Search Results - "Qin, Xiao F."

Inference of immune cell composition on the expression profiles of mouse tissue by Chen, Ziyi, Huang, Anfei, Sun, Jiya, Jiang, Taijiao, Qin, F. Xiao-Feng, Wu, Aiping

“…Mice are some of the widely used experimental animal models for studying human diseases. Defining the compositions of immune cell populations in various…”
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model by Li, Chunfeng, Deng, Yong-Qiang, Wang, Shuo, Ma, Feng, Aliyari, Roghiyh, Huang, Xing-Yao, Zhang, Na-Na, Watanabe, Momoko, Dong, Hao-Long, Liu, Ping, Li, Xiao-Feng, Ye, Qing, Tian, Min, Hong, Shuai, Fan, Junwan, Zhao, Hui, Li, Lili, Vishlaghi, Neda, Buth, Jessie E., Au, Connie, Liu, Ying, Lu, Ning, Du, Peishuang, Qin, F. Xiao-Feng, Zhang, Bo, Gong, Danyang, Dai, Xinghong, Sun, Ren, Novitch, Bennett G., Xu, Zhiheng, Qin, Cheng-Feng, Cheng, Genhong

“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
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Evolving roles of CD38 metabolism in solid tumour microenvironment by Gao, Long, Du, Xiaohong, Li, Jiabin, Qin, F. Xiao-Feng

“…Given that plenty of clinical findings and reviews have already explained in detail on the progression of CD38 in multiple myeloma and haematological system…”
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SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction by Wang, Fei, Nguyen, Margaret, Qin, F. Xiao‐Feng, Tong, Qiang

“…Summary The sirtuin family of nicotinamide adenine dinucleotide‐dependant (NAD) deacetylases plays an important role in aging and metabolic regulation. In…”
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Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells by Liu, Yuying, Liang, Xiaoyu, Yin, Xiaonan, Lv, Jiadi, Tang, Ke, Ma, Jingwei, Ji, Tiantian, Zhang, Huafeng, Dong, Wenqian, Jin, Xun, Chen, Degao, Li, Yanchun, Zhang, Songyan, Xie, Heidi Q., Zhao, Bin, Zhao, Tong, Lu, Jinzhi, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F. Xiao-Feng, Huang, Bo

“…Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D…”
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Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression by Chen, Limo, Gibbons, Don L., Goswami, Sangeeta, Cortez, Maria Angelica, Ahn, Young-Ho, Byers, Lauren A., Zhang, Xuejun, Yi, Xiaohui, Dwyer, David, Lin, Wei, Diao, Lixia, Wang, Jing, Roybal, Jonathon D., Patel, Mayuri, Ungewiss, Christin, Peng, David, Antonia, Scott, Mediavilla-Varela, Melanie, Robertson, Gordon, Jones, Steve, Suraokar, Milind, Welsh, James W., Erez, Baruch, Wistuba, Ignacio I., Chen, Lieping, Peng, Di, Wang, Shanshan, Ullrich, Stephen E., Heymach, John V., Kurie, Jonathan M., Qin, F. Xiao-Feng

“…Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We…”
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Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities by Du, Xiaohong, Zuo, Xiangyang, Meng, Fang, Wu, Fei, Zhao, Xin, Li, Chunfeng, Cheng, Genhong, Qin, F. Xiao-Feng

“…Ebola virus (EBOV), pathogen of Ebola hemorrhagic fever (EHF), is an enveloped filamental RNA virus. Recently, the EHF crisis occurred in the Democratic…”
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Omicron adopts a different strategy from Delta and other variants to adapt to host by Du, Xiaohong, Tang, Haijun, Gao, Long, Wu, Zhao, Meng, Fang, Yan, Ruhong, Qiao, Shigang, An, Jianzhong, Wang, Chen, Qin, F. Xiao-Feng

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Two Functional Subsets of FOXP3 + Regulatory T Cells in Human Thymus and Periphery by Ito, Tomoki, Hanabuchi, Shino, Wang, Yi-Hong, Park, Woong Ryeon, Arima, Kazuhiko, Bover, Laura, Qin, F. Xiao-Feng, Gilliet, Michel, Liu, Yong-Jun

“…Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and…”
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Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation by Tan, Guangyun, Yi, Zhaohong, Song, Hongxiao, Xu, Fengchao, Li, Feng, Aliyari, Roghiyh, Zhang, Hong, Du, Peishuang, Ding, Yanhua, Niu, Junqi, Wang, Xiaosong, Su, Lishan, Qin, F. Xiao-Feng, Cheng, Genhong

