Search Results - "QUINN, Peter J"
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Production of l-valine from metabolically engineered Corynebacterium glutamicum
Published in Applied microbiology and biotechnology (01-05-2018)“…l -Valine is one of the three branched-chain amino acids (valine, leucine, and isoleucine) essential for animal health and important in metabolism; therefore,…”
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PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
Published in Acta neuropathologica communications (09-11-2020)“…Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's…”
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Lipid–lipid interactions in bilayer membranes: Married couples and casual liaisons
Published in Progress in lipid research (01-07-2012)“…There is considerable interest in lateral domain structure in biological membranes not least because a variety of physiological processes are believed to…”
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Kdo2-lipid A: structural diversity and impact on immunopharmacology
Published in Biological reviews of the Cambridge Philosophical Society (01-05-2015)“…ABSTRACT 3‐deoxy‐d‐manno‐octulosonic acid‐lipid A (Kdo2‐lipid A) is the essential component of lipopolysaccharide in most Gram‐negative bacteria and the…”
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Metabolic engineering of Escherichia coli and Corynebacterium glutamicum for the production of l-threonine
Published in Biotechnology advances (2011)“…l-threonine is an essential amino acid for mammals and as such has a wide and expanding application in industry with a fast growing market demand. The major…”
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The effect of tocopherol on the structure and permeability of phosphatidylcholine liposomes
Published in Journal of controlled release (10-06-2012)“…There are numerous phospholipid formulations that incorporate α-tocopherol as a stabilizing agent but there are few studies of the effect of α-tocopherol on…”
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The Role of Small Molecules and Their Effect on the Molecular Mechanisms of Early Retinal Organoid Development
Published in International journal of molecular sciences (30-06-2021)“…Early embryonic retinal development is a well-documented and evolutionary conserved process. The specification towards eye development is temporally controlled…”
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Targeting miR-181a/b in retinitis pigmentosa: implications for disease progression and therapy
Published in Cell & bioscience (21-05-2024)“…Retinitis pigmentosa (RP) is a genetically heterogeneous group of degenerative disorders causing progressive vision loss due to photoreceptor death. RP affects…”
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Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur
Published in Antioxidants (01-08-2022)“…Neurodegenerative diseases are characterized by the progressive degeneration of the neuronal cells and their networks, hampering the function of the central or…”
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The partition of cholesterol between ordered and fluid bilayers of phosphatidylcholine: A synchrotron X-ray diffraction study
Published in Biochimica et biophysica acta (01-11-2007)“…The structure and composition of coexisting bilayer phases separated in binary mixtures of dipalmitoylphosphatidylcholine and cholesterol and ternary mixtures…”
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Egg-Sphingomyelin and Cholesterol Form a Stoichiometric Molecular Complex in Bilayers of Egg-Phosphatidylcholine
Published in The journal of physical chemistry. B (02-12-2010)“…Sphingomyelin and cholesterol are membrane lipids that interact to form liquid-ordered phase believed to act as a platform for the organization of signaling…”
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Lipopolysaccharide: Biosynthetic pathway and structure modification
Published in Progress in lipid research (01-04-2010)“…Lipopolysaccharide that constitutes the outer leaflet of the outer membrane of most Gram-negative bacteria is referred to as an endotoxin. It is comprised of a…”
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Hydrocarbon chains dominate coupling and phase coexistence in bilayers of natural phosphatidylcholines and sphingomyelins
Published in Biochimica et biophysica acta (01-05-2009)“…The structure and thermotropic phase behaviour of aqueous dispersions of egg phosphatidylcholine, egg sphingomyelin, bovine brain sphingomyelin and binary…”
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Comparison of the liquid-ordered bilayer phases containing cholesterol or 7-dehydrocholesterol in modeling Smith-Lemli-Opitz syndrome[S]
Published in Journal of lipid research (01-07-2010)“…The phase behavior of egg sphingomyelin (ESM) mixtures with cholesterol or 7-dehydrocholesterol (7-DHC) has been investigated by independent methods:…”
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The role of sphingomyelin in regulating phase coexistence in complex lipid model membranes: Competition between ceramide and cholesterol
Published in Biochimica et biophysica acta (01-12-2008)“…The structure, thermotropic phase behavior, dynamic motion and order parameters of bilayer dispersions of egg phosphatidylcholine, egg sphingomyelin, egg…”
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Isolation at physiological temperature of detergent-resistant membranes with properties expected of lipid rafts: the influence of buffer composition
Published in Biochemical journal (15-01-2009)“…The failure of most non-ionic detergents to release patches of DRM (detergent-resistant membrane) at 37 degrees C undermines the claim that DRMs consist of…”
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TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status
Published in Antioxidants (01-02-2023)“…Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment…”
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A lipid matrix model of membrane raft structure
Published in Progress in lipid research (01-10-2010)“…Domains in cell membranes are created by lipid–lipid interactions and are referred to as membrane rafts. Reliable isolation methods have been developed which…”
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Calcium-mediated binding of DNA to 1,2-distearoyl-sn-glycero-3-phosphocholine-containing mixed lipid monolayers
Published in Soft matter (01-01-2014)“…The calcium-mediated interaction of DNA with monolayers of the non-toxic, zwitterionic phospholipid, 1,2-distearoyl-sn-glycero-3-phosphocholine when mixed with…”
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Sphingolipid symmetry governs membrane lipid raft structure
Published in Biochimica et biophysica acta (01-07-2014)“…Lipid domain formation in membranes underlies the concept of rafts but their structure is controversial because the key role of cholesterol has been…”
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