Search Results - "QUIGLEY, J P"

In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated β1 integrin and induction of FAK/PI3K/Akt motility signaling by Casar, B, Rimann, I, Kato, H, Shattil, S J, Quigley, J P, Deryugina, E I

“…Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1 (CDCP1), by plasmin-like serine proteases induces outside–in signal…”
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In vivo cleaved CDCP1 promotes early tumor dissemination via complexing with activated beta 1 integrin and induction of FAK/PI3K/Akt motility signaling by Casar, B, Rimann, I, Kato, H, Shattil, S J, Quigley, J P, Deryugina, E I

“…Specific cleavage of the transmembrane molecule, CUB domain-containing protein-1 (CDCP1), by plasmin-like serine proteases induces outside-in signal…”
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PAI-1, fibrosis, and the elusive provisional fibrin matrix by Loskutoff, D J, Quigley, J P

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Growth factor–induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen by Seandel, Marco, Noack-Kunnmann, Katharina, Zhu, Dan, Aimes, Ronald T., Quigley, James P.

“…The contribution of specific type I collagen remodeling in angiogenesis was studied in vivo using a quantitative chick embryo assay that measures new blood…”
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Interleukin-1 beta regulates human cytotrophoblast metalloproteinase activity and invasion in vitro by LIBRACH, C. L, FEIGENBAUM, S. L, BASS, K. E, TIAN-YI CUI, VERASTAS, N, SADOVSKY, Y, QUIGLEY, J. P, FRENCH, D. L, FISHER, S. J

“…During early human pregnancy, fetal cytotrophoblasts rapidly invade the uterus. This process has many similarities to tumor invasion, except that the extent…”
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Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis by TESTA, J. E, BROOKS, P. C, LIN, J.-M, QUIGLEY, J. P

“…A monoclonal antibody (mAb), 50-6, generated by subtractive immunization, was found to specifically inhibit in vivo metastasis of a human epidermoid carcinoma…”
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Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival and inhibits metastatic colonization through PARP1-mediated apoptosis of cancer cells by Casar, B, He, Y, Iconomou, M, Hooper, J D, Quigley, J P, Deryugina, E I

“…The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule that has recently been implicated in cancer progression. In this study we have…”
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The role of urokinase-type plasminogen activator in aggressive tumor cell behavior by TESTA, J. E, QUIGLEY, J. P

“…The correlation between urokinase-type plasminogen activator (uPA) expression and tumor cell invasion and metastasis has been well documented. Urokinase…”
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Matrix metalloproteinases and tumor metastasis by Deryugina, Elena I, Quigley, James P

“…Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor cells and stromal cells, are finely regulated by their spatial as…”
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Doppler echocardiographic detection of left ventricular diastolic dysfunction in patients with pulmonary sarcoidosis by Fahy, G J, Marwick, T, McCreery, C J, Quigley, P J, Maurer, B J

“…To determine the prevalence of left ventricular diastolic dysfunction in patients with biopsy specimen-proved pulmonary sarcoidosis without clinical evidence…”
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Limited Cleavage of Cellular Fibronectin by Plasminogen Activator Purified from Transformed Cells by Quigley, James P., Gold, Leslie I., Schwimmer, Randi, Sullivan, Lee M.

“…The substrate specificity and direct catalytic activity of plasminogen activator (PA) was examined under conditions where its natural substrate, plasminogen,…”
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Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes by Hooper, J D, Clements, J A, Quigley, J P, Antalis, T M

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Cloning of a 72 kDa matrix metalloproteinase (gelatinase) from chicken embryo fibroblasts using gene family PCR: expression of the gelatinase increases upon malignant transformation by Aimes, R.T, French, D.L, Quigley, J.P

“…Chicken embryo fibroblasts secrete a 72 kDa progelatinase that displays all of the characteristics of a matrix metalloproteinase. Employing…”
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Activation of Matrix Metalloproteinase-9 (MMP-9) via a Converging Plasmin/Stromelysin-1 Cascade Enhances Tumor Cell Invasion by Ramos-DeSimone, Noemi, Hahn-Dantona, Elizabeth, Sipley, John, Nagase, Hideaki, French, Deborah L., Quigley, James P.

“…Matrix metalloproteinase-9 (MMP-9) may play a critical catalytic role in tissue remodeling in vivo, but it is secreted by cells as a stable, inactive zymogen,…”
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Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 by Brooks, P C, Strömblad, S, Sanders, L C, von Schalscha, T L, Aimes, R T, Stetler-Stevenson, W G, Quigley, J P, Cheresh, D A

“…Cellular invasion depends on cooperation between adhesive and proteolytic mechanisms. Evidence is provided that the matrix metalloproteinase MMP-2 can be…”
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A role for protease inhibitors in immunity of long-lived animals by Armstrong, P B, Quigley, J P

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Human plasma fibronectin as a substrate for human urokinase by Gold, L I, Schwimmer, R, Quigley, J P

“…An early event in malignant transformation is the increased expression of proteases, such as plasminogen activator, which can degrade surrounding extracellular…”
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The Extracellular Matrix of Normal Chick Embryo Fibroblasts: Its Effect on Transformed Chick Fibroblasts and Its Proteolytic Degradation by the Transformants by Fairbairn, Sandra, Gilbert, Rhonda, Ojakian, George, Schwimmer, Randi, Quigley, James P.

“…Extracellular matrix (ECM), prepared from chick embryo fibroblasts, contains fibronectin as the major structural protein along with collagen and other…”
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Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells by Rozanov, D V, Deryugina, E I, Ratnikov, B I, Monosov, E Z, Marchenko, G N, Quigley, J P, Strongin, A Y

“…Membrane type-1 matrix metalloproteinase (MT1-MMP) is a key enzyme in the activation pathway of matrix prometalloproteinase-2 (pro-MMP-2). Both activation and…”
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Subtractive immunization using highly metastatic human tumor cells identifies SIMA135 CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen by HOOPER, John D, ZIJLSTRA, Andries, AIMES, Ronald T, HONGYAN LIANG, CLAASSEN, Gisela F, TARIN, David, TESTA, Jacqueline E, QUIGLEY, James P

“…We have previously used a subtractive immunization (SI) approach to generate monoclonal antibodies (mAbs) against proteins preferentially expressed by the…”
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