Search Results - "Qi, Ziping"

Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities by Hu, Chen, Yang, Jing, Qi, Ziping, Wu, Hong, Wang, Beilei, Zou, Fengming, Mei, Husheng, Liu, Jing, Wang, Wenchao, Liu, Qingsong

“…The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both prokaryotic and eukaryotic organisms, and they maintain cellular…”
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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 by Yang, Jing, Weisberg, Ellen L., Qi, Shuang, Ni, Wei, Mei, Husheng, Wang, Zuowei, Meng, Chengcheng, Zhang, Shengzhe, Hou, Mingqi, Qi, Ziping, Wang, Aoli, Jiang, Yunyun, Jiang, Zongru, Huang, Tao, Liu, Qingwang, Magin, Robert S., Doherty, Laura, Wang, Wenchao, Liu, Jing, Buhrlage, Sara J., Liu, Qingsong, Griffin, James D.

“…Activating mutations in EZH2, the catalytic component of PRC2, promote cell proliferation, tumorigenesis, and metastasis through enzymatic or non-enzymatic…”
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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib‐induced KIT mutations in gastrointestinal stromal tumours by Liu, Juan, Gao, Jingjing, Wang, Aoli, Jiang, Zongru, Qi, Shuang, Qi, Ziping, Liu, Feiyang, Yu, Kailin, Cao, Jiangyan, Chen, Cheng, Hu, Chen, Wu, Hong, Wang, Li, Wang, Wenchao, Liu, Qingsong, Liu, Jing

“…Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumours (GISTs). While acquired on‐target mutations of…”
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Discovery of a novel and highly selective CDK9 kinase inhibitor (JSH-009) with potent antitumor efficacy in preclinical acute myeloid leukemia models by Wang, Li, Hu, Chen, Wang, Aoli, Chen, Cheng, Wu, Jiaxin, Jiang, Zongru, Zou, Fengming, Yu, Kailin, Wu, Hong, Liu, Juan, Wang, Wenliang, Wang, Zuowei, Wang, Beilei, Qi, Ziping, Liu, Qingwang, Wang, Wenchao, Li, Lili, Ge, Jian, Liu, Jing, Liu, Qingsong

“…Summary Acute myeloid leukemia (AML) is reported to be vulnerable to transcription disruption due to transcriptional addiction. Cyclin-dependent kinase 9…”
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Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia by Wang, Aoli, Hu, Chen, Chen, Cheng, Liang, Xiaofei, Wang, Beilei, Zou, Fengming, Yu, Kailin, Li, Feng, Liu, Qingwang, Qi, Ziping, Wang, Junjie, Wang, Wenliang, Wang, Li, Weisberg, Ellen L, Wang, Wenchao, Li, Lili, Ge, Jian, Xia, Ruixiang, Liu, Jing, Liu, Qingsong

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Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent by Jiang, Zongru, Wang, Li, Liu, Xuesong, Chen, Cheng, Wang, Beilei, Wang, Wenliang, Hu, Chen, Yu, Kailin, Qi, Ziping, Liu, Qingwang, Wang, Aoli, Liu, Jing, Hong, Guangchen, Wang, Wenchao, Liu, Qingsong

“…Angiogenesis is an essential process in tumor growth, invasion and metastasis. VEGF receptor 2 (VEGFR2) inhibitors targeting tumor angiogenic pathway have been…”
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Infiltrating neutrophils aggravate metabolic liver failure in fah-deficient mice by Qi, Ziping, Wang, Xin, Wei, Haiming, Sun, Rui, Tian, Zhigang

“…Background & Aims Mice deficient in tyrosine catabolic enzyme fumarylacetoacetate hydrolase (fah−/−) was a useful animal model for studying liver failure…”
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Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model by Wu, Hong, Huang, Qiong, Qi, Ziping, Chen, Yongfei, Wang, Aoli, Chen, Cheng, Liang, Qianmao, Wang, Jinghua, Chen, Wensheng, Dong, Jin, Yu, Kailin, Hu, Chen, Wang, Wenchao, Liu, Xiaochuan, Deng, Yuanxin, Wang, Li, Wang, Beilei, Li, Xiaoxiang, Gray, Nathanael S., Liu, Jing, Wei, Wei, Liu, Qingsong

