Search Results - "Qin, LunXiu"

Lenvatinib Targets FGF Receptor 4 to Enhance Antitumor Immune Response of Anti–Programmed Cell Death‐1 in HCC by Yi, Chenhe, Chen, Lirong, Lin, Zhifei, Liu, Lu, Shao, Weiqing, Zhang, Rui, Lin, Jing, Zhang, Jubo, Zhu, Wenwei, Jia, Huliang, Qin, Lunxiu, Lu, Lu, Chen, Jinhong

“…Background and Aims Recently, clinical trials of lenvatinib plus pembrolizumab in HCC have displayed an impressive objective response rate. This study aimed to…”
Get full text

Osteopontin is a promoter for hepatocellular carcinoma metastasis： a summary of 10 years of studies by Qin, Lunxiu

“…In this review, we summarize the novel findings from our series of studies on the leading metastasis- related gene, osteopontin （OPN）. In our previous gene…”
Get full text

Current landscape and perspective of oncolytic viruses and their combination therapies by Su, Yinghan, Su, Changqing, Qin, Lunxiu

“…•Oncolytic virotherapy has become an important branch of cancer immunotherapy in clinical practice.•Multiple viruses can be engineered to be OVs and armed with…”
Get full text

Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma by Hou, Jin, Lin, Li, Zhou, Weiping, Wang, Zhengxin, Ding, Guoshan, Dong, Qiongzhu, Qin, Lunxiu, Wu, Xiaobing, Zheng, Yuanyuan, Yang, Yun, Tian, Wei, Zhang, Qian, Wang, Chunmei, Zhang, Qinghua, Zhuang, Shi-Mei, Zheng, Limin, Liang, Anmin, Tao, Wenzhao, Cao, Xuetao

“…The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal…”
Get full text

Lipid metabolism in cancer progression and therapeutic strategies by Fu, Yan, Zou, Tiantian, Shen, Xiaotian, Nelson, Peter J., Li, Jiahui, Wu, Chao, Yang, Jimeng, Zheng, Yan, Bruns, Christiane, Zhao, Yue, Qin, Lunxiu, Dong, Qiongzhu

“…Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent…”
Get full text

Regulation of Cellular Metabolism by Protein Lysine Acetylation by Zhao, Shimin, Xu, Wei, Jiang, Wenqing, Yu, Wei, Lin, Yan, Zhang, Tengfei, Yao, Jun, Zhou, Li, Zeng, Yaxue, Li, Hong, Li, Yixue, Shi, Jiong, An, Wenlin, Hancock, Susan M, He, Fuchu, Qin, Lunxiu, Chin, Jason, Yang, Pengyuan, Chen, Xian, Lei, Qunying, Xiong, Yue, Guan, Kun-Liang

“…Protein lysine acetylation has emerged as a key posttranslational modification in cellular regulation, in particular through the modification of histones and…”
Get full text

Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin by Min, Lihua, Ji, Yuan, Bakiri, Latifa, Qiu, Zhixin, Cen, Jin, Chen, Xiaotao, Chen, Lingli, Scheuch, Harald, Zheng, Hai, Qin, Lunxiu, Zatloukal, Kurt, Hui, Lijian, Wagner, Erwin F.

“…Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies…”
Get full text

EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma by Dong, Qiongzhu, Du, Yi, Li, Hui, Liu, Chunxiao, Wei, Yongkun, Chen, Mei-Kuang, Zhao, Xixi, Chu, Yu-Yi, Qiu, Yufan, Qin, Lunxiu, Yamaguchi, Hirohito, Hung, Mien-Chie

“…PARP1 inhibitors (PARPi) are currently used in the clinic for the treatment of ovarian and breast cancers, yet their therapeutic efficacy against…”
Get full text

Elevated G6PD expression contributes to migration and invasion of hepatocellular carcinoma cells by inducing epithelial-mesenchymal transition by Lu, Ming, Lu, Lu, Dong, Qiongzhu, Yu, Guangyang, Chen, Jinhong, Qin, Lunxiu, Wang, Lianxin, Zhu, Wenwei, Jia, Huliang

“…Abstract Altered metabolism is one of the hallmarks of cancer cells. Pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism…”
Get full text

LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3/Slug axis and epithelial-to-mesenchymal transition in gastric cancer by Zhao, Jing, Wu, Jing, Qin, Yunyun, Zhang, Wenhong, Huang, Guangjian, Qin, Lunxiu

“…Purpose Vasculogenic mimicry (VM), a vessel-like network formed by highly aggressive tumor cells, plays an important role in accelerating cancer progression…”
Get full text

Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer by Zheng, Yan, Wu, Chao, Yang, Jimeng, Zhao, Yue, Jia, Huliang, Xue, Min, Xu, Da, Yang, Feng, Fu, Deliang, Wang, Chaoqun, Hu, Beiyuan, Zhang, Ze, Li, Tianen, Yan, Shican, Wang, Xuan, Nelson, Peter J., Bruns, Christiane, Qin, Lunxiu, Dong, Qiongzhu

