Expression of transient receptor potential melastatin 4 in differential diagnosis of eosinophilic renal tumors

Expression of transient receptor potential melastatin 4 in differential diagnosis of eosinophilic renal tumors

Immunohistochemical and molecular studies to differentiate eosinophilic kidney tumors are gradually increasing. The present study investigated the role of transient receptor potential cation channel subfamily M member 4 (TRPM4), a non-selective cation channel associated with migration, proliferation...

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Bibliographic Details
Published in:Molecular and clinical oncology Vol. 15; no. 5
Main Authors: Qoban, Ganime, Yildiz, Pelin, Dogan, Bayram, Sahin, Nurhan, Gucin, Zuhal
Format: Journal Article
Language:English
Published: Athens Spandidos Publications 01-11-2021
Spandidos Publications UK Ltd
D.A. Spandidos
Subjects:
Apoptosis
Cancer
Cervical cancer
Immunohistochemistry
Kidney cancer
Lymphoma
Medical diagnosis
Medical research
Medicine, Experimental
Morphology
Oncology
Patients
Prostate
Statistical analysis
Tumors
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Summary:Immunohistochemical and molecular studies to differentiate eosinophilic kidney tumors are gradually increasing. The present study investigated the role of transient receptor potential cation channel subfamily M member 4 (TRPM4), a non-selective cation channel associated with migration, proliferation and invasion in cancer cells, in this differentiation. The aim was to investigate the effectiveness of TRPM4 in differentiation of eosinophilic kidney tumors. The study included a total of 112 patients, including 97 eosinophilic kidney tumors with the diagnoses of 33 eosinophilic clear cell renal cell carcinoma (CCRCC), 35 eosinophilic chromophobe renal cell carcinoma (ChRCC), 8 papillary renal cell carcinoma type 2 (P2RCC), 21 renal oncocytoma (RO), as well as 15 papillary renal cell carcinoma type 1 to differentiate from P2RCC. For TRPM4, diffuse staining (>10%) was observed in 2 CCRCC, 15 ChRCC, 20 RO and 4 P2RCC cases. There was a significant difference between eosinophilic CCRCC and other eosinophilic tumors (P<0.05). While basolateral staining was observed in papillary tumors, membrane staining was observed in other stained cases. It was hypothesized that the use of TRPM4 along with morphological findings, cytokeratin 7 and other markers may be useful for the differentiation of eosinophilic kidney tumors.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2021.2393