Search Results - "Qiu, Dinghong"

A NRF2 inhibitor selectively sensitizes KEAP1 mutant tumor cells to cisplatin and gefitinib by restoring NRF2-inhibitory function of KEAP1 mutants by Aboulkassim, Tahar, Tian, Xiaohong, Liu, Qiang, Qiu, Dinghong, Hancock, Mark, Wu, Jian Hui, Batist, Gerald

“…NRF2 (nuclear factor erythroid 2-related factor 2) is a master regulator of protective responses in healthy tissues. However, when it is active in tumor cells,…”
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Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype by Bai, Xiuying, Dinghong, Qiu, Miao, Dengshun, Goltzman, David, Karaplis, Andrew C

“…Transgenic mice overexpressing fibroblast growth factor (FGF23) (R176Q) (F(Tg)) exhibit biochemical {hypophosphatemia, phosphaturia, abnormal…”
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SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal domain by Yi, Qianhui, Han, Xiaojun, Yu, Henry G., Chen, Huei-Yu, Qiu, Dinghong, Su, Jie, Lin, Rongtuan, Batist, Gerald, Wu, Jian Hui

“…Androgen deprivation therapies (ADT) are the mainstay treatments for castration-resistant prostate cancer (CRPC). ADT suppresses the androgen receptor (AR)…”
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A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy by Chang, Chia-Hao, Bijian, Krikor, Wernic, Dominik, Su, Jie, da Silva, Sabrina Daniela, Yu, Henry, Qiu, Dinghong, Asslan, Mariana, Alaoui-Jamali, Moulay A.

“…Patients with triple-negative breast cancer (TNBC) often have a poor prognosis largely due to lack of effective targeted therapy. Using a library of…”
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CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders by Bai, Xiuying, Miao, Dengshun, Xiao, Sophia, Qiu, Dinghong, St-Arnaud, René, Petkovich, Martin, Gupta, Ajay, Goltzman, David, Karaplis, Andrew C

“…CYP24A1 (hereafter referred to as CYP24) enzymatic activity is pivotal in the inactivation of vitamin D metabolites. Basal renal and extrarenal CYP24 is…”
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Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2 by Saad, Amine, Bijian, Krikor, Qiu, Dinghong, da Silva, Sabrina Daniela, Marques, Maud, Chang, Chia-Hao, Nassour, Hassan, Ramotar, Dindial, Damaraju, Sambasivarao, Mackey, John, Bismar, Tarek, Witcher, Michael, Alaoui-Jamali, Moulay A.

“…Fascin 1 (FSCN1) is a cytoskeleton-associated protein recognized to function primarily in the regulation of cytoskeleton structure and formation of plasma…”
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Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells by Chang, Chia-Hao, Bijian, Krikor, Qiu, Dinghong, Su, Jie, Saad, Amine, Dahabieh, Michael S, Miller, Jr, Wilson H, Alaoui-Jamali, Moulay A

“…Post-translational mechanisms regulating cell-matrix adhesion turnover during cell locomotion are not fully elucidated. In this study, we uncovered an…”
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