Search Results - "Qi, Hank H."

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases by Cheng, Xiaodong, Horton, John R, Upadhyay, Anup K, Qi, Hank H, Zhang, Xing, Shi, Yang

“…The jumonji domain demethylases catalyze demethylation of histones, thus affecting modifications that are associated with transcription status. Structural and…”
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Hypoxia Potentiates MicroRNA-Mediated Gene Silencing through Posttranslational Modification of Argonaute2 by Wu, Connie, So, Jessica, Davis-Dusenbery, Brandi N., Qi, Hank H., Bloch, Donald B., Shi, Yang, Lagna, Giorgio, Hata, Akiko

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins by Wang, Bingbing, Li, Shuqiang, Novina, Carl D, Qi, Hank H, Chowdhury, Dipanjan, Shi, Yang

“…Argonaute family members are effectors in small RNA-mediated silencing. In vitro analysis of the four human Argonautes demonstrates that AGO1 and AGO2 mediate…”
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Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance by Liu, Qi, Borcherding, Nicholas C., Shao, Peng, Maina, Peterson K., Zhang, Weizhou, Qi, Hank H.

“…HER2 plays a critical role in tumourigenesis and is associated with poor prognosis of patients with HER2-positive breast cancers. Although anti-HER2 drugs are…”
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Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity by Xing, Shaojun, Li, Fengyin, Zeng, Zhouhao, Zhao, Yunjie, Yu, Shuyang, Shan, Qiang, Li, Yalan, Phillips, Farrah C, Maina, Peterson K, Qi, Hank H, Liu, Chengyu, Zhu, Jun, Pope, R Marshall, Musselman, Catherine A, Zeng, Chen, Peng, Weiqun, Xue, Hai-Hui

“…Xue and colleagues show that the transcription factors Tcf1 and Lef1 suppress CD4 + T lineage genes in CD8 + T cells through intrinsic histone deacetylase…”
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Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage by Ongusaha, Pat P, Qi, Hank H, Raj, Lakshmi, Kim, Young-Bum, Aaronson, Stuart A, Davis, Roger J, Shi, Yang, Liao, James K, Lee, Sam W

“…Although apoptosis triggered by ultraviolet B (UVB)-mediated activation of the c-Jun N-terminal kinase (JNK) pathway is mediated by both intrinsic and…”
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The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases by Iwase, Shigeki, Lan, Fei, Bayliss, Peter, de la Torre-Ubieta, Luis, Huarte, Maite, Qi, Hank H., Whetstine, Johnathan R., Bonni, Azad, Roberts, Thomas M., Shi, Yang

“…Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is…”
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Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development by Roberts, Thomas M, Shi, Yang, Qi, Hank H, Sarkissian, Madathia, Hu, Gang-Qing, Wang, Zhibin, Bhattacharjee, Arindam, Gordon, D. Benjamin, Gonzales, Michelle, Lan, Fei, Ongusaha, Pat P, Huarte, Maite, Yaghi, Nasser K, Lim, Huijun, Garcia, Benjamin A, Brizuela, Leonardo, Zhao, Keji

“…X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability. Causal mutations have been found in approximately 90…”
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A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair by Gay, Frédérique, Landry, Joseph, Liu, Huifei, Shi, Yujiang, Wu, Su, Wang, Weijia, Shi, Yang, Mulligan, Peter, Wu, Carl, Qi, Hank H, Lu, Ju, Nickoloff, Jac A

“…DNA damage repair is crucial for the maintenance of genome integrity and cancer suppression. We found that loss of the mouse transcription factor YY1 resulted…”
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Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling by Kluz, Paige N., Kolb, Ryan, Xie, Qing, Borcherding, Nicholas, Liu, Qi, Luo, Yuewan, Kim, Myung-Chul, Wang, Linna, Zhang, Yinan, Li, Wei, Stipp, Christopher, Gibson-Corley, Katherine N., Zhao, Chen, Qi, Hank H., Bellizzi, Andrew, Tao, Andy W., Sugg, Sonia, Weigel, Ronald J., Zhou, Daohong, Shen, Xian, Zhang, Weizhou

“…Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 ( CD177 ), a known neutrophil…”
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eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference by Yi, Tingfang, Arthanari, Haribabu, Akabayov, Barak, Song, Huaidong, Papadopoulos, Evangelos, Qi, Hank H., Jedrychowski, Mark, Güttler, Thomas, Guo, Cuicui, Luna, Rafael E., Gygi, Steven P., Huang, Stephen A., Wagner, Gerhard

“…MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation…”
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Prolyl 4-hydroxylation regulates Argonaute 2 stability by Lee, Sam W, Shi, Yang, Ongusaha, Pat P, Shi, Yujiang, Peng, Junmin, Qi, Hank H, Pakkanen, Outi, Cheng, Dongmei, Myllyharju, Johanna

“…Human Argonaute (Ago) proteins are essential components of the RNA-induced silencing complexes (RISCs). Argonaute 2 (Ago2) has a P-element-induced wimpy testis…”
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Tcf1 and Lef1 transcription factors establish CD8 super(+) T cell identity through intrinsic HDAC activity by Xing, Shaojun, Li, Fengyin, Zeng, Zhouhao, Zhao, Yunjie, Yu, Shuyang, Shan, Qiang, Li, Yalan, Phillips, Farrah C, Maina, Peterson K, Qi, Hank H, Liu, Chengyu, Zhu, Jun, Pope, R Marshall, Musselman, Catherine A, Zeng, Chen, Peng, Weiqun, Xue, Hai-Hui

“…The CD4 super(+) and CD8 super(+) T cell dichotomy is essential for effective cellular immunity. How individual T cell identity is established remains poorly…”
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Tcfl and Lef1 transcription factors establish [CD8.sup.+] T cell identity through intrinsic HDAC activity by Xing, Shaojun, Li, Fengyin, Zeng, Zhouhao, Zhao, Yunjie, Yu, Shuyang, Shan, Qiang, Li, Yalan, Phillips, Farrah C, Maina, Peterson K, Qi, Hank H, Liu, Chengyu, Zhu, Jun, Pope, R.Marshall, Musselman, Catherine A, Zeng, Chen, Peng, Weiqun, Xue, Hai-Hui

“…The [CD4.sup.+] and [CD8.sup.+] T cell dichotomy is essential for effective cellular immunity. How individual T cell identity is established remains poorly…”
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Akt-mediated phosphorylation of Argonaute 2 down-regulates cleavage and up-regulates translational repression of microRNA targets by Horman, Shane R., Janas, Maja M., Litterst, Claudia, Wang, Bingbing, MacRae, Ian J., Sever, Mary J., Morrissey, David V., Graves, Paul, Luo, Biao, Umesalma, Shaikamjad, Qi, Hank H., Miraglia, Loren J., Novina, Carl D., Orth, Anthony P.

“…A high-throughput RNA interference (RNAi) screen targeting 542 genes of the human kinome was used to discover regulators of RNAi. Here we report that the…”
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The XLMR gene PHF8 encodes a histone H4K20/H3K9 demethylase and regulates zebrafish brain and craniofacial development by Qi, Hank H., Sarkissian, Madathia, Hu, Gang-Qing, Wang, Zhibin, Bhattacharjee, Arindam, Gordon, D. Benjamin, Gonzales, Michelle, Lan, Fei, Ongusaha, Pat P., Huarte, Maite, Yaghi, Nasser K., Lim, Huijun, Garcia, Benjamin A., Brizuela, Leonardo, Zhao, Keji, Roberts, Thomas M., Shi, Yang

“…X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability 1 . Causal mutations have been found in approximately 90…”
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