Search Results - "Qian, Qijun"

Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor by Zhang, Zhiwei, Jiang, Duqing, Yang, Huan, He, Zhou, Liu, Xiangzhen, Qin, Wenxia, Li, Linfang, Wang, Chao, Li, Yang, Li, He, Xu, Hai, Jin, Huajun, Qian, Qijun

“…Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we…”
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Chimeric antigen receptor T cells engineered to secrete CD40 agonist antibodies enhance antitumor efficacy by Zhang, Yajun, Wang, Pei, Wang, Tengjiao, Fang, Yuan, Ding, Yongmei, Qian, Qijun

“…Although chimeric antigen receptor (CAR)-T cell therapy has been remarkably successful for haematological malignancies, its efficacy against solid tumors is…”
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An efficient Screening System in Yeast to Select a Hyperactive piggyBac Transposase for Mammalian Applications by Wen, Wen, Song, Shanshan, Han, Yuchun, Chen, Haibin, Liu, Xiangzhen, Qian, Qijun

“…As non-viral transgenic vectors, the transposon system represents an attractive tool for gene delivery to achieve a long-term gene expression in immunotherapy…”
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Is Adjuvant Cellular Immunotherapy Essential after TACE-Predominant Minimally-Invasive Treatment for Hepatocellular Carcinoma? A Systematic Meta-Analysis of Studies Including 1774 Patients by Ding, Min, Wang, Ying, Chi, Jiachang, Wang, Tao, Tang, Xiaoyin, Cui, Dan, Qian, Qijun, Zhai, Bo

“…Cellular immunotherapy has appeared to be a promising modality for the treatment of malignant tumor. The objective of this study was to evaluate the efficacy…”
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Rapid response in relapsed follicular lymphoma with massive chylous ascites to anti-CD19 CAR T therapy using Piggy Bac: A case report by Zhang, Yan, Lin, Zhicai, Zhang, Faliang, Chen, Xiuxiu, Yang, Yaping, Fu, Xin, Li, Zhong, Sun, Yan, Qian, Qijun

“…CD19-directed chimeric antigen receptor (CAR) T cell therapy has been shown to achieve a considerably durable response in patients with refractory or relapsed…”
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Evaluation of Nonviral piggyBac and lentiviral Vector in Functions of CD19chimeric Antigen Receptor T Cells and Their Antitumor Activity for CD19 + Tumor Cells by Lin, Zhicai, Liu, Xiangzhen, Liu, Tao, Gao, Haixia, Wang, Sitong, Zhu, Xingli, Rong, Lijie, Cheng, Jingbo, Cai, Zhigang, Xu, Fu, Tan, Xue, Lv, Linjie, Li, Zhong, Sun, Yan, Qian, Qijun

“…Nonviral transposon (PB) and (LV) vectors have been used to deliver chimeric antigen receptor (CAR) to T cells. To understand the differences in the effects of…”
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αPD-1-mesoCAR-T cells partially inhibit the growth of advanced/refractory ovarian cancer in a patient along with daily apatinib by Fang, Juemin, Ding, Na, Guo, Xinling, Sun, Yan, Zhang, Zhiwei, Xie, Bailu, Li, Zhong, Wang, Hui, Mao, Wei, Lin, Zhicai, Qin, Fei, Yuan, Min, Chu, Wenqi, Qin, Huanlong, Qian, Qijun, Xu, Qing

“…Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological malignancies in China. In particular, advanced/refractory ovarian cancer…”
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Single-cell RNA-Seq reveals the potential risk of anti-mesothelin CAR T Cell therapy toxicity to different organs in humans by Wen, Lu, Huang, Yu, Peng, Ling, Zhao, Kaiping, Sun, Yan, Lin, Zhicai, Chen, Yuanyuan, Li, Zhong, Qian, Qijun, Tong, Fan, Zhang, Ruiguang, Dong, Xiaorong

“…“On-target off-tumor” toxicity is a major challenge to the use of chimeric antigen receptor (CAR)-engineered T cells in the treatment of solid malignancies,…”
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PiggyBac-Generated CAR19-T Cells Plus Lenalidomide Cause Durable Complete Remission of Triple-Hit Refractory/Relapsed DLBCL: A Case Report by Li, Chenggong, Sun, Yan, Wang, Jing, Tang, Lu, Jiang, Huiwen, Guo, Tao, Liu, Lin, Wu, Yaohui, Ai, Lisha, Xia, Linghui, Wu, Jianjun, Lin, Zhicai, Qian, Qijun, Hu, Yu, Mei, Heng

