Search Results - "Qian, Shiguang"

Hepatic Stellate Cells Directly Inhibit B Cells via Programmed Death-Ligand 1 by Li, Yan, Lu, Lina, Qian, Shiguang, Fung, John J, Lin, Feng

“…We demonstrated previously that mouse hepatic stellate cells (HSCs) suppress T cells via programmed death-ligand 1 (PD-L1), but it remains unknown whether they…”
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Rejection triggers liver transplant tolerance: Involvement of mesenchyme‐mediated immune control mechanisms in mice by Morita, Miwa, Joyce, Daniel, Miller, Charles, Fung, John J., Lu, Lina, Qian, Shiguang

“…Liver tolerance was initially recognized by the spontaneous acceptance of liver allografts in many species. The underlying mechanisms are not completely…”
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Myeloid-derived suppressor cells as a potential therapy for experimental autoimmune myasthenia gravis by Li, Yan, Tu, Zhidan, Qian, Shiguang, Fung, John J, Markowitz, Sanford D, Kusner, Linda L, Kaminski, Henry J, Lu, Lina, Lin, Feng

“…We recently demonstrated that hepatic stellate cells induce the differentiation of myeloid-derived suppressor cells (MDSCs) from myeloid progenitors. In this…”
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Hepatic immune tolerance induced by hepatic stellate cells by Hsieh, Ching-Chuan, Hung, Chien-Hui, Lu, Lina, Qian, Shiguang

“…The liver, which is a metabolic organ, plays a pivotal role in tolerance induction. Hepatic stellate cells(Hp SCs), which are unique non-parenchymal cells,…”
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In vivo immune modulatory activity of hepatic stellate cells in mice by Chen, Cheng‐Hsu, Kuo, Liang‐Mou, Chang, Yigang, Wu, Wenhan, Goldbach, Christina, Ross, Mark A., Stolz, Donna B., Chen, Liepin, Fung, John J., Lu, Lin, Qian, Shiguang

“…Accumulating data suggest that hepatic tolerance, initially demonstrated by spontaneous acceptance of liver allografts in many species, results from an immune…”
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Inhibition of T‐cell responses by hepatic stellate cells via B7‐H1–mediated T‐cell apoptosis in mice by Yu, Ming‐Chin, Chen, Cheng‐Hsu, Liang, Xiaoyan, Wang, Lianfu, Gandhi, Chandrashekhar R., Fung, John J., Lu, Lina, Qian, Shiguang

“…In the injured liver, hepatic stellate cells (HSCs) secrete many different cytokines, recruit lymphocytes, and thus participate actively in the pathogenesis of…”
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Induced pluripotent stem cells-derived myeloid-derived suppressor cells regulate the CD8+ T cell response by Joyce, Daniel, Fujino, Masayuki, Morita, Miwa, Araki, Ryoko, Fung, John, Qian, Shiguang, Lu, Lina, Li, Xiao-Kang

“…Myeloid-derived suppressor cells (MDSCs) are markedly increased in cancer patients and tumor-bearing mice and promote tumor growth and survival by inhibiting…”
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Mechanistic insights into immunomodulation by hepatic stellate cells in mice: A critical role of interferon‐γ signaling by Yang, Horng‐Ren, Chou, Hong‐Shuie, Gu, Xiaodong, Wang, Lianfu, Brown, Kathleen E., Fung, John J., Lu, Lina, Qian, Shiguang

“…The liver is considered to be an immune‐privileged organ that favors the induction of tolerance. The underlying mechanisms are not completely understood…”
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Hepatic Stellate Cells Preferentially Expand Allogeneic CD4+CD25+FoxP3+ Regulatory T Cells in an IL-2-Dependent Manner by GUOPING JIANG, YANG, Horng-Ren, LIANFU WANG, WILDEY, Gary M, FUNG, John, SHIGUANG QIAN, LINA LU

