Search Results - "Qazi, Maleeha A."

Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma by Qazi, Maleeha A, Vora, Parvez, Venugopal, Chitra, Adams, Jarrett, Singh, Mohini, Hu, Amy, Gorelik, Maryna, Subapanditha, Minomi K, Savage, Neil, Yang, Jiahe, Chokshi, Chirayu, London, Max, Gont, Alexander, Bobrowski, David, Grinshtein, Natalie, Brown, Kevin R, Murty, Naresh K, Nilvebrant, Johan, Kaplan, David, Moffat, Jason, Sidhu, Sachdev, Singh, Sheila K

“…Glioblastoma (GBM) carries a dismal prognosis and inevitably relapses despite aggressive therapy. Many members of the Eph receptor tyrosine kinase (EphR)…”
Get full text

Pyrvinium Targets CD133 in Human Glioblastoma Brain Tumor-Initiating Cells by Venugopal, Chitra, Hallett, Robin, Vora, Parvez, Manoranjan, Branavan, Mahendram, Sujeivan, Qazi, Maleeha A, McFarlane, Nicole, Subapanditha, Minomi, Nolte, Sara M, Singh, Mohini, Bakhshinyan, David, Garg, Neha, Vijayakumar, Thusyanth, Lach, Boleslaw, Provias, John P, Reddy, Kesava, Murty, Naresh K, Doble, Bradley W, Bhatia, Mickie, Hassell, John A, Singh, Sheila K

“…Clonal evolution of cancer may be regulated by determinants of stemness, specifically self-renewal, and current therapies have not considered how genetic…”
Get full text

Childhood cerebellar tumours mirror conserved fetal transcriptional programs by Vladoiu, Maria C., El-Hamamy, Ibrahim, Donovan, Laura K., Farooq, Hamza, Holgado, Borja L., Sundaravadanam, Yogi, Ramaswamy, Vijay, Hendrikse, Liam D., Kumar, Sachin, Mack, Stephen C., Lee, John J. Y., Fong, Vernon, Juraschka, Kyle, Przelicki, David, Michealraj, Antony, Skowron, Patryk, Luu, Betty, Suzuki, Hiromichi, Morrissy, A. Sorana, Cavalli, Florence M. G., Garzia, Livia, Daniels, Craig, Wu, Xiaochong, Qazi, Maleeha A., Singh, Sheila K., Chan, Jennifer A., Marra, Marco A., Malkin, David, Dirks, Peter, Heisler, Lawrence, Pugh, Trevor, Ng, Karen, Notta, Faiyaz, Thompson, Eric M., Kleinman, Claudia L., Joyner, Alexandra L., Jabado, Nada, Stein, Lincoln, Taylor, Michael D.

“…Study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course…”
Get full text

Deciphering brain tumor heterogeneity, one cell at a time by Qazi, Maleeha A., Bakhshinyan, David, Singh, Sheila K.

“…Single-cell RNA sequencing characterizes clonal dynamics and distinct cellular states contributing to intratumoral heterogeneity in glioblastoma and…”
Get full text

Bmi1 regulates human glioblastoma stem cells through activation of differential gene networks in CD133+ brain tumor initiating cells by Vora, Parvez, Seyfrid, Mathieu, Venugopal, Chitra, Qazi, Maleeha A., Salim, Sabra, Isserlin, Ruth, Subapanditha, Minomi, O’Farrell, Erin, Mahendram, Sujeivan, Singh, Mohini, Bakhshinyan, David, Chokshi, Chirayu, McFarlane, Nicole, Dvorkin-Gheva, Anna, Brown, Kevin R., Murty, Naresh, Moffat, Jason, Bader, Gary D., Singh, Sheila K.

“…Purpose Glioblastoma (GBM) is the most aggressive adult brain cancer, with a 15 month median survivorship attributed to the existence of treatment-refractory…”
Get full text

Introduction to Cancer Stem Cells: Past, Present, and Future by Bakhshinyan, David, Adile, Ashley A, Qazi, Maleeha A, Singh, Mohini, Kameda-Smith, Michelle M, Yelle, Nick, Chokshi, Chirayu, Venugopal, Chitra, Singh, Sheila K

“…The Cancer Stem Cell (CSC) hypothesis postulates the existence of a small population of cancer cells with intrinsic properties allowing for resistance to…”
Get more information

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma by Qazi, Maleeha A., Salim, Sabra K., Brown, Kevin R., Mikolajewicz, Nicholas, Savage, Neil, Han, Hong, Subapanditha, Minomi K., Bakhshinyan, David, Nixon, Allison, Vora, Parvez, Desmond, Kimberly, Chokshi, Chirayu, Singh, Mohini, Khoo, Amanda, Macklin, Andrew, Khan, Shahbaz, Tatari, Nazanin, Winegarden, Neil, Richards, Laura, Pugh, Trevor, Bock, Nicholas, Mansouri, Alireza, Venugopal, Chitra, Kislinger, Thomas, Goyal, Sidhartha, Moffat, Jason, Singh, Sheila K.

