Collection of autologous peripheral hematopoietic stem cells in patients with sequential double transplantation of solid tumors and effect analysis

Collection of autologous peripheral hematopoietic stem cells in patients with sequential double transplantation of solid tumors and effect analysis

Objective To explore the methods and safety of autologous peripheral hematopoietic stem cells collection in patients with sequential double transplantation of solid tumors and conduct efficacy analysis. Methods Peripheral blood stem cells were collected from 27 patients with solid tumors after routi...

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Bibliographic Details
Published in:Zhongguo shu xue za zhi Vol. 35; no. 3; pp. 269 - 271
Main Authors: Ying ZHANG, Yushuang LIU, Qianxia ZHUANG, Nanhai WU, Zhouyang LIU, Hongyan LIU, Qi LIU, Zikuan GUO, Yuan SUN
Format: Journal Article
Language:Chinese
Published: Institute of Blood Transfusion of Chinese Academy of Medical Sciences 01-03-2022
Subjects:
cell collection
double autologous hematopoietic stem cell transplantation
low weight pediatric patients
solid tumor
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Summary:Objective To explore the methods and safety of autologous peripheral hematopoietic stem cells collection in patients with sequential double transplantation of solid tumors and conduct efficacy analysis. Methods Peripheral blood stem cells were collected from 27 patients with solid tumors after routine mobilization of rhG-CSF and rhGM-CSF.A specific program was made for the patients.The condition and cooperation degree of children were comprehensively evaluated before cell collection, and a femoral venous catheterization was inserted to ensure the cells collected smoothly.A mononuclear cell collection(MNC) program was selected, and machine parameters were set based on the patient's low body weight.The number of mononuclear cell (MNC) and the CD34+ cell was detected by flow cytometry for retrospective analysis. Results A total of 73 cell collections were performed in 27 patients, and the number of mononuclear cells and CD34+ cells was 12.586(10.22~19.586)×108/kg and 13.575(7.275~23.825)×106/kg, respectively, wh
ISSN:1004-549X
DOI:10.13303/j.cjbt.issn.1004-549x.2022.03.009