jin, Qiu, Sun, Minghao, Qi, Da, Qu, Huinan, Wang, Xinqi, Quan, Chengshi

“…As a breast cancer suppressor gene, CLDN6 overexpression was found to inhibit breast cancer metastasis in our previous studies, but the specific mechanism…”
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CLDN6 Suppresses c-MYC-Mediated Aerobic Glycolysis to Inhibit Proliferation by TAZ in Breast Cancer by Qu, Huinan, Qi, Da, Wang, Xinqi, Dong, Yuan, Jin, Qiu, Wei, Junyuan, Quan, Chengshi

“…Claudin 6 (CLDN6) was found to be a breast cancer suppressor gene, which is lowly expressed in breast cancer and inhibits breast cancer cell proliferation upon…”
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A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis by Jia, Yiyang, Guo, Yantong, Jin, Qiu, Qu, Huinan, Qi, Da, Song, Peiye, Zhang, Xiaoli, Wang, Xinqi, Xu, Wenhong, Dong, Yuan, Liang, Yingying, Quan, Chengshi

“…We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly…”
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OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases by Lu, Yan, Qu, Huinan, Qi, Da, Xu, Wenhong, Liu, Shutong, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Li, Hairi, Li, Yulin, Quan, Chengshi

“…Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by…”
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Independent prognostic value of CLDN6 in bladder cancer based on M2 macrophages related signature by Qi, Da, Lu, Yan, Qu, Huinan, Dong, Yuan, Jin, Qiu, Sun, Minghao, Li, Yanru, Quan, Chengshi

“…M2 macrophages are associated with the prognosis of bladder cancer. CLDN6 has been linked to immune infiltration and is crucial for predicting the prognosis in…”
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CLDN6 promotes chemoresistance through GSTP1 in human breast cancer by Yang, Minlan, Li, Yanru, Shen, Xiangfeng, Ruan, Yang, Lu, Yan, Jin, Xiangshu, Song, Peiye, Guo, Yantong, Zhang, Xiaoli, Qu, Huinan, Shao, Yijia, Quan, Chengshi

“…Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer…”
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The expression and the tumor suppressor role of CLDN6 in colon cancer by Qu, Huinan, Wang, Min, Wang, Miaomiao, Liu, Yuanyuan, Quan, Chengshi

“…As a member of the tight junction family, CLDN6 is a tumor suppressor in breast cancer, but its role in colon cancer is unknown. In this research, we aimed at…”
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CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis by Dong, Yuan, Xu, Wenhong, Qi, Da, Qu, Huinan, Jin, Qiu, Sun, Minghao, Wang, Xudong, Quan, Chengshi

“…Colorectal cancer (CRC) is one of the most common cancers in the world. Abnormal proliferation is a chief characteristic of cancer and is the initiation of CRC…”
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CLDN6 inhibits breast cancer cell malignant behavior by suppressing ERK signaling by Lu, Yan, Shao, Yijia, Xie, Yinping, Qu, Huinan, Qi, Da, Dong, Yuan, Jin, Qiu, Wang, Liping, Wei, Junyuan, Quan, Chengshi

“…Claudin 6 (CLDN6) is an important component of tight junctions. Through the PDZ binding motif, CLDN6 binds to a variety of signaling proteins that contain the…”
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ERα is required for suppressing OCT4‐induced proliferation of breast cancer cells via DNMT1/ISL1/ERK axis by Jin, Xiangshu, Li, Yanru, Guo, Yantong, Jia, Yiyang, Qu, Huinan, Lu, Yan, Song, Peiye, Zhang, Xiaoli, Shao, Yijia, Qi, Da, Xu, Wenhong, Quan, Chengshi

“…Objective POU5F1 (OCT4) is implicated in cancer stem cell self‐renewal. Currently, some studies have shown that OCT4 has a dual function in suppressing or…”
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A SUMOylation-dependent HIF-1[alpha]/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis by Jia, Yiyang, Guo, Yantong, Jin, Qiu, Qu, Huinan, Qi, Da, Song, Peiye, Zhang, Xiaoli, Wang, Xinqi, Xu, Wenhong, Dong, Yuan, Liang, Yingying, Quan, Chengshi

“…Background We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a…”
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Estrogen receptor [beta] inhibits breast cancer cells migration and invasion through CLDN6-mediated autophagy by Song, Peiye, Li, Yanru, Dong, Yuan, Liang, Yingying, Qu, Huinan, Qi, Da, Lu, Yan, Jin, Xiangshu, Guo, Yantong, Jia, Yiyang, Wang, Xinqi, Xu, Wenhong, Quan, Chengshi

“…Background Estrogen receptor [beta] (ER[beta]) has been reported to play an anti-cancer role in breast cancer, but the regulatory mechanism by which ER[beta]…”
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