“…Recurrence of solid tumors renders patients vulnerable to advanced, treatment-refractory disease state with mutational and oncogenic landscape distinctive from…”
Get full text

PD-L1 expression in breast cancer brain metastases by Chehade, Rania, Qazi, Maleeha A, Ennis, Marguerite, Sahgal, Arjun, Das, Sunit, Nofech-Mozes, Sharon, Jerzak, Katarzyna J

“…BackgroundTo evaluate the potential intracranial efficacy of immunotherapy among patients with breast cancer brain metastases (BrM), we analyzed the…”
Get full text

A novel stem cell culture model of recurrent glioblastoma by Qazi, Maleeha A., Vora, Parvez, Venugopal, Chitra, McFarlane, Nicole, Subapanditha, Minomi K., Murty, Naresh K., Hassell, John A., Hallett, Robin M., Singh, Sheila K.

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults with average disease relapse at 9 months and median survival rarely…”
Get full text

Identification of five important genes to predict glioblastoma subtypes by Tang, Yang, Qazi, Maleeha A, Brown, Kevin R, Mikolajewicz, Nicholas, Moffat, Jason, Singh, Sheila K, McNicholas, Paul D

“…Glioblastoma (GBM), the most common and aggressive primary brain tumour in adults, has been classified into three subtypes: classical, mesenchymal, and…”
Get full text

Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence by Bakhshinyan, David, Adile, Ashley A, Liu, Jeff, Gwynne, William D, Suk, Yujin, Custers, Stefan, Burns, Ian, Singh, Mohini, McFarlane, Nicole, Subapanditha, Minomi K, Qazi, Maleeha A, Vora, Parvez, Kameda-Smith, Michelle M, Savage, Neil, Desmond, Kim L, Tatari, Nazanin, Tran, Damian, Seyfrid, Mathieu, Hope, Kristin, Bock, Nicholas A, Venugopal, Chitra, Bader, Gary D, Singh, Sheila K

“…Medulloblastoma (MB) remains a leading cause of cancer-related mortality among children. The paucity of MB samples collected at relapse has hindered the…”
Get full text

Abstract P5-13-17: PD-L1 expression in breast to brain metastases by Chehade, Rania, Qazi, Maleeha A, Ennis, Marguerite, Nofech-Mozes, Sharon, Jerzak, Katarzyna

“…Background Brain metastases (BrM) are a major cause of morbidity and mortality in women with breast cancer. Immunotherapy has the potential for intracranial…”
Get full text

EXPRESSION OF ANDROGEN RECEPTOR IN BREAST CANCER BRAIN METASTASES by Fan, Kevin Yijun, Chehade, Rania, Qazi, Maleeha A, Moravan, Veronika, Nofech-Moses, Sharon, Jerzak, Katarzyna J

“…Given availability of central nervous system (CNS)-penetrant systemic therapies that target the androgen receptor (AR), we evaluated the expression of the AR…”
Get full text

EMBR-22. RATIONAL DEVELOPMENT OF SYNERGISTIC THERAPIES ALONGSIDE BMI1 INHIBITION FOR GROUP 3 MEDULLOBLASTOMA by Bakhshinyan, David, Adile, Ashley A, Venugopal, Chitra, Brown, Kevin, Chan, Katherine, Qazi, Maleeha A, Chokshi, Chirayu, Gwynne, William D, Tieu, David, Moffat, Jason, Singh, Sheila

“…Medulloblastoma (MB) is the most common pediatric brain tumor. Of its four distinct molecular subgroups, Group 3 MBs are associated with increased risk of…”
Get full text

Abstract 1911: Uncovering novel targets of recurrent glioblastoma using transcriptomic profiling in a patient-derived xenograft model by Yelle, Nicolas, Chokshi, Chirayu, Vora, Parvez, Brown, Kevin R., Qazi, Maleeha A., Singh, Mohini, Adams, Jarrett J., Venugopal, Chitra, Sidhu, Sachdev, Moffat, Jason, Singh, Sheila K.

“…Glioblastoma (GBM) is the most common and aggressive adult primary brain tumor feared for its near uniformly fatal prognosis despite advances in multimodal…”
Get full text