Search Results - "Qin, Shuanglin"

A Diboronic Acid-Based Fluorescent Sensor Array for Rapid Identification of Lonicerae Japonicae Flos and Lonicerae Flos by Bian, Ying, Xiang, Chenqing, Xu, Yi, Zhu, Rongping, Qin, Shuanglin, Zhang, Zhijun

“…Lonicerae japonicae flos (LJF) and Lonicerae flos (LF) are traditional Chinese herbs that are commonly used and widely known for their medicinal properties and…”
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Exploring the mechanism of 6-Methoxydihydrosanguinarine in the treatment of lung adenocarcinoma based on network pharmacology, molecular docking and experimental investigation by Liu, Xingyun, Ren, Yanling, Qin, Shuanglin, Yang, Zerui

“…6-Methoxydihydrosanguinarine (6-MDS) has shown promising potential in fighting against a variety of malignancies. Yet, its anti‑lung adenocarcinoma (LUAD)…”
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Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development by Xu, Mengwei, Bai, Zhaofang, Xie, Baocheng, Peng, Rui, Du, Ziwei, Liu, Yan, Zhang, Guangshuai, Yan, Si, Xiao, Xiaohe, Qin, Shuanglin

“…Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the…”
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Insights on Antitumor Activity and Mechanism of Natural Benzophenanthridine Alkaloids by Peng, Rui, Xu, Mengwei, Xie, Baocheng, Min, Qing, Hui, Siwen, Du, Ziwei, Liu, Yan, Yu, Wei, Wang, Shi, Chen, Xin, Yang, Guang, Bai, Zhaofang, Xiao, Xiaohe, Qin, Shuanglin

“…Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely found in the plants of papaveraceae, corydalis, and rutaceae. Biological…”
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Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production by Wen, Jincai, Mu, Wenqing, Li, Hui, Yan, Yulu, Zhan, Xiaoyan, Luo, Wei, Wang, Zhongxia, Kan, Wen, Zhao, Jia, Hui, Siwen, He, Ping, Qin, Shuanglin, Xu, Yingjie, Zhang, Ping, Xiao, Xiaohe, Xu, Guang, Bai, Zhaofang

“…The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong…”
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Glycyrrhiza uralensis polysaccharides ameliorates cecal ligation and puncture-induced sepsis by inhibiting the cGAS-STING signaling pathway by Hui, Siwen, Kan, Wen, Qin, Shuanglin, He, Ping, Zhao, Jia, Li, Hui, Bai, Jun, Wen, Jincai, Mou, Wenqing, Hou, Manting, Wei, Ziying, Lin, Li, Xiao, Xiaohe, Xu, Guang, Bai, Zhaofang

“…( ) is an ancient and widely used traditional Chinese medicine with good efficacy in clearing heat and detoxifying action. Studies suggest that Polysaccharides…”
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Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids by Liu, Xinhua, Li, Benlong, Zhang, Zhen, Wei, Yujiao, Xu, Zhongxin, Qin, Shuanglin, Liu, Ning, Zhao, Rui, Peng, Junya, Yang, Guang, Qi, Min, Liu, Tongtong, Xie, Maodun, Liu, Shuangwei, Gao, Xian, Lu, Cheng, Zhu, Lijun, Long, Xinyu, Kang, Hong, Sun, Tao, Zhou, Honggang, Wei, Mingming, Yang, Guang, Yang, Cheng

“…Cancer stem cells (CSCs) have been reported to be involved in tumorigenesis, tumor recurrence, cancer invasion, metastasis, and drug-resistance. Therefore, the…”
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Identification the shared pathogenesis between chronic hepatitis B and non-alcoholic fatty liver disease: Evidence from transcriptome data by Yang, Yan, Ge, Feilin, Qin, Shuanglin, Luo, Chen, Xiao, Xiaohe, Bai, Zhaofang, Tang, Chenglin

“…Background: The coexistence of Chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD) is becoming more prevalent, which not only exacerbates…”
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Bisindole natural products: A vital source for the development of new anticancer drugs by Xu, Mengwei, Peng, Rui, Min, Qing, Hui, Siwen, Chen, Xin, Yang, Guang, Qin, Shuanglin

“…Currently, the number of new cancer cases and deaths worldwide is increasing year on year. In addition to the requirement for cancer prevention, the top…”
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Superior strength-ductility combination in TiC/TC4 composites via In situ construction Ti2Cu nanoparticles by Mao, Xiaoqi, Dong, Longlong, Zhang, Yiya, Qin, Shuanglin, Sun, Guodong, Wang, Lianwen, Zhang, Yusheng

“…Synergistic improvement of strength and ductility is challenging in the engineering applications of titanium matrix composites (TMCs). Herein, we fabricated…”
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Ultrafine-grained copper alloy with remarkable improvement in strength and thermal stability at high temperatures by Qin, Shuanglin, Sun, Guodong, Mao, Xiaoqi, Zhang, Xiaoyan, Zhou, Bo, Li, Mingjia, Chang, Yongqin, Zhang, Yusheng, Wang, Lianwen, Li, Mingyang

