Search Results - "Qin, F."
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Inference of immune cell composition on the expression profiles of mouse tissue
Published in Scientific reports (13-01-2017)“…Mice are some of the widely used experimental animal models for studying human diseases. Defining the compositions of immune cell populations in various…”
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2
Enhanced intrinsic photovoltaic effect in tungsten disulfide nanotubes
Published in Nature (London) (01-06-2019)“…The photovoltaic effect in traditional p – n junctions—where a p -type material (with an excess of holes) abuts an n -type material (with an excess of…”
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3
Tumor-Repopulating Cells Induce PD-1 Expression in CD8+ T Cells by Transferring Kynurenine and AhR Activation
Published in Cancer cell (12-03-2018)“…Despite the clinical successes fostered by immune checkpoint inhibitors, mechanisms underlying PD-1 upregulation in tumor-infiltrating T cells remain an…”
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4
Evolving roles of CD38 metabolism in solid tumour microenvironment
Published in British journal of cancer (16-02-2023)“…Given that plenty of clinical findings and reviews have already explained in detail on the progression of CD38 in multiple myeloma and haematological system…”
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IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor
Published in Nature immunology (01-03-2021)“…CD8 + T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular…”
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25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model
Published in Immunity (Cambridge, Mass.) (21-03-2017)“…Zika virus (ZIKV) has become a public health threat due to its global transmission and link to severe congenital disorders. The host immune responses to ZIKV…”
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SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
Published in Aging cell (01-08-2007)“…Summary The sirtuin family of nicotinamide adenine dinucleotide‐dependant (NAD) deacetylases plays an important role in aging and metabolic regulation. In…”
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8
Superconductivity in a chiral nanotube
Published in Nature communications (16-02-2017)“…Chirality of materials are known to affect optical, magnetic and electric properties, causing a variety of nontrivial phenomena such as circular dichiroism for…”
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Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
Published in Nature communications (10-05-2017)“…Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D…”
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Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Published in Nature communications (28-10-2014)“…Immunosuppression of tumour-infiltrating lymphocytes (TIL) is a common feature of advanced cancer, but its biological basis has remained obscure. We…”
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Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities
Published in Biochemical and biophysical research communications (19-02-2020)“…Ebola virus (EBOV), pathogen of Ebola hemorrhagic fever (EHF), is an enveloped filamental RNA virus. Recently, the EHF crisis occurred in the Democratic…”
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12
Omicron adopts a different strategy from Delta and other variants to adapt to host
Published in Signal transduction and targeted therapy (10-02-2022)Get full text
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13
Two Functional Subsets of FOXP3 + Regulatory T Cells in Human Thymus and Periphery
Published in Immunity (Cambridge, Mass.) (01-06-2008)“…Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and…”
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TRIM14 inhibits hepatitis C virus infection by SPRY domain-dependent targeted degradation of the viral NS5A protein
Published in Scientific reports (31-08-2016)“…Tripartite motif 14 (TRIM14) was reported to function as a mitochondrial signaling adaptor in mediating innate immune responses. However, the involvement of…”
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The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression
Published in Cell death & disease (05-07-2021)“…It has been recently reported that CD38 expressed on tumor cells of multiple murine and human origins could be upregulated in response to PD-L1 antibody…”
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Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance
Published in Immunology letters (01-04-2020)“…•Immunotherapy induces long lasting immune responses in cancer patients.•Immune checkpoint therapy with traditional treatment produces promising…”
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Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation
Published in Cell reports (Cambridge) (10-12-2019)“…To understand the molecular mechanisms that mediate the anti-hepatitis B virus (HBV) effect of interferon (IFN) therapy, we conduct high-throughput bimolecular…”
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A Novel Function of F-Box Protein FBXO17 in Negative Regulation of Type I IFN Signaling by Recruiting PP2A for IFN Regulatory Factor 3 Deactivation
Published in The Journal of immunology (1950) (15-01-2017)“…The F-box proteins were originally identified as the key component of SKP1-Cullin1-F-box E3 ligase complexes that control the stability of their specific…”
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cMyb regulates hematopoietic stem/progenitor cell mobilization during zebrafish hematopoiesis
Published in Blood (13-10-2011)“…The establishment of the HSC pool in vertebrates depends not only on the formation and the propagation of these stem cells but also on their proper trafficking…”
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Tissue-specific deconvolution of immune cell composition by integrating bulk and single-cell transcriptomes
Published in Bioinformatics (01-02-2020)“…Abstract Motivation Many methods have been developed to estimate immune cell composition from tissue transcriptomes. One common characteristic of these methods…”
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