Search Results - "Qi, Robert Z"

A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission by Hoyer, Melissa J., Chitwood, Patrick J., Ebmeier, Christopher C., Striepen, Jonathan F., Qi, Robert Z., Old, William M., Voeltz, Gia K.

“…Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this…”
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Molecular Pathway of Microtubule Organization at the Golgi Apparatus by Wu, Jingchao, de Heus, Cecilia, Liu, Qingyang, Bouchet, Benjamin P., Noordstra, Ivar, Jiang, Kai, Hua, Shasha, Martin, Maud, Yang, Chao, Grigoriev, Ilya, Katrukha, Eugene A., Altelaar, A.F. Maarten, Hoogenraad, Casper C., Qi, Robert Z., Klumperman, Judith, Akhmanova, Anna

“…The Golgi apparatus controls the formation of non-centrosomal microtubule arrays important for Golgi organization, polarized transport, cell motility, and cell…”
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EB1 and EB3 regulate microtubule minus end organization and Golgi morphology by Yang, Chao, Wu, Jingchao, de Heus, Cecilia, Grigoriev, Ilya, Liv, Nalan, Yao, Yao, Smal, Ihor, Meijering, Erik, Klumperman, Judith, Qi, Robert Z, Akhmanova, Anna

“…End-binding proteins (EBs) are the core components of microtubule plus end tracking protein complexes, but it is currently unknown whether they are essential…”
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CDK5RAP2 is a Wnt target gene and promotes stemness and progression of oral squamous cell carcinoma by Shen, Yuehong, Chen, Yuling, Lin, Yuntao, Li, Yicun, Liu, Pengfei, Zhang, Biru, Wang, Yufan, Chan, King-Chi, Mak, Nai-Ki, Kahn, Michael, Qi, Robert Z., Yang, Hongyu

“…In oral squamous cell carcinoma (OSCC), a highly aggressive and frequently lethal malignancy, the role and action mechanism of the microtubule regulatory…”
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Whole-genome screening identifies proteins localized to distinct nuclear bodies by Fong, Ka-Wing, Li, Yujing, Wang, Wenqi, Ma, Wenbin, Li, Kunpeng, Qi, Robert Z, Liu, Dan, Songyang, Zhou, Chen, Junjie

“…The nucleus is a unique organelle that contains essential genetic materials in chromosome territories. The interchromatin space is composed of nuclear…”
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GAS2L1 Is a Centriole-Associated Protein Required for Centrosome Dynamics and Disjunction by Au, Franco K.C., Jia, Yue, Jiang, Kai, Grigoriev, Ilya, Hau, Bill K.T., Shen, Yuehong, Du, Shengwang, Akhmanova, Anna, Qi, Robert Z.

“…Mitotic spindle formation and chromosome segregation require timely separation of the two duplicated centrosomes, and this process is initiated in late G2 by…”
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The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules by Shen, Yuehong, Liu, Pengfei, Jiang, Taolue, Hu, Yu, Au, Franco K. C., Qi, Robert Z.

“…γ-Tubulin ring complexes (γTuRCs) initiate microtubule growth and mediate microtubule attachment at microtubule-organizing centers, such as centrosomes and the…”
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Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex by Wang, Zhe, Wu, Tao, Shi, Lin, Zhang, Lin, Zheng, Wei, Qu, Jianan Y., Niu, Ruifang, Qi, Robert Z.

“…As the primary microtubule-organizing centers, centrosomes require γ-tubulin for microtubule nucleation and organization. Located in close vicinity to…”
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Leptin Contributes to the Adaptive Responses of Mice to High-Fat Diet Intake through Suppressing the Lipogenic Pathway by Jiang, Lei, Wang, Qiong, Yu, Yue, Zhao, Feng, Huang, Ping, Zeng, Rong, Qi, Robert Z, Li, Wenjun, Liu, Yong

