Search Results - "Qin, Ann"

Organic Anion Transporting Polypeptide Inhibition Dramatically Increases Plasma Exposure but not Pharmacodynamic Effect nor Inferred Hepatic Intracellular Exposure of Firsocostat by Kirby, Brian J., Lutz, Justin D., Yue, Mun Sang, Garrison, Kimberly L., Qin, Ann Ran‐Ran, Ampaw, Lorraine, Beysen, Carine, Myers, Robert P., Kearney, Brian P., Mathias, Anita

“…Firsocostat (FIR: previously GS‐0976), a highly sensitive OATP substrate, reduces hepatic de novo lipogenesis (DNL) by inhibiting acetyl‐CoA carboxylases…”
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Evaluation of the Potential for Cytochrome P450 and Transporter-Mediated Drug–Drug Interactions for Firsocostat, a Liver-Targeted Inhibitor of Acetyl-CoA Carboxylase by Weber, Elijah J., Younis, Islam R., Nelson, Cara, Qin, Ann R., Watkins, Timothy R., Othman, Ahmed A.

“…Background and Objective Firsocostat is an oral, liver-targeted inhibitor of acetyl-CoA carboxylase in clinical development for the treatment of metabolic…”
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Pharmacokinetics and Safety of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, in Participants with Mild, Moderate, and Severe Hepatic Impairment by Younis, Islam R., Nelson, Cara, Weber, Elijah J., Qin, Ann R., Watkins, Timothy R., Othman, Ahmed A.

“…Firsocostat is an oral, liver‐targeted inhibitor of acetyl‐coenzyme A carboxylase in development for the treatment of metabolic dysfunction‐associated…”
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Pharmacokinetics and Safety of Cilofexor and Firsocostat in Healthy Japanese and Non-Japanese Participants by Younis, Islam R, Nelson, Cara, Weber, Elijah J, Shen, Gong, Qin, Ann R, Xiao, Deqing, Watkins, Timothy R, Othman, Ahmed A

“…Cilofexor, an oral farnesoid X receptor agonist, and firsocostat, an oral, liver-targeted inhibitor of acetyl-coenzyme A carboxylase, are being investigated in…”
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Pharmacokinetics, pharmacodynamics, and safety of GS‐3583, a FLT3 agonist Fc fusion protein, from single‐ascending‐dose phase I study in healthy participants by Dauki, Anees M., Rajakumaraswamy, Nishanthan, Trowe, Torsten, Weng, Winnie, Lin, Kai‐Wen, Elboudjwarej, Emon, Qin, Ann Ran‐Ran, Schwabe, Christian, Kuhne, Michelle R., Othman, Ahmed A.

“…Conventional dendritic cells subtype 1 (cDC1) play a vital role in the priming and expansion of tumor‐specific CD8+ T cells and their recruitment to tumor…”
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The Relative Bioavailability and Effects of Food and Acid‐Reducing Agents on Filgotinib Tablets in Healthy Subjects by Anderson, Kacey, Zheng, Hao, Kotecha, Mona, Cuvin, Jennifer, Scott, Bob, Sharma, Shringi, Qin, Ann Ran‐Ran, Namour, Florence, Xin, Yan

“…Filgotinib is a potent, selective Janus kinase‐1 inhibitor being developed to treat chronic inflammatory diseases. This phase 1 study in healthy subjects…”
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Evaluation of the potential drug interactions mediated through P‐gp, OCT2, and MATE1/2K with filgotinib in healthy subjects by Hsueh, Chia‐Hsiang, Anderson, Kacey, Shen, Gong, Yun, Chohee, Qin, Ann, Othman, Ahmed A.

“…Filgotinib, a preferential Janus Kinase‐1 inhibitor, is approved in Europe and Japan for treatment of rheumatoid arthritis and is being developed for treatment…”
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Supplementation of Nicotinic Acid with NAMPT Inhibitors Results in Loss of In Vivo Efficacy in NAPRT1 -Deficient Tumor Models by O'Brien, Thomas, Oeh, Jason, Xiao, Yang, Liang, Xiaorong, Vanderbilt, Alexander, Qin, Ann, Yang, Lulu, Lee, Leslie B, Ly, Justin, Cosino, Ely, LaCap, Jennifer A, Ogasawara, Annie, Williams, Simon, Nannini, Michelle, Liederer, Bianca M, Jackson, Peter, Dragovich, Peter S, Sampath, Deepak

“…Abstract Nicotinamide adenine dinucleotide (NAD) is a metabolite essential for cell survival and generated de novo from tryptophan or recycled from…”
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Evaluation of homogenization techniques for the preparation of mouse tissue samples to support drug discovery by Liang, Xiaorong, Ubhayakar, Savita, Liederer, Bianca M, Dean, Brian, Ran-Ran Qin, Ann, Shahidi-Latham, Sheerin, Deng, Yuzhong