“…BTK plays a critical role in the B cell receptor mediated inflammatory signaling in the rheumatoid arthritis (RA). Through a rational design approach we…”
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Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus by Wang, Junjie, Qi, Ziping, Wu, Yun, Wang, Aoli, Liu, Qingwang, Zou, Fengming, Wang, Beilei, Qi, Shuang, Cao, Jiangyan, Hu, Chen, Shi, Chenliang, Liang, Qianmao, Wang, Li, Liu, Jing, Wang, Wenchao, Liu, Qingsong

“…Insulin-producing pancreatic β cell death is the fundamental cause of type 1 diabetes (T1D) and a contributing factor to type 2 diabetes (T2D). Moreover,…”
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Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences by Wang, Aoli, Sun, Yong, Liu, Qingwang, Wu, Hong, Liu, Juan, He, Jun, Yu, Junling, Chen, Qing Qing, Ge, Yinglu, Zhang, Zhuhui, Hu, Chen, Chen, Cheng, Qi, Ziping, Zou, Fengming, Liu, Feiyang, Hu, Jie, Zhao, Ming, Huang, Tao, Wang, Beilei, Wang, Li, Wang, Wei, Wang, Wenchao, Ren, Tao, Liu, Jing, Sun, Yehuan, Fan, Song, Wu, Qibing, Liang, Chaozhao, Sun, Liangdan, Su, Bin, Wei, Wei, Liu, Qingsong

“…The global pandemic of COVID-19 has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Although currently several of clinically…”
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Discovery of a highly potent and selective Bruton’s tyrosine kinase inhibitor avoiding impairment of ADCC effects for B-cell non-Hodgkin lymphoma by Liu, Juan, Liang, Qianmao, Wang, Aoli, Zou, Fengming, Qi, Ziping, Yu, Kailin, Liu, Qingwang, Chen, Cheng, Liu, Jing, Liu, Qingsong

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Bone marrow transplantation concurrently reconstitutes donor liver and immune system across host species barrier in mice by Qi, Ziping, Li, Lu, Wang, Xuefu, Gao, Xiang, Wang, Xin, Wei, Haiming, Zhang, Jian, Sun, Rui, Tian, Zhigang

“…Liver immunopathologic mechanisms during hepatotropic infection, malignant transformation, and autoimmunity are still unclear. Establishing a chimeric mouse…”
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Discovery of a highly selective KIT kinase primary V559D mutant inhibitor for gastrointestinal stromal tumors (GISTs) by Yu, Kailin, Liu, Xuesong, Jiang, Zongru, Hu, Chen, Zou, Fengming, Chen, Cheng, Ge, Juan, Wu, Jiaxin, Liu, Xiaochuan, Wang, Aoli, Wang, Wenliang, Wang, Wenchao, Qi, Ziping, Wang, Beilei, Wang, Li, Yan, Hezhong, Wang, Jiaoxue, Ren, Tao, Tang, Jun, Liu, Qingsong, Liu, Jing

“…KIT kinase V559D mutation is the most prevalent primary gain-of-function mutation in Gastrointestinal Stromal Tumors (GISTs). Here we reported a highly…”
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Discovery of Pyrazolo1,5-apyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors by Wang, Chun, Zou, Fengming, Qi, Ziping, Liu, Qingwang, Shen, Lijuan, Yuan, Xinyu, Deng, Maoqing, Wang, Aoli, Wang, Beilei, Wang, Li, Liang, Xiaofei, Liu, Qingsong, Liu, Jing

