Search Results - "QUNSHENG JI"

Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer by Teng, Shuaishuai, Li, Yang Eric, Yang, Ming, Qi, Rui, Huang, Yiming, Wang, Qianyu, Zhang, Yanmei, Chen, Shanwen, Li, Shasha, Lin, Kequan, Cao, Yang, Ji, Qunsheng, Gu, Qingyang, Cheng, Yujing, Chang, Zai, Guo, Wei, Wang, Pengyuan, Garcia-Bassets, Ivan, Lu, Zhi John, Wang, Dong

“…Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is…”
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FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547 by LIANG XIE, XINYING SU, BEIRONG GAO, DANPING SHEN, LIANHAI ZHANG, JIAFU JI, GAVINE, Paul R, JINGCHUAN ZHANG, KILGOUR, Elaine, XIAOLIN ZHANG, QUNSHENG JI, LIN ZHANG, XIAOLU YIN, LILI TANG, XIUHUA ZHANG, YANPING XU, ZEREN GAO, KUNJI LIU, MINHUA ZHOU

“…FGFR gene aberrations are associated with tumor growth and survival. We explored the role of FGFR2 amplification in gastric cancer and the therapeutic…”
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Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non―Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models by JINGCHUAN ZHANG, LIN ZHANG, ZHENGWEI DONG, GUANSHAN ZHU, ZILIANG QIAN, LILI TANG, PING ZHAN, QUNSHENG JI, KILGOUR, Elaine, SMITH, Paul D, NIGEL BROOKS, A, THOMAS, Roman K, XINYING SU, GAVINE, Paul R, MING LI, LIANG XIE, MALCHERS, Florian, SHUQIONG FAN, XIAOLU YIN, YANPING XU, KUNJI LIU

“…To investigate the incidence of FGFR1 amplification in Chinese non-small cell lung cancer (NSCLC) and to preclinically test the hypothesis that the novel,…”
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Antitumor effects of regorafenib and sorafenib in preclinical models of hepatocellular carcinoma by Kissel, Maria, Berndt, Sandra, Fiebig, Lukas, Kling, Simon, Ji, Qunsheng, Gu, Qingyang, Lang, Tina, Hafner, Frank-Thorsten, Teufel, Michael, Zopf, Dieter

“…The purpose of this study was to investigate the antitumor activity of regorafenib and sorafenib in preclinical models of HCC and to assess their mechanism of…”
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Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma by Dong, Hua, Zhang, Lan, Qian, Ziliang, Zhu, Xuehua, Zhu, Guanshan, Chen, Yunqin, Xie, Xiaoying, Ye, Qinghai, Zang, Jie, Ren, Zhenggang, Ji, Qunsheng

“…To gain molecular insights of HBV integration that may contribute to HCC tumorigenesis, we performed whole transcriptome sequencing and whole genome copy…”
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Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets by Qian, Ziliang, Zhu, Guanshan, Tang, Lili, Wang, Mei, Zhang, Lianhai, Fu, Jiangang, Huang, Chunlei, Fan, Shuqiong, Sun, Yun, Lv, Jing, Dong, Hua, Gao, Beirong, Su, Xinying, Yu, Dehua, Zang, Jie, Zhang, Xiaolin, Ji, Jiafu, Ji, Qunsheng

“…Gastric cancer is the second leading cause of death from cancer worldwide, with an approximately 20% 5‐year survival rate. To identify molecular subtypes…”
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Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer by Wang, Xiaohong, Liu, Yiqiang, Shao, Duanfang, Qian, Ziliang, Dong, Zhengwei, Sun, Yun, Xing, Xiaofang, Cheng, Xiaojing, Du, Hong, Hu, Ying, Li, Yingai, Li, Lin, Dong, Bin, Li, Ziyu, Wu, Aiwen, Wu, Xiaojiang, Bu, Zhaode, Zong, Xianglong, Zhu, Guanshan, Ji, Qunsheng, Wen, Xian-zi, Zhang, Lian-hai, Ji, Jia-fu

“…Background Gastric cancer (GC) is an aggressive malignancy whose mechanisms of development and progression are poorly understood. The identification of…”
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Prognostic value of a 25-gene assay in patients with gastric cancer after curative resection by Wang, Xiaohong, Liu, Yiqiang, Niu, Zhaojian, Fu, Runjia, Jia, Yongning, Zhang, Li, Shao, Duanfang, Du, Hong, Hu, Ying, Xing, Xiaofang, Cheng, Xiaojing, Li, Lin, Guo, Ting, Li, Ziyu, Ji, Qunsheng, Zhang, Lianhai, Ji, Jiafu

“…This study aimed to develop and validate a practical, reliable assay for prognosis and chemotherapy benefit prediction compared with conventional staging in…”
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Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models by Wu, Xianhua, Zhang, Jingchuan, Zhen, Ruheng, Lv, Jing, Zheng, Li, Su, Xinying, Zhu, Guanshan, Gavine, Paul R, Xu, Songtao, Lu, Shaohua, Hou, Jun, Liu, Yalan, Xu, Chen, Tan, Yunshan, Xie, Liang, Yin, Xiaolu, He, Deming, Ji, Qunsheng, Hou, Yingyong, Ge, Di

