Search Results - "QUIJADA, Pearl"

The Role of the Epicardium During Heart Development and Repair by Quijada, Pearl, Trembley, Michael A., Small, Eric M.

“…The heart is lined by a single layer of mesothelial cells called the epicardium that provides important cellular contributions for embryonic heart formation…”
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Coordination of endothelial cell positioning and fate specification by the epicardium by Quijada, Pearl, Trembley, Michael A., Misra, Adwiteeya, Myers, Jacquelyn A., Baker, Cameron D., Pérez-Hernández, Marta, Myers, Jason R., Dirkx, Ronald A., Cohen, Ethan David, Delmar, Mario, Ashton, John M., Small, Eric M.

“…The organization of an integrated coronary vasculature requires the specification of immature endothelial cells (ECs) into arterial and venous fates based on…”
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Cardiomyocyte cell cycle dynamics and proliferation revealed through cardiac-specific transgenesis of fluorescent ubiquitinated cell cycle indicator (FUCCI) by Alvarez, Roberto, Wang, Bingyan J., Quijada, Pearl J., Avitabile, Daniele, Ho, Thi, Shaitrit, Maya, Chavarria, Monica, Firouzi, Fareheh, Ebeid, David, Monsanto, Megan M., Navarrete, Natalie, Moshref, Maryam, Siddiqi, Sailay, Broughton, Kathleen M., Bailey, Barbara A., Gude, Natalie A., Sussman, Mark A.

“…Understanding and manipulating the cardiomyocyte cell cycle has been the focus of decades of research, however the ultimate goal of activating mitotic activity…”
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Myocardial AKT: the omnipresent nexus by Sussman, Mark A, Völkers, Mirko, Fischer, Kimberlee, Bailey, Brandi, Cottage, Christopher T, Din, Shabana, Gude, Natalie, Avitabile, Daniele, Alvarez, Roberto, Sundararaman, Balaji, Quijada, Pearl, Mason, Matt, Konstandin, Mathias H, Malhowski, Amy, Cheng, Zhaokang, Khan, Mohsin, McGregor, Michael

“…One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned…”
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Cardiac pericytes mediate the remodeling response to myocardial infarction by Quijada, Pearl, Park, Shuin, Zhao, Peng, Kolluri, Kamal Ss, Wong, David, Shih, Kevin D, Fang, Kai, Pezhouman, Arash, Wang, Lingjun, Daraei, Ali, Tran, Matthew D, Rathbun, Elle M, Burgos Villar, Kimberly N, Garcia-Hernandez, Maria L, Pham, Thanh Td, Lowenstein, Charles J, Iruela-Arispe, M Luisa, Carmichael, S Thomas, Small, Eric M, Ardehali, Reza

“…Despite the prevalence of pericytes in the microvasculature of the heart, their role during ischemia-induced remodeling remains unclear. We used multiple…”
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Enhancement of Myocardial Regeneration Through Genetic Engineering of Cardiac Progenitor Cells Expressing Pim-1 Kinase by FISCHER, Kimberlee M, COTTAGE, Christopher T, WEITAO WU, SHABANA DIN, GUDE, Natalie A, AVITABILE, Daniele, QUIJADA, Pearl, COLLINS, Brett L, FRANSIOLI, Jenna, SUSSMAN, Mark A

“…Despite numerous studies demonstrating the efficacy of cellular adoptive transfer for therapeutic myocardial regeneration, problems remain for donated cells…”
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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation by Din, Shabana, Mason, Matthew, Völkers, Mirko, Johnson, Bevan, Cottage, Christopher T., Wang, Zeping, Joyo, Anya Y., Quijada, Pearl, Erhardt, Peter, Magnuson, Nancy S., Konstandin, Mathias H., Sussman, Mark A.

“…Mitochondrial morphological dynamics affect the outcome of ischemic heart damage and pathogenesis. Recently, mitochondrial fission protein dynamin-related…”
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Mechanistic Target of Rapamycin Complex 2 Protects the Heart From Ischemic Damage by Völkers, Mirko, Konstandin, Mathias H, Doroudgar, Shirin, Toko, Haruhiro, Quijada, Pearl, Din, Shabana, Joyo, Anya, Ornelas, Luis, Samse, Kaitleen, Thuerauf, Donna J, Gude, Natalie, Glembotski, Christopher C, Sussman, Mark A

“…BACKGROUND—The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2)…”
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Cardiac Stem Cell Hybrids Enhance Myocardial Repair by Quijada, Pearl, Salunga, Hazel T, Hariharan, Nirmala, Cubillo, Jonathan D, El-Sayed, Farid G, Moshref, Maryam, Bala, Kristin M, Emathinger, Jacqueline M, De La Torre, Andrea, Ormachea, Lucia, Alvarez, Roberto, Gude, Natalie A, Sussman, Mark A

“…RATIONALE:Dual cell transplantation of cardiac progenitor cells (CPCs) and mesenchymal stem cells (MSCs) after infarction improves myocardial repair and…”
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Fibronectin Is Essential for Reparative Cardiac Progenitor Cell Response After Myocardial Infarction by Konstandin, Mathias H, Toko, Haruhiro, Gastelum, Grady M, Quijada, Pearl, De La Torre, Andrea, Quintana, Mercedes, Collins, Brett, Din, Shabana, Avitabile, Daniele, Völkers, Mirko, Gude, Natalie, Fässler, Reinhard, Sussman, Mark A

“…RATIONALE:Adoptive transfer of cardiac progenitor cells (CPCs) has entered clinical application, despite limited mechanistic understanding of the endogenous…”
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Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1 by Völkers, Mirko, Toko, Haruhiro, Doroudgar, Shirin, Din, Shabana, Quijada, Pearl, Joyo, Anya Y., Ornelas, Luis, Joyo, Eri, Thuerauf, Donna J., Konstandin, Mathias H., Gude, Natalie, Glembotski, Christopher C., Sussman, Mark A.

