Search Results - "Qiao, Renping"

Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming by Martinez-Chacin, Raquel C., Bodrug, Tatyana, Bolhuis, Derek L., Kedziora, Katarzyna M., Bonacci, Thomas, Ordureau, Alban, Gibbs, Morgan E., Weissmann, Florian, Qiao, Renping, Grant, Gavin D., Cook, Jeanette G., Peters, Jan-Michael, Wade Harper, J., Emanuele, Michael J., Brown, Nicholas G.

“…The interplay between E2 and E3 enzymes regulates the polyubiquitination of substrates in eukaryotes. Among the several RING-domain E3 ligases in humans, many…”
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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex by Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Qiao, Renping, Grace, Christy R. R., Yamaguchi, Masaya, Weissmann, Florian, Frye, Jeremiah J., Dube, Prakash, Cho, Shein Ei, Actis, Marcelo L., Rodrigues, Patrick, Fujii, Naoaki, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Significance The anaphase-promoting complex/cyclosome (APC) is a multisubunit RING E3 ubiquitin (Ub) ligase that regulates mitosis, meiosis, and numerous…”
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Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly by Brown, Nicholas G., Watson, Edmond R., Weissmann, Florian, Jarvis, Marc A., VanderLinden, Ryan, Grace, Christy R.R., Frye, Jeremiah J., Qiao, Renping, Dube, Prakash, Petzold, Georg, Cho, Shein Ei, Alsharif, Omar, Bao, Ju, Davidson, Iain F., Zheng, Jie J., Nourse, Amanda, Kurinov, Igor, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Polyubiquitination by E2 and E3 enzymes is a predominant mechanism regulating protein function. Some RING E3s, including anaphase-promoting complex/cyclosome…”
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Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs by Huang, Huang, Qiao, Renping, Zhao, Deyao, Zhang, Tong, Li, Youxian, Yi, Fan, Lai, Fangfang, Hong, Junmei, Ding, Xianfeng, Yang, Zhenjun, Zhang, Lihe, Du, Quan, Liang, Zicai

“…Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP)…”
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Mechanism of APC/C CDC20 activation by mitotic phosphorylation by Qiao, Renping, Weissmann, Florian, Yamaguchi, Masaya, Brown, Nicholas G., VanderLinden, Ryan, Imre, Richard, Jarvis, Marc A., Brunner, Michael R., Davidson, Iain F., Litos, Gabriele, Haselbach, David, Mechtler, Karl, Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael

“…Significance The ability of eukaryotic cells to pass their genomes properly from one cell generation to the next depends on the 1.2-MDa ubiquitin ligase…”
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Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation by Yamaguchi, Masaya, VanderLinden, Ryan, Weissmann, Florian, Qiao, Renping, Dube, Prakash, Brown, Nicholas G., Haselbach, David, Zhang, Wei, Sidhu, Sachdev S., Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…The mitotic checkpoint complex (MCC) coordinates proper chromosome biorientation on the spindle with ubiquitination activities of CDC20-activated…”
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Real-Time Monitoring of APC /C-Mediated Substrate Degradation Using Xenopus laevis Egg Extracts by Kamenz, Julia, Qiao, Renping, Yang, Qiong, Ferrell, Jr, James E

“…The anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase, is a key regulator of mitotic progression. Upon activation in mitosis, the APC/C…”
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SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly by Qiao, Renping, Cabral, Gabriela, Lettman, Molly M, Dammermann, Alexander, Dong, Gang

“…The centriole is a conserved microtubule‐based organelle essential for both centrosome formation and cilium biogenesis. Five conserved proteins for centriole…”
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Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C by Brown, Nicholas G., VanderLinden, Ryan, Watson, Edmond R., Weissmann, Florian, Ordureau, Alban, Wu, Kuen-Phon, Zhang, Wei, Yu, Shanshan, Mercredi, Peter Y., Harrison, Joseph S., Davidson, Iain F., Qiao, Renping, Lu, Ying, Dube, Prakash, Brunner, Michael R., Grace, Christy R.R., Miller, Darcie J., Haselbach, David, Jarvis, Marc A., Yamaguchi, Masaya, Yanishevski, David, Petzold, Georg, Sidhu, Sachdev S., Kuhlman, Brian, Kirschner, Marc W., Harper, J. Wade, Peters, Jan-Michael, Stark, Holger, Schulman, Brenda A.

“…Protein ubiquitination involves E1, E2, and E3 trienzyme cascades. E2 and RING E3 enzymes often collaborate to first prime a substrate with a single ubiquitin…”
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Structure of an APC3–APC16 Complex: Insights into Assembly of the Anaphase-Promoting Complex/Cyclosome by Yamaguchi, Masaya, Yu, Shanshan, Qiao, Renping, Weissmann, Florian, Miller, Darcie J., VanderLinden, Ryan, Brown, Nicholas G., Frye, Jeremiah J., Peters, Jan-Michael, Schulman, Brenda A.

“…The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory…”
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Structure of the C. elegans ZYG-1 Cryptic Polo Box Suggests a Conserved Mechanism for Centriolar Docking of Plk4 Kinases by Shimanovskaya, Ekaterina, Viscardi, Valeria, Lesigang, Johannes, Lettman, Molly M., Qiao, Renping, Svergun, Dmitri I., Round, Adam, Oegema, Karen, Dong, Gang

“…Plk4 family kinases control centriole assembly. Plk4s target mother centrioles through an interaction between their cryptic polo box (CPB) and acidic regions…”
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Mechanism of APC/C^sup CDC20^ activation by mitotic phosphorylation by Qiao, Renping, Weissmann, Florian, Yamaguchi, Masaya, Brown, Nicholas G, VanderLinden, Ryan, Imre, Richard, Jarvis, Marc A, Brunner, Michael R, Davidson, Iain F, Litos, Gabriele, Haselbach, David, Mechtler, Karl, Stark, Holger, Schulman, Brenda A, Peters, Jan-Michael

“…Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20…”
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SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly: SAS-6 coiled-coil structure and interaction with SAS-5 by Qiao, Renping, Cabral, Gabriela, Lettman, Molly M, Dammermann, Alexander, Dong, Gang

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Mechanism of APC/CCDC20 activation by mitotic phosphorylation by Qiao, Renping, Weissmann, Florian, Yamaguchi, Masaya, Brown, Nicholas G., VanderLinden, Ryan, Imre, Richard, Jarvis, Marc A., Brunner, Michael R., Davidson, Iain F., Litos, Gabriele, Haselbach, David, Mechtler, Karl, Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael

“…Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20…”
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The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegans by Shimanovskaya, Ekaterina, Qiao, Renping, Lesigang, Johannes, Dong, Gang

“…The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. It has a unique 9-fold symmetry and its…”
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Focusing on RISC assembly in mammalian cells by Hong, Junmei, Wei, Na, Chalk, Alistair, Wang, Jue, Song, Yutong, Yi, Fan, Qiao, Ren-Ping, Sonnhammer, Erik L.L., Wahlestedt, Claes, Liang, Zicai, Du, Quan

“…RISC (RNA-induced silencing complex) is a central protein complex in RNAi, into which a siRNA strand is assembled to become effective in gene silencing. By…”
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The SAS-5 N-terminal domain is a tetramer, with implications for centriole assembly in C. elegans by Shimanovskaya, Ekaterina, Qiao, Renping, Lesigang, Johannes, Dong, Gang

“…The centriole is a conserved microtubule-based organelle essential for both centrosome formation and cilium biogenesis. It has a unique 9-fold symmetry and its…”
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