“…Trastuzumab is currently approved for the clinical treatment of breast and gastric cancer patients with HER-2 positive tumors, but not yet for the treatment of…”
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An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma by Zhang, Tianwei, Lu, Yachao, Ye, Qingqing, Zhang, Meizhuo, Zheng, Li, Yin, Xiaolu, Gavine, Paul, Sun, Zhongsheng, Ji, Qunsheng, Zhu, Guanshan, Su, Xinying

“…To recommend a reliable and clinically realistic RET/PTC rearrangement detection assay for papillary thyroid carcinoma (PTC), we compared multiplex…”
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Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis by Kikani, Chintan K, Verona, Erik V, Ryu, Jiyoon, Shen, Yanying, Ye, Qingqing, Zheng, Li, Qian, Ziliang, Sakaue, Hiroshi, Nakamura, Kyoko, Du, Jie, Ji, Qunsheng, Ogawa, Wataru, Sun, Lu-Zhe, Dong, Lily Q, Liu, Feng

“…Enhanced activation of phosphoinositide 3-kinase (PI3K) is a hallmark of many human tumors because it promotes cell proliferation and survival through several…”
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The oncogenic role of PKCiota gene amplification and overexpression in Chinese non-small cell lung cancer by Luo, Qingquan, Tang, Lili, Lin, Hao, Huang, Jia, Zhang, Tianwei, Liu, Yuanjie, Wang, Jia, Zhan, Ping, Yin, Xiaolu, Su, Xinying, Ji, Qunsheng, Yu, Dehua, Xu, Lin

“…Abstract Background The atypical protein kinase C isozyme iota (PKCiota) has been proposed as an oncogene based on its transformation property and…”
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Genomic and transcriptome profiling identified both human and HBV genetic variations and their interactions in Chinese hepatocellular carcinoma by Dong, Hua, Qian, Ziliang, Zhang, Lan, Chen, Yunqin, Ren, Zhenggang, Ji, Qunsheng

“…Interaction between HBV and host genome integrations in hepatocellular carcinoma (HCC) development is a complex process and the mechanism is still unclear…”
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Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy by Jin, Meizhong, Kleinberg, Andrew, Cooke, Andy, Gokhale, Prafulla C., Foreman, Kenneth, Dong, Hanqing, Siu, Kam W., Bittner, Mark A., Mulvihill, Kristen M., Yao, Yan, Landfair, Darla, O’Connor, Matthew, Mak, Gilda, Pachter, Jonathan A., Wild, Robert, Rosenfeld-Franklin, Maryland, Ji, Qunsheng, Mulvihill, Mark J.

“…Preclinical and emerging clinical evidence suggests that inhibiting insulin-like growth factor 1 receptor (IGF-1R) signaling may offer a promising therapeutic…”
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Polydactyly and ectopic ZPA formation in Alx-4 mutant mice by Qu, S, Niswender, K D, Ji, Q, van der Meer, R, Keeney, D, Magnuson, M A, Wisdom, R

“…Correct development of the limb is dependent on coordination between three distinct signaling centers. Recently, fibroblast growth factor-4 has been identified…”
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DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy by Sun, Lele, Shen, Fengyun, Xiong, Zijian, Yang, He, Dong, Ziliang, Xiang, Jian, Gu, Qingyang, Ji, Qunsheng, Fan, Chunhai, Liu, Zhuang

“…Artificial antigen-presenting cells (aAPCs) constructed by integrating T cell activation ligands on biocompatible materials hold great potential in tumor…”
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Abstract 2959: Establishment of KRAS-G12C inhibitor induced resistant tumor models enable the development of new generation KRAS-G12C inhibitors and combinatorial strategies by Liu, Gaoxiang, Shi, Wenting, Gu, Qingyang, Ji, Qunsheng

“…Abstract The KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) gene is one of the most popular oncogenes in the recent targeted therapy research…”
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Abstract 1118: Engineered cell line panel complemented with in vivo models to enable next-generation target therapy discovery in cancer by Zhang, Zhixiang, Shi, Xiaohe, Zuo, Xiangyang, Gu, Qingyang, Ji, Qunsheng

“…Abstract Many cancer types are driven by specific gene aberrances, like gene fusions, mutations and copy number changes. It has led to the successful…”
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The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies by Liu, Xiaoqing, Lu, Yachao, Zhu, Guanshan, Lei, Yao, Zheng, Li, Qin, Haifeng, Tang, Chuanhao, Ellison, Gillian, McCormack, Rose, Ji, Qunsheng

“…To evaluate the suitability of malignant pleural effusion (MPE) and plasma as surrogate samples for epidermal growth factor receptor (EGFR) mutation detection,…”
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Cathepsin S-mediated autophagic flux in tumor-associated macrophages accelerate tumor development by promoting M2 polarization by Yang, Min, Liu, Jingwei, Shao, Jianghua, Qin, Yanwen, Ji, Qunsheng, Zhang, Xiaolin, Du, Jie

“…Tumor-associated macrophages (TAMs) are the major component of tumor-infiltrating leukocytes. TAMs are heterogeneous, with distinct phenotypes influenced by…”
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