“…Mechanistic target of rapamycin complex 1 (mTORC1), necessary for cellular growth, is regulated by intracellular signaling mediating inhibition of mTORC1…”
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Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling by Ebeid, David E, Khalafalla, Farid G, Broughton, Kathleen M, Monsanto, Megan M, Esquer, Carolina Y, Sacchi, Veronica, Hariharan, Nirmala, Korski, Kelli I, Moshref, Maryam, Emathinger, Jacqueline, Cottage, Christopher T, Quijada, Pearl J, Nguyen, Jonathan H, Alvarez, Roberto, Völkers, Mirko, Konstandin, Mathias H, Wang, Bingyan J, Firouzi, Fareheh, Navarrete, Julian M, Gude, Natalie A, Goumans, Marie-Jose, Sussman, Mark A

“…Abstract Aims Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic…”
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Human Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair by Mohsin, Sadia, PhD, Khan, Mohsin, PhD, Toko, Haruhiro, MD, PhD, Bailey, Brandi, PhD, Cottage, Christopher T., MS, Wallach, Kathleen, BS, Nag, Divya, Lee, Andrew, BS, Siddiqi, Sailay, MD, Lan, Feng, PhD, Fischer, Kimberlee M., PhD, Gude, Natalie, PhD, Quijada, Pearl, MS, Avitabile, Daniele, PhD, Truffa, Silvia, BS, Collins, Brett, BS, Dembitsky, Walter, MD, Wu, Joseph C., MD, PhD, Sussman, Mark A., PhD

“…Objectives The goal of this study was to demonstrate the enhancement of human cardiac progenitor cell (hCPC) reparative and regenerative potential by genetic…”
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Activation of Notch-Mediated Protective Signaling in the Myocardium by Gude, Natalie A, Emmanuel, Gregory, Wu, Weitao, Cottage, Christopher T, Fischer, Kimberlee, Quijada, Pearl, Muraski, John A, Alvarez, Roberto, Rubio, Marta, Schaefer, Eric, Sussman, Mark A

“…The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and…”
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S100A4 protects the myocardium against ischemic stress by Doroudgar, Shirin, PhD, Quijada, Pearl, PhD, Konstandin, Mathias, MD, Ilves, Kelli, BS, Broughton, Kathleen, PhD, Khalafalla, Farid G., PhD, Casillas, Alexandria, Nguyen, Kristine, Gude, Natalie, PhD, Toko, Haruhiro, MD, Ornelas, Luis, BS, Thuerauf, Donna J., MS, Glembotski, Christopher C., PhD, Sussman, Mark A., PhD, Völkers, Mirko, MD

“…Abstract Background Myocardial infarction is followed by cardiac dysfunction, cellular death, and ventricular remodeling, including tissue fibrosis. S100A4…”
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Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy by Trembley, Michael A, Quijada, Pearl, Agullo-Pascual, Esperanza, Tylock, Kevin M, Colpan, Mert, Dirkx, Ronald A, Myers, Jason R, Mickelsen, Deanne M, de Mesy Bentley, Karen, Rothenberg, Eli, Moravec, Christine S, Alexis, Jeffrey D, Gregorio, Carol C, Dirksen, Robert T, Delmar, Mario, Small, Eric M

“…BACKGROUND:Hypertrophic cardiomyocyte growth and dysfunction accompany various forms of heart disease. The mechanisms responsible for transcriptional changes…”
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Nucleostemin Rejuvenates Cardiac Progenitor Cells and Antagonizes Myocardial Aging by Hariharan, Nirmala, PhD, Quijada, Pearl, MS, Mohsin, Sadia, PhD, Joyo, Anya, BS, Samse, Kaitlen, BS, Monsanto, Megan, BS, De La Torre, Andrea, BS, Avitabile, Daniele, PhD, Ormachea, Lucia, BS, McGregor, Michael J., MS, Tsai, Emily J., MD, Sussman, Mark A., PhD

“…Abstract Background Functional decline in stem cell–mediated regeneration contributes to aging associated with cellular senescence in c-kit+ cardiac progenitor…”
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PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity by Völkers, Mirko, Doroudgar, Shirin, Nguyen, Nathalie, Konstandin, Mathias H, Quijada, Pearl, Din, Shabana, Ornelas, Luis, Thuerauf, Donna J, Gude, Natalie, Friedrich, Kilian, Herzig, Stephan, Glembotski, Christopher C, Sussman, Mark A

“…Diabetes is a multi‐organ disease and diabetic cardiomyopathy can result in heart failure, which is a leading cause of morbidity and mortality in diabetic…”
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PIM1-minicircle as a therapeutic treatment for myocardial infarction by Liu, Nan, Wang, Bingyan J, Broughton, Kathleen M, Alvarez, Roberto, Siddiqi, Sailay, Loaiza, Rebeca, Nguyen, Nicky, Quijada, Pearl, Gude, Natalie, Sussman, Mark A

“…PIM1, a pro-survival gene encoding a serine/ threonine kinase, influences cell proliferation and survival. Modification of cardiac progenitor cells (CPCs) or…”
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Notch activation enhances lineage commitment and protective signaling in cardiac progenitor cells by Gude, Natalie, Joyo, Eri, Toko, Haruhiro, Quijada, Pearl, Villanueva, Marlo, Hariharan, Nirmala, Sacchi, Veronica, Truffa, Silvia, Joyo, Anya, Voelkers, Mirko, Alvarez, Roberto, Sussman, Mark A.

“…Phase I clinical trials applying autologous progenitor cells to treat heart failure have yielded promising results; however, improvement in function is modest,…”
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