Search Results - "QUINTAS, Luis Eduardo M"

Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study by Azalim, Pedro, do Monte, Fernando M., Rendeiro, Mariana Manzano, Liu, Xiaofan, O'Doherty, George A., Fontes, Carlos Frederico, Leitão, Suzana Guimarães, Quintas, Luis Eduardo M., Noël, François

“…[Display omitted] There is a renewed interest in the Na+/K+-ATPase (NKA, EC 3.6.3.9) either as a target for new therapeutic uses or for understanding the…”
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Implications of Synthetic Modifications of the Cardiotonic Steroid Lactone Ring on Cytotoxicity by de Oliveira, Gisele Capanema, Rocha, Sayonarah Carvalho, da Silva Lopes, Miliane Alves, Paixão, Natasha, Alves, Silmara Lúcia Grego, Pessoa, Marco Túlio Corrêa, Noël, François, Quintas, Luis Eduardo M., Barbosa, Leandro Augusto, Villar, José Augusto Ferreira Perez, Cortes, Vanessa Faria

“…Na,K-ATPase (NKA) and cardiotonic steroids (CTS) have shown potent cytotoxic and anticancer effects. Here, we have synthesized a series of CTS digoxin…”
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Telocinobufagin and Marinobufagin Produce Different Effects in LLC-PK1 Cells: A Case of Functional Selectivity of Bufadienolides by Amaral, Luciana S, Martins Ferreira, Jainne, Predes, Danilo, Abreu, José Garcia, Noël, François, Quintas, Luis Eduardo M

“…Bufadienolides are cardiotonic steroids (CTS) identified in mammals. Besides Na⁺/K⁺-ATPase inhibition, they activate signal transduction via protein⁻protein…”
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Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): Inhibition of human kidney Na+/K+-ATPase activity by Perera Córdova, Wilmer H., Leitão, Suzana Guimarães, Cunha-Filho, Geraldino, Bosch, Roberto Alonso, Alonso, Isel Pascual, Pereda-Miranda, Rogelio, Gervou, Rodrigo, Touza, Natália Araújo, Quintas, Luis Eduardo M., Noël, François

“…Parotoid gland secretions of toad species are a vast reservoir of bioactive molecules with a wide range of biological properties. Herein, for the first time,…”
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Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase by Cai, Ting, Wang, Haojie, Chen, Yiliang, Liu, Lijun, Gunning, William T, Quintas, Luis Eduardo M, Xie, Zi-Jian

“…Here, we show that the Na/K-ATPase interacts with caveolin-1 (Cav1) and regulates Cav1 trafficking. Graded knockdown of Na/K-ATPase decreases the plasma…”
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Effect of ouabain on calcium signaling in rodent brain: A systematic review of in vitro studies by Leite, Jacqueline Alves, Pôças, Elisa, Maia, Gisele Silva, Barbosa, Leandro, Quintas, Luis Eduardo M., Kawamoto, Elisa Mitiko, Silva, Maria Luiza Correia da, Scavone, Cristoforo, de Carvalho, Luciana E. Drumond

“…The Na + /K + -ATPase is an integral membrane ion pump, essential to maintaining osmotic balance in cells in the presence of cardiotonic steroids; more…”
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A Novel Apilic Antivenom to Treat Massive, Africanized Honeybee Attacks: A Preclinical Study from the Lethality to Some Biochemical and Pharmacological Activities Neutralization by Teixeira-Cruz, Jhonatha Mota, Strauch, Marcelo Abrahão, Monteiro-Machado, Marcos, Tavares-Henriques, Matheus Silva, de Moraes, João Alfredo, Ribeiro da Cunha, Luís Eduardo, Ferreira, Jr, Rui Seabra, Barraviera, Benedito, Quintas, Luis Eduardo M, Melo, Paulo A

“…Massive, Africanized honeybee attacks have increased in Brazil over the years. Humans and animals present local and systemic effects after envenomation, and…”
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Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations by Noël, François, Azalim, Pedro, do Monte, Fernando M., Quintas, Luis Eduardo M., Katz, Adriana, Karlish, Steven J.D.

“…Ouabain and digoxin are classical inhibitors of the Na+,K+-ATPase. In addition to their conventional uses as therapeutic agents or experimental tools there is…”
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Antagonistic anticancer effect of paclitaxel and digoxin combination by Pereira, Duane Gischewski, Rendeiro, Mariana Manzano, Cortes, Vanessa Faria, Barbosa, Leandro Augusto, Quintas, Luis Eduardo M.

“…Despite the growing interest in the antitumor effect of cardiotonic steroids, combination treatments with well‐established chemotherapy drugs like paclitaxel…”
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Heparin prevents the cytotoxic activity of Bothrops jararacussu and Apis mellifera venoms in renal cells by Teixeira-Cruz, Jhonatha M., Martins-Ferreira, Jainne, Monteiro-Machado, Marcos, Strauch, Marcelo A., de Moraes, João.Alfredo, Amaral, Luciana S., Valente, Raphael C., Melo, Paulo A., Quintas, Luis Eduardo M.