“…Background: Leptin is an adipocyte-derived hormone that plays a critical role in energy homeostasis and lipid metabolism. Overnutrition-associated obesity is…”
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A Combined Proteomics and Metabolomics Profiling of Gastric Cardia Cancer Reveals Characteristic Dysregulations in Glucose Metabolism by Cai, Zhen, Zhao, Jiang-Sha, Li, Jing-Jing, Peng, Dan-Ni, Wang, Xiao-Yan, Chen, Tian-Lu, Qiu, Yun-Ping, Chen, Ping-Ping, Li, Wen-Jie, Xu, Li-Yan, Li, En-Ming, Tam, Jason P.M., Qi, Robert Z., Jia, Wei, Xie, Dong

“…Gastric cardia cancer (GCC), which occurs at the gastric-esophageal boundary, is one of the most malignant tumors. Despite its high mortality and morbidity,…”
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Anxa2 Plays a Critical Role in Enhanced Invasiveness of the Multidrug Resistant Human Breast Cancer Cells by Zhang, Fei, Zhang, Lin, Zhang, Bin, Wei, Xiyin, Yang, Yi, Qi, Robert Z, Ying, Guoguang, Zhang, Ning, Niu, Ruifang

“…Multidrug resistance (MDR) is the major cause of failure in cancer chemotherapy. Recent reports even suggest that MDR is associated with elevated invasion and…”
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Regulation and Function of Protein Kinases and Phosphatases by Cheng, Heung-Chin, Qi, Robert Z., Paudel, Hemant, Zhu, Hong-Jian

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Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum by Zhang, Chao, Kho, Yik-Shing, Wang, Zhe, Chiang, Yan Ting, Ng, Gary K H, Shaw, Pang-Chui, Wang, Yuzhuo, Qi, Robert Z

“…The endoplasmic reticulum (ER) is a continuous membrane network in eukaryotic cells comprising the nuclear envelope, the rough ER, and the smooth ER. The ER…”
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Protocol to measure inter-centrosome distance in adherent cells using epifluorescence microscopy by Au, Franco K.C., Lui, Edna S.W., Qi, Robert Z.

“…We present here a protocol to assay the centrosome separation events at late-G2 phase of the cell cycle by immunofluorescence microscopy. We describe the steps…”
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Apicosome: Newly identified cell-type-specific organelle in mouse cochlear and vestibular hair cells by Li, Xiaofen, Zhao, Qirui, Yu, Xiaojie, Cao, Wenhan, Zhang, Yingyi, Feng, Wanying, Jiang, Liwen, He, David Z., Qi, Robert Z., Huang, Pingbo

“…Cochlear and vestibular hair cells are highly specialized sensory receptors for hearing and balance. Here, we report a serendipitous identification of a…”
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Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine by Song, Yongcheng, Kesuma, Djohan, Wang, Jian, Deng, Yu, Duan, Jinao, Wang, Jerry H, Qi, Robert Z

“…As key regulators of the cell proliferation cycle, cyclin-dependent kinases (CDKs) are attractive targets for the development of anti-tumor drugs. In the…”
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Dynamic recruitment of CDK5RAP2 to centrosomes requires its association with dynein by Jia, Yue, Fong, Ka-Wing, Choi, Yuk-Kwan, See, Siu-San, Qi, Robert Z

“…CDK5RAP2 is a centrosomal protein known to be involved in the regulation of the γ-tubulin ring complex and thus the organization of microtubule arrays…”
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Calmodulin Binding and Cdk5 Phosphorylation of p35 Regulate Its Effect on Microtubules by He, Lisheng, Hou, Zhibo, Qi, Robert Z.

“…In the nervous system, Cdk5 and its neuronal activator p35 are involved in the control of various activities, including neuronal differentiation and migration…”
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Identification of Nuclear Import Mechanisms for the Neuronal Cdk5 Activator by Fu, Xinrong, Choi, Yuk-Kwan, Qu, Dianbo, Yu, Yan, Cheung, Nam Sang, Qi, Robert Z.

“…The activation of Cdk5 by p35 plays a pivotal role in a multitude of nervous system activities ranging from neuronal differentiation to degeneration. A…”
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Regulation of S6 Kinase 1 Activation by Phosphorylation at Ser-411 by Hou, Zhibo, He, Lisheng, Qi, Robert Z.

“…Ribosomal S6 kinase 1 (S6K1), as a key regulator of mRNA translation, plays an important role in cell cycle progression through the G1 phase of proliferating…”
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