Search Results - "QUEVEDO, Joao"
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1
The conundrum of antidepressant use in bipolar disorder
Published in Molecular psychiatry (01-03-2023)Get full text
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2
Impact of COVID-19 in the Mental Health in Elderly: Psychological and Biological Updates
Published in Molecular neurobiology (01-05-2021)“…Since December 2019, the world has been experiencing the challenge of facing coronavirus disease-19 (COVID-19), a severe infectious disease caused by the new…”
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Deep brain stimulation of the “medial forebrain bundle”: a strategy to modulate the reward system and manage treatment-resistant depression
Published in Molecular psychiatry (01-01-2022)“…The medial forebrain bundle—a white matter pathway projecting from the ventral tegmental area—is a structure that has been under a lot of scrutinies recently…”
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4
Mitophagy in depression: Pathophysiology and treatment targets
Published in Mitochondrion (01-11-2021)“…•Mitochondrial dysfunction has been implicated in the pathophysiology of depression.•Mitophagy selectively removes defective mitochondria through…”
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5
Are microglia in charge of controlling stress-response behavior?
Published in Molecular psychiatry (01-08-2024)Get full text
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A systematic review of evidence for the role of inflammatory biomarkers in bipolar patients
Published in Journal of psychiatric research (01-09-2017)“…Bipolar disorder (BD) is a neuropsychiatric disorder that is characterized by a phasic course of affective episodes interspersed with a euthymic state…”
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7
Did we finally find a good animal model for bipolar disorder?
Published in Molecular psychiatry (01-07-2023)Get full text
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TSPO upregulation in bipolar disorder and concomitant downregulation of mitophagic proteins and NLRP3 inflammasome activation
Published in Neuropsychopharmacology (New York, N.Y.) (01-06-2019)“…Bipolar disorder (BD) is a chronic, debilitating illness with a global prevalence of up to 4.8%. The importance of understanding how dysfunctional mitochondria…”
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9
The role of microglia activation in the development of sepsis-induced long-term cognitive impairment
Published in Brain, behavior, and immunity (01-01-2015)“…Abstract Oxidative stress and inflammation is likely to be a major step in the development of sepsis-associated encephalopathy (SAE) and long-term cognitive…”
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Physical Exercise and Neuroinflammation in Major Depressive Disorder
Published in Molecular neurobiology (01-12-2019)“…Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied prognosis, chronic course, and duration of illness with reduced…”
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Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder
Published in Advances in experimental medicine and biology (2023)“…Bipolar disorder (BD) is a severe and chronic psychiatric disorder that affects approximately 1-4% of the world population and is characterized by recurrent…”
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Animal models as tools to study the pathophysiology of depression
Published in Revista brasileira de psiquiatria (2013)“…The incidence of depressive illness is high worldwide, and the inadequacy of currently available drug treatments contributes to the significant health burden…”
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13
Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
Published in Neuropsychopharmacology (New York, N.Y.) (01-05-2011)“…Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. Cannabidiol (CBD), one major…”
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The renin–angiotensin system : a possible new target for depression
Published in BMC medicine (01-08-2017)“…This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which…”
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The prevalence, risk factors and clinical correlates of obesity in Chinese patients with schizophrenia
Published in Psychiatry research (01-05-2017)“…Abstract Obesity is a common comorbidity in schizophrenia. Few studies have addressed obesity in Chinese schizophrenia patients. The aims of this current study…”
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Major depressive disorder as a neuro-immune disorder: Origin, mechanisms, and therapeutic opportunities
Published in Neuroscience and biobehavioral reviews (01-12-2023)“…Notwithstanding advances in understanding the pathophysiology of major depressive disorder (MDD), no single mechanism can explain all facets of this disorder…”
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Requirement of brain interleukin33 for aquaporin4 expression in astrocytes and glymphatic drainage of abnormal tau
Published in Molecular psychiatry (01-10-2021)“…Defective aquaporin4 (AQP4)-mediated glymphatic drainage has been linked to tauopathy and amyloid plaque in Alzheimer’s disease. We now show that brain…”
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Microglial Cells Depletion Increases Inflammation and Modifies Microglial Phenotypes in an Animal Model of Severe Sepsis
Published in Molecular neurobiology (01-11-2019)“…Sepsis-associated encephalopathy is highly prevalent and has impact both in early and late morbidity and mortality. The mechanisms by which sepsis induces…”
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Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia
Published in European neuropsychopharmacology (01-03-2018)“…Metabolic syndrome (MetS) is seen more frequently in persons with schizophrenia than in the general population, and these metabolic abnormalities are further…”
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The role of DNA methylation in the pathophysiology and treatment of bipolar disorder
Published in Neuroscience and biobehavioral reviews (01-09-2016)“…•DNA methylation is a stable epigenetic modification that can alter gene expression.•DNA methylation might partly account for BD heritability.•Several…”
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