“…Enolase 2 (ENO2) is a key glycolytic enzyme in the metabolic process of glycolysis, but its potential function in pancreatic ductal adenocarcinoma (PDAC) is…”
Get full text

Exosomal S100A4 derived from highly metastatic hepatocellular carcinoma cells promotes metastasis by activating STAT3 by Sun, Haoting, Wang, Chaoqun, Hu, Beiyuan, Gao, Xiaomei, Zou, Tiantian, Luo, Qin, Chen, Mo, Fu, Yan, Sheng, Yuanyuan, Zhang, Kaili, Zheng, Yan, Ren, Xudong, Yan, Shican, Geng, Yan, Yang, Luyu, Dong, Qiongzhu, Qin, Lunxiu

“…Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely…”
Get full text

Liver X Receptor Agonism Sensitizes a Subset of Hepatocellular Carcinoma to Sorafenib by Dual-Inhibiting MET and EGFR by Shao, Weiqing, Zhu, Wenwei, Lin, Jing, Luo, Mengjun, Lin, Zhifei, Lu, Lu, Jia, Huliang, Qin, Lunxiu, Lu, Ming, Chen, Jinhong

“…Sorafenib is the first approved systemic therapy for advanced hepatocellular carcinoma (HCC) and is the first-line choice in clinic. Sustained activation of…”
Get full text

Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner by Qin, Zhaoyu, Xiang, Chan, Zhong, Fan, Liu, Yang, Dong, Qiongzhu, Li, Kai, Shi, Wenhao, Ding, Chen, Qin, Lunxiu, He, Fuchu

“…Metabolic reprogramming is one of the hallmarks of cancer cells. The pentose phosphate pathway (PPP), a branch of glycolysis, is an important metabolic pathway…”
Get full text

miR-192, a prognostic indicator, targets the SLC39A6/SNAIL pathway to reduce tumor metastasis in human hepatocellular carcinoma by Lian, Junwei, Jing, Ying, Dong, Qiongzhu, Huan, Lin, Chen, Di, Bao, Chunyang, Wang, Qifeng, Zhao, Fangyu, Li, Jinjun, Yao, Ming, Qin, Lunxiu, Liang, Linhui, He, Xianghuo

“…Metastasis is one of the causes of cancer death. Functions and mechanisms of microRNAs (miRNAs) involved in hepatocellular carcinoma (HCC) metastasis are…”
Get full text

Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma by Gao, Xiaomei, Sheng, Yuanyuan, Yang, Jing, Wang, Chaoqun, Zhang, Rui, Zhu, Ying, Zhang, Ze, Zhang, Kaili, Yan, Shican, Sun, Haoting, Wei, Jinwang, Wang, Xuan, Yu, Xinxin, Zhang, Yu, Luo, Qin, Zheng, Yan, Qiao, Peng, Zhao, Yue, Dong, Qiongzhu, Qin, Lunxiu

“…In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse and resistance to treatment…”
Get full text

In-hospital adverse outcomes and risk factors among chronic kidney disease patients infected with the omicron variant of SARS-CoV-2: a single-center retrospective study by Guo, Yue, Guo, Yifei, Ying, Huajian, Yu, Weien, Chen, Shiqi, Zhang, Yao, Zhang, Shenyan, Lin, Yanxue, Sun, Feng, Zhang, Yongmei, Yu, Jie, Ma, Ke, Qin, Lunxiu, Long, Feng, Zhu, Haoxiang, Mao, Richeng, Xue, Jun, Zhang, Jiming

“…Abstract Introduction The SARS-CoV-2 Omicron variant has decreased virulence and pathogenicity, yet the number of Omicron infections worldwide is…”
Get full text

Characteristics of pre-metastatic niche: the landscape of molecular and cellular pathways by Wang, Hao, Pan, Junjie, Barsky, Livnat, Jacob, Jule Caroline, Zheng, Yan, Gao, Chao, Wang, Shun, Zhu, Wenwei, Sun, Haoting, Lu, Lu, Jia, Huliang, Zhao, Yue, Bruns, Christiane, Vago, Razi, Dong, Qiongzhu, Qin, Lunxiu

“…Metastasis is a major contributor to cancer-associated deaths. It involves complex interactions between primary tumorigenic sites and future metastatic sites…”
Get full text

The m6A methylation landscape stratifies hepatocellular carcinoma into 3 subtypes with distinct metabolic characteristics by Shen, Xiaotian, Hu, Beiyuan, Xu, Jing, Qin, Wei, Fu, Yan, Wang, Shun, Dong, Qiongzhu, Qin, Lunxiu

“…Epigenetic aberration plays an important role in the development and progression of hepatocellular carcinoma (HCC). However, the alteration of RNA…”
Get full text

CAV1 promotes HCC cell progression and metastasis through Wnt/β-catenin pathway by Yu, Hongxiu, Shen, Huali, Zhang, Yang, Zhong, Fan, Liu, Yinkun, Qin, Lunxiu, Yang, Pengyuan

“…Caveolin-1 (CAV1) has significant roles in many primary tumors and metastasis, despite the fact that malignant cells from different cancer types have different…”
Get full text