Search Results - "Qian, Zhanyang"

Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1α/DRP1 signaling pathway by Zhang, Yanan, Deng, Qian, Hong, Hongxiang, Qian, Zhanyang, Wan, Bowen, Xia, Mingjie

“…The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of microglia-mediated…”
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Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury by Jiang, Fan, Xia, Mingjie, Zhang, Yanan, Chang, Jie, Cao, Jiang, Zhang, Zhongkai, Qian, Zhanyang, Yang, Lei

“…Background Neuroinflammation following spinal cord injury (SCI) results in prolonged neurological damage and locomotor dysfunction. Polarization of microglia…”
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Activation of glucagon-like peptide-1 receptor in microglia attenuates neuroinflammation-induced glial scarring via rescuing Arf and Rho GAP adapter protein 3 expressions after nerve injury by Qian, Zhanyang, Chen, Hongtao, Xia, Mingjie, Chang, Jie, Li, Xinyu, Ye, Suhui, Wu, Shunjie, Jiang, Shuai, Bao, Junping, Wang, Binyu, Kong, Renyi, Zhang, Sheng, Zheng, Shengnai, Cao, Xiaojian, Hong, Xin

“…The neuroinflammation is necessary for glial group initiation and clearance of damaged cell debris after nerve injury. However, the proinflammatory…”
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Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury by Chang, Jie, Qian, Zhanyang, Wang, Binyu, Cao, Jiang, Zhang, Sheng, Jiang, Fan, Kong, Renyi, Yu, Xiao, Cao, Xiaojian, Yang, Lei, Chen, Hongtao

“…Limited progress in terms of an effective treatment for spinal cord injury (SCI) emphasizes the urgent need for novel therapies. As a vital central nervous…”
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Growth Differentiation Factor 15 Regulates Oxidative Stress-Dependent Ferroptosis Post Spinal Cord Injury by Stabilizing the p62-Keap1-Nrf2 Signaling Pathway by Xia, Mingjie, Zhang, Qinyang, Zhang, Yanan, Li, Rulin, Zhao, Tianyu, Chen, Lingxia, Liu, Qiangxian, Zheng, Shengnai, Li, Haijun, Qian, Zhanyang, Yang, Lei

“…Background Spinal cord injury (SCI) is a severe traumatic disorder of the central nervous system (CNS) that causes irreversible damage to the nervous tissue…”
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Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy by Chen, Hongtao, Qian, Zhanyang, Zhang, Sheng, Tang, Jian, Fang, Le, Jiang, Fan, Ge, Dawei, Chang, Jie, Cao, Jiang, Yang, Lei, Cao, Xiaojian

“…Skeletal muscle atrophy with high prevalence can induce weakness and fatigability and place huge burden on both health and quality of life. During skeletal…”
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LINC00266-1/miR-548c-3p/SMAD2 feedback loop stimulates the development of osteosarcoma by Zheng, Shengnai, Wan, Li, Ge, Dawei, Jiang, Fan, Qian, Zhanyang, Tang, Jian, Yang, Jin, Yao, Yilun, Yan, Junwei, Zhao, Lei, Li, Haijun, Yang, Lei

“…Osteosarcoma (OS) is one of the most common primary bone malignancies and accounts for 3.4% of pediatric tumors. Its 5-year survival is as low as about 20%…”
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Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury by Qian, Zhanyang, Li, Rulin, Zhao, Tianyu, Xie, Kunxin, Li, PengFei, Li, Guangshen, Shen, Na, Gong, Jiamin, Hong, Xin, Yang, Lei, Li, Haijun

“…Mechanical spinal cord injury (SCI) is a deteriorative neurological disorder, causing secondary neuroinflammation and neuropathy. ADAM8 is thought to be an…”
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Silencing TAK1 reduces MAPKs-MMP2/9 expression to reduce inflammation-driven neurohistological disruption post spinal cord injury by Jiang, Shuai, Wu, Yandan, Wu, Shunjie, Ye, Suhui, Kong, Renyi, Chang, Jie, Xia, Mingjie, Bao, Junping, Peng, Xin, Hong, Xin, Qian, Zhanyang, Li, Haijun

“…Microglia activation post traumatic spinal cord injury (SCI) provokes accumulation of inflammatory metabolites, leading to increasing neurological disruption…”
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FANCC deficiency mediates microglial pyroptosis and secondary neuronal apoptosis in spinal cord contusion by Xia, Mingjie, Li, Xinyu, Ye, Suhui, Zhang, Qinyang, Zhao, Tianyu, Li, Rulin, Zhang, Yanan, Xian, Minghan, Li, Tianqi, Li, Haijun, Hong, Xin, Zheng, Shengnai, Qian, Zhanyang, Yang, Lei

