Search Results - "Qiu, Yuran"

Computational methods-guided design of modulators targeting protein-protein interactions (PPIs) by Qiu, Yuran, Li, Xinyi, He, Xinheng, Pu, Jun, Zhang, Jian, Lu, Shaoyong

“…Protein-protein interactions (PPIs) play a pivotal role in extensive biological processes and are thus crucial to human health and the development of disease…”
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Untangling Dual-Targeting Therapeutic Mechanism of Epidermal Growth Factor Receptor (EGFR) Based on Reversed Allosteric Communication by Qiu, Yuran, Yin, Xiaolan, Li, Xinyi, Wang, Yuanhao, Fu, Qiang, Huang, Renhua, Lu, Shaoyong

“…Dual-targeting therapeutics by coadministration of allosteric and orthosteric drugs is drawing increased attention as a revolutionary strategy for overcoming…”
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Conformational Selection Mechanism Provides Structural Insights into the Optimization of APC-Asef Inhibitors by He, Xinheng, Huang, Ning, Qiu, Yuran, Zhang, Jian, Liu, Yaqin, Yin, Xiao-Lan, Lu, Shaoyong

“…Metastasis is the major cause of death in colorectal cancer and it has been proven that inhibiting an interaction between adenomatous polyposis coli (APC) and…”
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Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins by Wang, Yuanhao, Ji, Dong, Lei, Chaoyu, Chen, Yingfei, Qiu, Yuran, Li, Xinyi, Li, Mingyu, Ni, Duan, Pu, Jun, Zhang, Jian, Fu, Qiang, Liu, Yaqin, Lu, Shaoyong

“…[Display omitted] Ras undergoes interconversion between the active GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the…”
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Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells by Zhang, Qiufen, Chen, Yingyi, Ni, Duan, Huang, Zhimin, Wei, Jiacheng, Feng, Li, Su, Jun-Cheng, Wei, Yingqing, Ning, Shaobo, Yang, Xiuyan, Zhao, Mingzhu, Qiu, Yuran, Song, Kun, Yu, Zhengtian, Xu, Jianrong, Li, Xinyi, Lin, Houwen, Lu, Shaoyong, Zhang, Jian

“…SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by…”
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Targeting RAS phosphorylation in cancer therapy: Mechanisms and modulators by Qiu, Yuran, Wang, Yuanhao, Chai, Zongtao, Ni, Duan, Li, Xinyi, Pu, Jun, Chen, Jie, Zhang, Jian, Lu, Shaoyong, Lv, Chuan, Ji, Mingfei

“…RAS, a member of the small GTPase family, functions as a binary switch by shifting between inactive GDP-loaded and active GTP-loaded state. RAS…”
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Cardiovascular toxicity of tyrosine kinase inhibitors during cancer treatment: Potential involvement of TRPM7 by Liu, Qing, Li, Suyao, Qiu, Yuran, Zhang, Jiayu, Rios, Francisco J, Zou, Zhiguo, Touyz, Rhian M

“…Receptor tyrosine kinases (RTKs) are a class of membrane spanning cell-surface receptors that transmit extracellular signals through the membrane to trigger…”
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Using machine learning models to identify the risk of depression in middle-aged and older adults with frequent and infrequent nicotine use: A cross-sectional study by Qiu, Yuran, Ma, Xu

“…Depression is very prevalent in middle-aged and older smokers. Therefore, we aimed to identify the risk of depression among middle-aged and older adults with…”
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Combining Allosteric and Orthosteric Drugs to Overcome Drug Resistance by Ni, Duan, Li, Yun, Qiu, Yuran, Pu, Jun, Lu, Shaoyong, Zhang, Jian

“…Historically, most drugs target protein orthosteric sites. The gradual emergence of resistance hampers their therapeutic effectiveness, posing a challenge to…”
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Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery by Lu, Shaoyong, Qiu, Yuran, Ni, Duan, He, Xinheng, Pu, Jun, Zhang, Jian

“…•Allosteric drug discovery is gaining increasing attention.•Allosteric drug-resistance mutations hamper the application of allosteric drugs.•We review the…”
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Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy by Ni, Duan, Wei, Jiacheng, He, Xinheng, Rehman, Ashfaq Ur, Li, Xinyi, Qiu, Yuran, Pu, Jun, Lu, Shaoyong, Zhang, Jian

“…Allostery, which is one of the most direct and efficient methods to fine-tune protein functions, has gained increasing recognition in drug discovery. However,…”
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