“…PI3Kγ and PI3Kδ plays critical roles in exerting immunosuppression by targeting regulatory T cells and myeloid cells. Dual inhibition of PI3Kγ and PI3Kδ has…”
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Discovery of Pyrazolo[1,5- a ]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors by Wang, Chun, Zou, Fengming, Qi, Ziping, Liu, Qingwang, Shen, Lijuan, Yuan, Xinyu, Deng, Maoqing, Wang, Aoli, Wang, Beilei, Wang, Li, Liang, Xiaofei, Liu, Qingsong, Liu, Jing

“…PI3Kγ and PI3Kδ plays critical roles in exerting immunosuppression by targeting regulatory T cells and myeloid cells. Dual inhibition of PI3Kγ and PI3Kδ has…”
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Magnetosome-inspired synthesis of soft ferrimagnetic nanoparticles for magnetic tumor targeting by Ma, Kun, Xu, Shuai, Tao, Tongxiang, Qian, Junchao, Cui, Qiqi, Rehman, Sajid ur, Zhu, Xiaoguang, Chen, Ruiguo, Zhao, Hongxin, Wang, Changhao, Qi, Ziping, Dai, Han, Zhang, Xin, Xie, Can, Lu, Yang, Wang, Hongzhi, Wang, Junfeng

“…Magnetic targeting is one of the most promising approaches for improving the targeting efficiency by which magnetic drug carriers are directed using external…”
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Discovery of Pyrazolo[1,5-a]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor by Liang, Xiaofei, Deng, Maoqing, Zou, Fengming, Qi, Ziping, Wang, Chun, Liu, Juan, Liu, Qingwang, Wang, Beilei, Qi, Shuang, Ge, Juan, Yu, Hongwei, Wang, Aoli, Liu, Qingsong, Liu, Jing

“…Phosphoinositol 3-kinases (PI3Ks) γ and δ are primarily expressed in leukocytes and play crucial roles in regulation of the immune system. Dual inhibition of…”
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Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment by Wang, Aoli, Liu, Juan, Li, Xixiang, Zou, Fengming, Qi, Ziping, Qi, Shuang, Liu, Qingwang, Wang, Zuowei, Cao, Jiangyan, Jiang, Zongru, Wang, Beilei, Ge, Juan, Wang, Li, Wang, Wenchao, Liu, Jing, Liu, Qingsong

“…Although rat sarcoma viral oncogene homolog (RAS) mutations occur in about 30% of solid tumors, targeting RAS mutations other than KRAS-G12C is still…”
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Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Wu, Yun, Qi, Ziping, Wang, Beilei, Wang, Junjie, Liu, Qingwang, Wang, Aoli, Shi, Chenliang, Zhou, Bin, Liang, Qianmao, Wang, Wenliang, Zou, Fengming, Qi, Shuang, Wang, Zuowei, Wang, Li, Wang, Wenchao, Liu, Jing, Liu, Qingsong

“…The critical pathogenesis of type 1 diabetes (T1D)/type 2 diabetes (T2D) is the physical status, mass, and function of pancreatic β cells. Mammalian STE20-like…”
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Discovery of (S)‑2-(1-(4-Amino-3-(3-fluoro-4-methoxyphenyl)‑1H‑pyrazolo[3,4‑d]pyrimidin-1-yl)propyl)-3-cyclopropyl-5-fluoroquinazolin-4(3H)‑one (IHMT-PI3Kδ-372) as a Potent and Selective PI3Kδ Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease by Li, Feng, Liang, Xiaofei, Jiang, Zongru, Wang, Aoli, Wang, Junjie, Chen, Cheng, Wang, Wenliang, Zou, Fengming, Qi, Ziping, Liu, Qingwang, Hu, Zhenquan, Cao, Jiangyan, Wu, Hong, Wang, Beilei, Wang, Li, Liu, Jing, Liu, Qingsong

“…Accumulated pieces of evidence have shown that PI3Kδ plays a critical role in chronic obstructive pulmonary disease (COPD). Using a fragment-hybrid approach,…”
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