“…Traumatic spinal cord injury (SCI)-induced neuroinflammation results in secondary neurological destruction and functional disorder. Previous findings showed…”
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Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells by Bao, Junping, Qian, Zhanyang, Liu, Lei, Hong, Xin, Che, Hui, Wu, Xiaotao

“…Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we…”
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ACOD1, rather than itaconate, facilitates p62‐mediated activation of Nrf2 in microglia post spinal cord contusion by Qian, Zhanyang, Xia, Mingjie, Zhao, Tianyu, Li, You, Li, Guangshen, Zhang, Yanan, Li, Haijun, Yang, Lei

“…Background Spinal cord injury (SCI)‐induced neuroinflammation and oxidative stress (OS) are crucial events causing neurological dysfunction. Aconitate…”
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Corrigendum: miR-766-3p targeting BCL9L suppressed tumorigenesis, epithelial-mesenchymal transition, and metastasis through the β-catenin signaling pathway in osteosarcoma cells by Zhang, Sheng, Chen, Hongtao, Liu, Wanshun, Fang, Le, Qian, Zhanyang, Kong, Renyi, Zhang, Qi, Li, Juming, Cao, Xiaojian

“…[This corrects the article DOI: 10.3389/fcell.2020.594135.]…”
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miR-766-3p Targeting BCL9L Suppressed Tumorigenesis, Epithelial-Mesenchymal Transition, and Metastasis Through the β-Catenin Signaling Pathway in Osteosarcoma Cells by Zhang, Sheng, Chen, Hongtao, Liu, Wanshun, Fang, Le, Qian, Zhanyang, Kong, Renyi, Zhang, Qi, Li, Juming, Cao, Xiaojian

“…Accumulating evidence has indicated that abnormal microRNAs (miRNAs) serve critical roles in carcinogenesis and development of osteosarcoma (OS). The purpose…”
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Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway by Qian, Zhanyang, Chang, Jie, Jiang, Fan, Ge, Dawei, Yang, Lei, Li, You, Chen, Hongtao, Cao, Xiaojian

“…•P38 serves as a direct target of miR-340-5p.•miR-340-5p overexpression attenuates neuroinflammation both in vitro and in vivo SCI models.•miR-340-5p mimics…”
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An update of interbody cages for spine fusion surgeries: from shape design to materials by Li, Guangshen, Yang, Lei, Wu, Gang, Qian, Zhanyang, Li, Haijun

“…Discectomy and interbody fusion are widely used in the treatment of intervertebral disc-related diseases. Among them, the interbody cage plays a significant…”
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Deficiency of CD93 exacerbates inflammation-induced activation and migration of BV2 microglia by regulating the TAK1/NF-κB pathway by Hong, Xin, Xia, Mingjie, Zhang, Qinyang, Zhao, Tianyu, Zhang, Yanan, Qian, Zhanyang, Bao, Junping, Li, Haijun

“…•CD93 mainly expresses in microglia21 and injured spinal cord.•Knockdown of CD93 aggravates microglia inflammation.•Knockdown of CD93 promotes microglia…”
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Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury by Xia, Mingjie, Zhang, Yanan, Wu, Honghui, Zhang, Qinyang, Liu, Qiangxian, Li, Guangshen, Zhao, Tianyu, Liu, Xuepeng, Zheng, Shengnai, Qian, Zhanyang, Li, Haijun

“…•FTS•B attenuates microglia-mediated neuro-inflammation and secondary neuronal apoptosis post SCI.•FTS•B inhibits neuro-inflammation by downregulation of NF-κB…”
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Caffeic acid phenethyl ester inhibits neuro-inflammation and oxidative stress following spinal cord injury by mitigating mitochondrial dysfunction via the SIRT1/PGC1[alpha]/DRP1 signaling pathway by Zhang, Yanan, Deng, Qian, Hong, Hongxiang, Qian, Zhanyang, Wan, Bowen, Xia, Mingjie

“…Background The treatment of spinal cord injury (SCI) has always been a significant research focus of clinical neuroscience, with inhibition of…”
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A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway by Qian, Zhanyang, Zhang, Qinyang, Li, Pengfei, Li, Yang, Zhang, Yanan, Li, Rulin, Zhao, Tianyu, Xia, Mingjie, Chen, Yongyi, Hong, Xin

“…Ferroptosis is a type of iron-dependent programmed cell death caused by the imbalance between oxidants and antioxidants. A disintegrin and metalloproteinase-8…”
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