Integrative treatment of anti-tumor/bone repair by combination of MoS2 nanosheets with 3D printed bioactive borosilicate glass scaffolds

[Display omitted] •“Integrative treatment” anti-tumor/bone repair BGM scaffolds were fabricated.•BGM can retain MoS2 for >60 days implying its’ photothermal ability.•BGM can reduce MNNG/HOS viability and inhibit tumor growth in vitro and in vivo.•BGM stimulate differentiation of rBMSCs, upregulat...

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Bibliographic Details
Published in:	Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 396; p. 125081
Main Authors:	Wang, Hui, Zeng, Xiangqiong, Pang, Libin, Wang, Haihang, Lin, Bocai, Deng, Zhengwei, Qi, Edwina Lau Xiu, Miao, Na, Wang, Deping, Huang, Peng, Hu, Haoran, Li, Jiusheng
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-09-2020
Subjects:	Anti-tumor Bioactive borosilicate glass Bone repair Integrative treatment Photothermal MoS2 Integrative treatment Bone repair Anti-tumor Bioactive borosilicate glass Photothermal MoS2
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Summary:	[Display omitted] •“Integrative treatment” anti-tumor/bone repair BGM scaffolds were fabricated.•BGM can retain MoS2 for >60 days implying its’ photothermal ability.•BGM can reduce MNNG/HOS viability and inhibit tumor growth in vitro and in vivo.•BGM stimulate differentiation of rBMSCs, upregulate osteogenetic genes expression.•The BGM scaffolds can promote bone tissues repairing in rat calvarial defects. Malignant bone tumors have caused great obstacles and serious illnesses for tumor recurrence and difficulty in reconstructing and repairing large defects after tumorectomy. Additionally, long-term efficacy, satisfactory biocompatibility and excellent properties for anti-tumor agents are necessary in the biomedical field. To solve these problems, a novel idea has been proposed on building an integrative anti-tumor/bone repairing scaffold by covering photothermal therapy (PTT) composite MoS2-PLGA film on the surface of borosilicate bioactive glass (BG). In our study, the MoS2-integrated composite BG (BGM) scaffolds can rapidly and effectively elevate temperature, and they exhibited excellent photothermal stability, under 808 nm laser irradiation. Notably, the BGM scaffolds can effectively reduce the viability of osteosarcoma cells (MNNG/HOS) in vitro as well as inhibit the tumor growth in nude mice. Furthermore, the prepared BGM scaffolds can stimulate the proliferation and differentiation of rat bone mesenchymal stem cells (rBMSCs), upregulate the expression of osteogenesis-related genes (Runx-2, OCN and Col-I) in vitro and promote in vivo bone repair in critical-sized rat calvarial defects. Therefore, the novel MoS2-integrated composite BG scaffolds are highly promising for the treatment of tumor-related bone defects, offering ideas for the manufacture of new materials in the tissue engineering field.
ISSN:	1385-8947 1873-3212
DOI:	10.1016/j.cej.2020.125081