“…In traditional dispersion-strengthened (DS) copper alloys, inert nanoparticles selected as strengthening phase were noncoherent or semi-coherent with the…”
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PROTAC technology: From drug development to probe technology for target deconvolution by Yan, Si, Zhang, Guangshuai, Luo, Wei, Xu, Mengwei, Peng, Rui, Du, Ziwei, Liu, Yan, Bai, Zhaofang, Xiao, Xiaohe, Qin, Shuanglin

“…Drug development remains a critical focus within the global pharmaceutical industry. To date, more than 80 % of disease targets are considered difficult to…”
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Network pharmacology-based strategy for predicting therapy targets of Ecliptae Herba on breast cancer by Li, Hui, Shi, Wei, Shen, Tingming, Hui, Siwen, Hou, Manting, Wei, Ziying, Qin, Shuanglin, Bai, Zhaofang, Cao, Junling

“…Breast cancer is a prevalent malignancy affecting women globally, characterized by significant morbidity and mortality rates. Ecliptae Herba is a traditional…”
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LicochalconeB inhibits cGAS-STING signaling pathway and prevents autoimmunity diseases by Luo, Wei, Song, Zheng, Xu, Guang, Wang, Hongbo, Mu, Wenqing, Wen, Jincai, Zhang, Ping, Qin, Shuanglin, Xiao, Xiaohe, Bai, Zhaofang

“…•LicoB is a potential and effective cGAS-STING signaling pathway inhibitor.•LicoB affected the STING-TBK1-IRF3 signal axis.•LicoB effectively diminished…”
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Flavonoids derived from licorice suppress LPS-induced acute lung injury in mice by inhibiting the cGAS-STING signaling pathway by Wen, Jincai, Qin, Shuanglin, Li, Yurong, Zhang, Ping, Zhan, Xiaoyan, Fang, Mingxia, Shi, Ce, Mu, Wenqing, Kan, Wen, Zhao, Jia, Hui, Siwen, Hou, Manting, Li, Hui, Xiao, Xiaohe, Xu, Guang, Bai, Zhaofang

“…In recent years, we have found that the dysregulation of the cyclic-GMP-AMP synthase (cGAS)‒stimulator of interferon genes (STING) pathway leads to the…”
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Iron/copper co-catalyzed highly selective arylation of sulfinamides with aryl iodides by Qin, Shuanglin, Luo, Yunhao, Sun, Yue, Tian, Le, Jiang, Shende, yan, Jun, Yang, Guang

“…[Display omitted] •Highly chemical selective: only react with aryl iodides.•Efficient C–N bond formation.•Environment-friendly and economic catalysts.•No…”
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Corrigendum to “Iron/copper co-catalyzed highly selective arylation of sulfinamides with aryl iodides” [Tetrahedron Lett. 60/43 (2019) 151167] by Qin, Shuanglin, Luo, Yunhao, Sun, Yue, Tian, Le, Jiang, Shende, yan, Jun, Yang, Guang

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Tryptanthrin suppresses multiple inflammasome activation to regulate NASH progression by targeting ASC protein by Ren, Lutong, Yang, Huijie, Wang, Hongbo, Qin, Shuanglin, Zhan, Xiaoyan, Li, Hui, Wei, Ziying, Fang, Zhie, Li, Qiang, Liu, Tingting, Shi, Wei, Zhao, Jia, Li, Zhiyong, Bai, Zhaofang, Xu, Guang, Zhao, Jun

“…The adaptor protein apoptosis-associated speck-like protein (ASC) containing a caspase recruitment domain (CARD) can be activated through pyrin domain (PYD)…”
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Helenine blocks NLRP3 activation by disrupting the NEK7-NLRP3 interaction and ameliorates inflammatory diseases by Fang, Zhi-E, Wang, Yan, Bian, Shuyi, Qin, Shuanglin, Zhao, Huanying, Wen, Jincai, Liu, Tingting, Ren, Lutong, Li, Qiang, Shi, Wei, Zhao, Jia, Yang, Huijie, Peng, Rui, Wang, Qin, Bai, Zhaofang, Xu, Guang

“…BACKGROUNDThe involvement of NLRP3 inflammasome is associated with the progress of numerous inflammatory conditions. However, there is currently no single…”
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Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics by Liu, Xueying, Zhang, Qian, Wang, Peili, Peng, Xin, An, Yehai, Chen, Junhui, Huang, Jingnan, Qin, Shuanglin, He, Hengkai, Hao, Mingjing, Tian, Jiahang, Yi, Letai, Lei, Ming, Luo, Piao, Wang, Jigang, Zhang, Xinzhou

“…Celastrol (Cel), derived from the traditional herb fordii Hook. f., has anti-inflammatory, anti-tumor, and immunoregulatory activities. Renal dysfunction,…”
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