“…In early drug-discovery research, understanding the tissue distribution of drug at the site of action can help to predict the toxicity, efficacy and exposure…”
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Measuring NAD(+) levels in mouse blood and tissue samples via a surrogate matrix approach using LC-MS/MS by Liang, Xiaorong, Yang, Lulu, Qin, Ann R, Ly, Justin, Liederer, Bianca M, Messick, Kirsten, Ma, Shuguang, Zak, Mark, Dragovich, Peter S, Dean, Brian J, Hop, Cornelis E C A, Deng, Yuzhong

“…NAD(+) is an endogenous analyte and is unstable during blood sample collection, both of which present obstacles for quantitation. Moreover, current procedures…”
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Collagenase as an effective tool for drug quantitation in tissues by Qin, Ann Ran-Ran, Liang, Xiaorong, Deng, Yuzhong, Dean, Brian, Shahidi-Latham, Sheerin K

“…In early drug-discovery research, traditional techniques to analyze drug concentrations in tissues for bioanalytical needs include bead beaters and probe…”
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Nanosuspension delivery of paclitaxel to xenograft mice can alter drug disposition and anti-tumor activity by Chiang, Po-Chang, Gould, Stephen, Nannini, Michelle, Qin, Ann, Deng, Yuzhong, Arrazate, Alfonso, Kam, Kimberly R, Ran, Yingqing, Wong, Harvey

“…Paclitaxel is a common chemotherapeutic agent that is effective against various cancers. The poor aqueous solubility of paclitaxel necessitates a large…”
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A reversed sulfonamide series of selective RORc inverse agonists by van Niel, Monique B., Fauber, Benjamin P., Cartwright, Matthew, Gaines, Simon, Killen, Jonathan C., René, Olivier, Ward, Stuart I., de Leon Boenig, Gladys, Deng, Yuzhong, Eidenschenk, Céline, Everett, Christine, Gancia, Emanuela, Ganguli, Arunima, Gobbi, Alberto, Hawkins, Julie, Johnson, Adam R., Kiefer, James R., La, Hank, Lockey, Peter, Norman, Maxine, Ouyang, Wenjun, Qin, Ann, Wakes, Nicole, Waszkowycz, Bohdan, Wong, Harvey

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Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X Receptor Agonist by Weber, Elijah, Younis, Islam R., Nelson, Cara, Ding, Dora, Qin, Ann, Xiao, Deqing, Watkins, Timothy R., Othman, Ahmed A.

“…Firsocostat, a liver‐targeted acetyl‐coenzyme A carboxylase inhibitor, and cilofexor, a nonsteroidal farnesoid X receptor agonist, are being developed in…”
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FRI094 - The safety and pharmacokinetics of fenofibrate in patients with advanced fibrosis including those with non-alcoholic steatohepatitis (NASH) by Weber, Elijah, Nelson, Cara, Qin, Ann, Huss, Ryan, Camargo, Marianne, Myers, Robert, Li, Shirley, Zhang, Jie, Kirby, Brian

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The safety and pharmacokinetics of fenofibrate in patients with advanced fibrosis including those with non-alcoholic steatohepatitis (NASH) by Weber, Elijah, Nelson, Cara, Qin, Ann, Huss, Ryan, Camargo, Marianne, Myers, Robert, Li, Shirley, Zhang, Jie, Kirby, Brian

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Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug–Drug Interactions by Ly, Justin Q, Messick, Kirsten, Qin, Ann, Takahashi, Ryan H, Choo, Edna F

“…Species differences in the expression, activity, regulation, and substrate specificity of metabolizing enzymes preclude the use of animal models to predict…”
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Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor by Choo, Edna F, Woolsey, Sarah, DeMent, Kevin, Ly, Justin, Messick, Kirsten, Qin, Ann, Takahashi, Ryan

“…Data from the clinical absolute bioavailability (F) study with cobimetinib suggested that F was lower than predicted based on its low hepatic extraction and…”
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Lack of Drug‐Drug Interaction Between Filgotinib, a Selective JAK1 Inhibitor, and Oral Hormonal Contraceptives Levonorgestrel/Ethinyl Estradiol in Healthy Volunteers by Begley, Rebecca, Anderson, Kacey, Watkins, Timothy R., Weng, Winnie, Ampaw, Lorraine, Qin, Ann, Kearney, Brian P., Mathias, Anita

“…Filgotinib (FIL) is a potent and selective JAK1 inhibitor in clinical development for treatment of severe inflammatory diseases. A drug‐drug interaction study…”
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Measuring Nad + Levels in Mouse Blood and Tissue Samples Via A Surrogate Matrix Approach Using LC–MS/MS by Liang, Xiaorong, Yang, Lulu, Qin, Ann R, Ly, Justin, Liederer, Bianca M, Messick, Kirsten, Ma, Shuguang, Zak, Mark, Dragovich, Peter S, Dean, Brian J, Hop, Cornelis ECA, Deng, Yuzhong

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