“…MYC/BCL2/BCL6 triple-hit lymphoma (THL) is an uncommon subset of high-grade B-cell lymphoma with aggressive clinical behavior and poor prognosis. TP53 mutation…”
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Triggered Immune Response Induced by Antigenic Epitopes Covalently Linked with Immunoadjuvant-Pulsed Dendritic Cells as a Promising Cancer Vaccine by Qian, Qijun, Han, Feng, Liu, Xiangzhen, Li, Qilong, Aldarouish, Mohanad, Chen, Chumeng, Liu, Hui

“…The success of peptide-based dendritic cell (DC) cancer vaccines mainly depends on the utilized peptides and selection of an appropriate adjuvant. Herein, we…”
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Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia by Tong, Yin, You, Liangshun, Liu, Hui, Li, Lu, Meng, Haitao, Qian, Qijun, Qian, Wenbin

“…An attractive strategy among adenovirus-based oncolytic systems is to design adenoviral vectors to express pro-apoptotic genes, in which this gene-virotherapy…”
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Therapeutic Mechanism of Nucleic Acid Drugs by Liu, Lianxiao, Gao, Haixia, Guo, Chuanxin, Liu, Tao, Li, Ning, Qian, Qijun

“…Abstract Nucleic acid drugs were a class of DNA/RNA molecules and considered able to be applied for protein‐related diseases treatment through regulating…”
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Scalable manufacturing methodologies for improving adeno-associated virus-based pharmaprojects by Xu Zenghui, Shi Chuanyin, Qian Qijun

“…Adeno-associated virus (AAV) is a promising viral vector and meets most requirements of being a safe biological agent. However, the commercialization of AAV…”
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Safety and Efficacy of an Immune Cell-Specific Chimeric Promoter in Regulating Anti-PD-1 Antibody Expression in CAR T Cells by Fang, Yuan, Zhang, Yajun, Guo, Chuanxin, Chen, Chumeng, Gao, Haixia, Zhou, Xiumei, Liu, Tao, Qian, Qijun

“…T cells modified to co-express cytokine or other factors with chimeric antigen receptor (CAR) can induce substantial and persistent increases in antitumor…”
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Integrated analysis of miRNA, gene, and pathway regulatory networks in hepatic cancer stem cells by Ding, Min, Li, Jiang, Yu, Yong, Liu, Hui, Yan, Zi, Wang, Jinghan, Qian, Qijun

“…Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. HCC has a poor prognosis associated with tumor recurrence and drug resistance,…”
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Use of microRNA Let-7 to control the replication specificity of oncolytic adenovirus in hepatocellular carcinoma cells by Jin, Huajun, Lv, Saiqun, Yang, Jiahe, Wang, Xiaoning, Hu, Huanzhang, Su, Changqing, Zhou, Chengliang, Li, Jiang, Huang, Yao, Li, Linfang, Liu, Xinyuan, Wu, Mengchao, Qian, Qijun

“…Highly selective therapy for hepatocellular carcinoma (HCC) remains an unmet medical need. In present study, we found that the tumor suppressor microRNA, let-7…”
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Correction: Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor by Zhang, Zhiwei, Jiang, Duqing, Yang, Huan, He, Zhou, Liu, Xiangzhen, Qin, Wenxia, Li, Linfang, Wang, Chao, Li, Yang, Li, He, Xu, Hai, Jin, Huajun, Qian, Qijun

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells by Hu, Huanzhang, Li, Zhigang, Chen, Jie, Wang, Duanming, Ma, Juming, Wang, Weiguo, Li, Jiang, Wu, Hongping, Li, Linfang, Wu, Mengchao, Qian, Qijun, Chen, Jingbo, Su, Changqing

“…Hepatocellular carcinoma (HCC) is one of the most malignant tumours with high rate of recurrence and metastasis. In HCC, deficiency of the P16/CDK4/Rb pathway…”
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hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers by Ji, Weidan, Yang, Jiahe, Wang, Duanming, Cao, Lu, Tan, Weifeng, Qian, Haihua, Sun, Bin, Qian, Qijun, Yin, Zhengfeng, Wu, Mengchao, Su, Changqing

“…Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and…”
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A novel triple-regulated oncolytic adenovirus carrying p53 gene exerts potent antitumor efficacy on common human solid cancers by Wang, Xinghua, Su, Changqing, Cao, Hui, Li, Kui, Chen, Jie, Jiang, Lixin, Zhang, Qi, Wu, Xiaobing, Jia, Xiaoyuan, Liu, Yongjing, Wang, Weiguo, Liu, Xinyuan, Wu, Mengchao, Qian, Qijun

“…Conditionally replicating adenoviruses (CRAd) can replicate specifically in cancer cells and lyse them. The CRAds were widely used in the preclinical and…”
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