“…Organ transplantation has been successfully practiced for decades, but the outcome of cell transplantation remains disappointing. This is the case in animal…”
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A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection by Jenh, Chung-Her, Cox, Mary Ann, Cui, Long, Reich, Eva-Pia, Sullivan, Lee, Chen, Shu-Cheng, Kinsley, David, Qian, Shiguang, Kim, Seong Heon, Rosenblum, Stuart, Kozlowski, Joseph, Fine, Jay S, Zavodny, Paul J, Lundell, Daniel

“…The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1…”
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A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection by Jenh, Chung-Her, Cox, Mary Ann, Cui, Long, Reich, Eva-Pia, Sullivan, Lee, Chen, Shu-Cheng, Kinsley, David, Qian, Shiguang, Kim, Seong Heon, Rosenblum, Stuart, Kozlowski, Joseph, Fine, Jay S, Zavodny, Paul J, Lundell, Daniel

“…The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1…”
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Interferon-γ Triggers Hepatic Stellate Cell-Mediated Immune Regulation through MEK/ERK Signaling Pathway by Qian, Shiguang, Wang, Lianfu, Chen, Zongyou, Xiang, Jianbin, Wang, Yan, Gu, Xiaodong, Lu, Lina

“…Hepatic stellate cells (HSCs) interact with immune cells to actively participate in regulating immune response in the liver which is mediated by the effector…”
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Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27 by Chen, Yun, Jiang, Guoping, Yang, Horng-Ren, Gu, Xiaodong, Wang, Lianfu, Hsieh, Ching-Chuan, Chou, Hong-Shiue, Fung, John J, Qian, Shiguang, Lu, Lina

“…Background/Aims The liver lies downstream of the gut, and is constantly exposed to bacteria. Liver dendritic cells (DC) are known to possess properties of…”
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Hepatic Stellate Cells Regulate Immune Response by Way of Induction of Myeloid Suppressor Cells in Mice by CHOU, Hong-Shiue, HSIEH, Ching-Chuan, LINA LU, SHIGUANG QIAN, YANG, Horng-Ren, LIANFU WANG, ARAKAWA, Yusuke, BROWN, Kathleen, QINGYU WU, FENG LIN, PETERS, Marion, FUNG, John J

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C-C Chemokine Receptor Type 2–Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants by Qin, Jie, Arakawa, Yusuke, Morita, Miwa, Fung, John J., Qian, Shiguang, Lu, Lina

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Evidence for a Role of IL-17 in Organ Allograft Rejection: IL-17 Promotes the Functional Differentiation of Dendritic Cell Progenitors by Antonysamy, Mary A, Fanslow, William C, Fu, Fumin, Li, Wei, Qian, Shiguang, Troutt, Anthony B, Thomson, Angus W

“…IL-17 is a T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. We hypothesized that IL-17 might play a…”
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Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-κB Activity by Ma, Linlin, Qian, Shiguang, Liang, Xiaoyan, Wang, Lianfu, Woodward, Jennifer E., Giannoukakis, Nick, Robbins, Paul D., Bertera, Suzanne, Trucco, Massimo, Fung, John J., Lu, Lina

“…Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-κB Activity Linlin Ma 1 , Shiguang Qian 1 ,…”
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Tolerance-Inducing Strategies in Islet Transplantation by Bhatt, Sumantha, Fung, John J., Lu, Lina, Qian, Shiguang

“…Allogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients. Current use of immunosuppressive therapies…”
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Prolongation of cardiac allograft survival by systemic administration of immature recipient dendritic cells deficient in NF-κB activity by TIAO, Mao-Meng, LINA LU, RAN TAO, LIANFU WANG, FUNG, John J, SHIGUANG QIAN

“…We developed a more applicable approach to use recipient-derived immature dendritic cells (DC) for deceased donor organ transplantation. In contrast to…”
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Immunosuppressive Effects of Glucosamine by Ma, Linlin, Rudert, William A, Harnaha, Jo, Wright, Marietta, Machen, Jennifer, Lakomy, Robert, Qian, Shiguang, Lu, Lina, Robbins, Paul D, Trucco, Massimo, Giannoukakis, Nick

“…Glucosamine is a naturally occurring derivative of glucose and is an essential component of glycoproteins and proteoglycans, important constituents of many…”
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