“…Envenomation by Bothrops snakes and Apis mellifera bee may imply systemic disorders which affect well-perfused organs such as kidneys, a process that can lead…”
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Isoproterenol induces an increase in muscle fiber size by the proliferation of Pax7‐positive cells and in a mTOR‐independent mechanism by Bastos, Úrsula Maria C., Andrade Rosa, Ivone, Teixeira, John D., Gonçalves, Graciele, Costa, Manoel L., Quintas, Luis Eduardo M., Mermelstein, Claudia

“…β‐Adrenergic signaling regulates many physiological processes in skeletal muscles. A wealth of evidence has shown that β‐agonists can increase skeletal muscle…”
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Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules by Godinho, Alana N., Costa, Graciana T., Oliveira, Nádia O., Cardi, Bruno A., Uchoa, Daniel Esdras A., Silveira, Edilberto R., Quintas, Luis Eduardo M., Noël, François G., Fonteles, Manassés C., Carvalho, Krishnamurti M., Santos, Cláudia F., Lessa, Lucília M.A., do Nascimento, Nilberto R.F.

“…Cardiotonic steroids (CS) are known as modulators of sodium and water homeostasis. These compounds contribute to the excretion of sodium under overload…”
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Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation by Touza, Natália Araújo, Pôças, Elisa Suzana Carneiro, Quintas, Luis Eduardo M., Cunha-Filho, Geraldino, Santos, Maria Lucília, Noël, François

“…Cardiac glycosides have been extensively used in the treatment of congestive heart failure for more than 200years. Recently, cardenolides and bufadienolides…”
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γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect by Alves, Silmara L.G., Paixão, Natasha, Ferreira, Letícia G.R., Santos, Felipe R.S., Neves, Luiza D.R., Oliveira, Gisele C., Cortes, Vanessa F., Salomé, Kahlil S., Barison, Andersson, Santos, Fabio V., Cenzi, Gisele, Varotti, Fernando P., Oliveira, Soraya M.F., Taranto, Alex G., Comar, Moacyr, Silva, Luciana M., Noël, François, Quintas, Luis Eduardo M., Barbosa, Leandro A., Villar, José A.F.P.

“…[Display omitted] Cardiotonic steroids (CS), natural compounds with traditional use in cardiology, have been recently suggested to exert potent anticancer…”
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Different effects of myotoxins bothropstoxin-I and II from Bothrops snake venom on cation transport ATPases from murine fast twitch skeletal muscle by Ayres, Rodrigo, Feijó, Priscilla R.O., Cintra, Adelia C.O., Tomaz, Marcelo A., Melo, Paulo A., Cunha, Valéria M.N., Quintas, Luis Eduardo M.

“…Bothrops jararacussu venom drastically decreases sarcoplasmic Ca2+-ATPase (SERCA) protein expression in vivo and inhibits its activity in vitro, in contrast to…”
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Na +/K +-ATPase α isoforms expression in stroke-prone spontaneously hypertensive rat heart ventricles: Effect of salt loading and lacidipine treatment by Quintas, Luis Eduardo M., Noël, François, Wibo, Maurice

“…Changes in myocardial expression of Na +/K +-ATPase α-subunit isoforms have been demonstrated in different models of cardiac hypertrophy and hypertension. Here…”
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Mechanisms of adaptive supersensitivity in vas deferens by Quintas, Luis Eduardo M, Noël, François

“…Abstract Adaptive supersensitivity is a phenomenon characteristic of excitable tissues and discloses as a compensatory adjustment of tissue's response to…”
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Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection by Schaffazick, Naiara, Amaral, Luciana S., Fonseca, Tatiane F., Tomaz, Marcelo A., Gaban, Glauco A., Borges, Paula A., Calil-Elias, Sabrina, Noël, François, Melo, Paulo A., Quintas, Luis Eduardo M., Cunha, Valéria M.N.

“…Ca 2+ ions are essential to myonecrosis, a serious complication of snake envenomation, and heparin seems to counteract this effect. We investigated the effect…”
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Influence of development on Na +/K +-ATPase expression: isoform- and tissue-dependency by Lopez, Luciane B, Quintas, Luis Eduardo M, Noël, François

“…The four isoforms of the catalytic subunit of Na +/K +-ATPase identified in rats differ in their affinities for ions and ouabain. Moreover, its expression is…”
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Adaptive expression pattern of different proteins involved in cellular calcium homeostasis in denervated rat vas deferens by Quintas, Luis Eduardo M., Cunha, Valéria M.N., Scaramello, Christianne B.V., da Silva, Cláudia L.M., Caricati-Neto, Afonso, Lafayette, Simone S.L., Jurkiewicz, Aron, Noël, François

“…The activity and protein expression of plasma membrane and sarco(endo)plasmic reticulum (Ca 2+–Mg 2+)ATPases and ryanodine receptors were investigated in…”
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