“…To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular…”
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TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein by Wang, Shanshan, Chen, Yongzhi, Li, Chunfeng, Wu, Yaoxing, Guo, Lei, Peng, Changwei, Huang, Yueping, Cheng, Genhong, Qin, F. Xiao-Feng

“…Tripartite motif 14 (TRIM14) was reported to function as a mitochondrial signaling adaptor in mediating innate immune responses. However, the involvement of…”
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Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance by Li, Yaqi, Liu, Jing, Gao, Long, Liu, Yuan, Meng, Fang, Li, Xiaoan, Qin, F. Xiao-Feng

“…•Immunotherapy induces long lasting immune responses in cancer patients.•Immune checkpoint therapy with traditional treatment produces promising…”
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seq-ImmuCC: Cell-Centric View of Tissue Transcriptome Measuring Cellular Compositions of Immune Microenvironment From Mouse RNA-Seq Data by Chen, Ziyi, Quan, Lijun, Huang, Anfei, Zhao, Qiang, Yuan, Yao, Yuan, Xuye, Shen, Qin, Shang, Jingzhe, Ben, Yinyin, Qin, F Xiao-Feng, Wu, Aiping

“…The RNA sequencing approach has been broadly used to provide gene-, pathway-, and network-centric analyses for various cell and tissue samples. However, thus…”
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Tissue-specific deconvolution of immune cell composition by integrating bulk and single-cell transcriptomes by Chen, Ziyi, Ji, Chengyang, Shen, Qin, Liu, Wei, Qin, F Xiao-Feng, Wu, Aiping

“…Abstract Motivation Many methods have been developed to estimate immune cell composition from tissue transcriptomes. One common characteristic of these methods…”
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cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis by Zhang, Yiyue, Jin, Hao, Li, Li, Qin, F. Xiao-Feng, Wen, Zilong

“…The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking…”
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A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation by Peng, Di, Wang, Zining, Huang, Anfei, Zhao, Yong, Qin, F Xiao-Feng

“…The F-box proteins were originally identified as the key component of SKP1-Cullin1-F-box E3 ligase complexes that control the stability of their specific…”
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Interferon-Inducible Cholesterol-25-Hydroxylase Inhibits Hepatitis C Virus Replication via Distinct Mechanisms by Chen, Yongzhi, Wang, Shanshan, Yi, Zhaohong, Tian, Huabin, Aliyari, Roghiyh, Li, Yanhua, Chen, Gang, Liu, Ping, Zhong, Jin, Chen, Xinwen, Du, Peishuang, Su, Lishan, Qin, F. Xiao-Feng, Deng, Hongyu, Cheng, Genhong

“…Cholesterol 25-hydroxylase (CH25H) as an interferon-stimulated gene (ISG) has recently been shown to exert broad antiviral activity through the production of…”
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Inhibition of Influenza A Virus Replication by TRIM14 via Its Multifaceted Protein-Protein Interaction With NP by Wu, Xiangwei, Wang, Jingfeng, Wang, Shanshan, Wu, Fei, Chen, Zhigao, Li, Chunfeng, Cheng, Genhong, Qin, F Xiao-Feng

“…Influenza A virus (IAV) is a worldwide ongoing health threat causing diseases in both humans and animals. The interaction between IAV and host is a dynamic and…”
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STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells by Liu, Yuying, Lv, Jiadi, Liu, Jinyan, Liang, Xiaoyu, Jin, Xun, Xie, Jing, Zhang, Le, Chen, Degao, Fiskesund, Roland, Tang, Ke, Ma, Jingwei, Zhang, Huafeng, Dong, Wenqian, Mo, Siqi, Zhang, Tianzhen, Cheng, Feiran, Zhou, Yabo, Jia, Qingzhu, Zhu, Bo, Kong, Yan, Guo, Jun, Zhang, Haizeng, Hu, Zhuo-Wei, Cao, Xuetao, Qin, F Xiao-Feng, Huang, Bo

“…Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer…”
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Identification of TRIM14 as a Type I IFN-Stimulated Gene Controlling Hepatitis B Virus Replication by Targeting HBx by Tan, Guangyun, Xu, Fengchao, Song, Hongxiao, Yuan, Ye, Xiao, Qingfei, Ma, Feng, Qin, F Xiao-Feng, Cheng, Genhong

“…Hepatitis B virus (HBV) remains a major cause of hepatic disease that threatens human health worldwide. Type I IFN (IFN-I) therapy is an important therapeutic…”
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