Search Results - "QUARLES, L. D"

Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone by Liu, Shiguang, Tang, Wen, Fang, Jianwen, Ren, Jinyu, Li, Hua, Xiao, Zhousheng, Quarles, L. D

“…We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts associated with abnormal Fgf23 production and mineralization in Hyp…”
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Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics by Goodman, William G., Quarles, L.D.

“…The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as the major regulator of parathyroid gland function have important…”
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Pathogenic role of Fgf23 in Dmp1-null mice by Liu, Shiguang, Zhou, Jianping, Tang, Wen, Menard, Rochelle, Feng, Jian Q, Quarles, L D

“…Autosomal recessive hypophosphatemic rickets (ARHR), which is characterized by renal phosphate wasting, aberrant regulation of 1alpha-hydroxylase activity, and…”
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Overexpression of the DMP1 C-Terminal Fragment Stimulates FGF23 and Exacerbates the Hypophosphatemic Rickets Phenotype in Hyp Mice by Martin, A, David, V, Li, H, Dai, B, Feng, J. Q, Quarles, L. D

“…Dentin matrix protein-1 (DMP1) or phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) inactivation results in elevation of…”
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Role of the polycytin-primary cilia complex in bone development and mechanosensing by Xiao, Z.S., Quarles, L.D.

“…Pkd1 encodes PC1, a transmembrane receptor‐like protein, and Pkd2 encodes PC2, a calcium channel, which interact to form functional polycystin complexes that…”
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MEPE has the properties of an osteoblastic phosphatonin and minhibin by Rowe, P.S.N, Kumagai, Y, Gutierrez, G, Garrett, I.R, Blacher, R, Rosen, D, Cundy, J, Navvab, S, Chen, D, Drezner, M.K, Quarles, L.D, Mundy, G.R

“…Matrix extracellular phosphoglycoprotein (MEPE) is expressed exclusively in osteoblasts, osteocytes and odontoblasts with markedly elevated expression found in…”
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Analysis of recombinant Phex: an endopeptidase in search of a substrate by Guo, R, Liu, S, Spurney, R F, Quarles, L D

“…X-linked hypophosphatemia (XLH) is caused by inactivating mutations of Phex, a phosphate-regulating endopeptidase. Further advances in our knowledge of the…”
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Fibroblast growth factor-23: what we know, what we don't know, and what we need to know by Kovesdy, Csaba P, Quarles, Leigh Darryl

“…Traditional risk factors of cardiovascular morbidity and mortality such as hypertension, hypercholesterolemia and obesity are paradoxically associated with…”
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Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis by Xiao, Zhou-Sheng, Hjelmeland, Anita B, Quarles, L D

“…Runx2 (runt-related transcription factor 2) is a master regulator of skeletogenesis. Distinct promoters in the Runx2 gene transcribe the "bone-related"…”
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Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia by Quarles, L D, Lobaugh, B, Murphy, G

“…To examine the possibility that uremia alters the relationship between bioactive PTH serum concentrations and its osseous end-organ response, we evaluated the…”
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Cinacalcet reduces plasma intact parathyroid hormone, serum phosphate and calcium levels in patients with secondary hyperparathyroidism irrespective of its severity by Frazão, J M, Messa, P, Mellotte, G J, Geiger, H, Hagen, E C, Quarles, L D, Kerr, P G, Baños, A, Dehmel, B, Urena, P

“…To evaluate the relationship between the severity of secondary hyperparathyroidism (SHPT) - defined in terms of baseline plasma intact parathyroid hormone…”
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Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone by Liu, Shiguang, Tang, Wen, Fang, Jianwen, Ren, Jinyu, Li, Hua, Xiao, Zhousheng, Quarles, L. D

“…We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts associated with abnormal Fgf23 production and mineralization in Hyp…”
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Intrinsic mineralization defect in Hyp mouse osteoblasts by Xiao, Z S, Crenshaw, M, Guo, R, Nesbitt, T, Drezner, M K, Quarles, L D

“…X-linked hypophosphatemia (XLH) is caused by inactivating mutations of PEX, an endopeptidase of uncertain function. This defect is shared by Hyp mice, the…”
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Characterization of the upstream mouse Cbfa1/Runx2 promoter by Xiao, Z. S., Liu, Shi-Guang, Hinson, T. K., Quarles, L. D.

“…Cbfa1 (or Runx2/AML‐3/PEPB2α) is a transcriptional activator of osteoblastic differentiation. To investigate the regulation of Cbfa1 expression, we isolated…”
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Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation by Dai, Z., Li, Y., Quarles, L.D., Song, T., Pan, W., Zhou, H., Xiao, Z.

“…In the present study, we investigated the in vitro effect of resveratrol (RSVL), a polyphenolic phytoestrogen, on cell proliferation and osteoblastic…”
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Cation Sensing Receptors in Bone: A Novel Paradigm for Regulating Bone Remodeling? by Quarles, L. Darryl

“…BONE UNDERGOES a remodeling process consisting of osteoblast-mediated bone formation coupled to osteoclastic resorption of bone. This regenerative process…”
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Preventing bone loss after renal transplantation with bisphosphonates: We can… but should we? by Weber, Thomas J., Quarles, L. Darryl

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Cbfa1 isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and pre-osteoblastic cells by Xiao, Z.S., Hinson, T.K., Quarles, L.D.

“…The mouse Cbfa1 gene potentially encodes several proteins that differ in their N‐terminal sequences, including an osteoblast‐specific transcription factor,…”
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Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor by Xiao, Z.S, Thomas, R, Hinson, T.K, Quarles, L.D

“…Although the CBFA1 gene encodes an osteoblast-specific transcription factor that regulates osteoblast differentiation, uncertainty exists about the…”
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Cloning and Sequencing of Human PEX from a Bone cDNA Library: Evidence for Its Developmental Stage‐Specific Regulation in Osteoblasts by Guo, Rong, Quarles, L. Darryl

“…Inactivating mutations of the neutral endopeptidase, PEX, have been identified as the cause of X‐linked hypophosphatemia (XLH). Though the function of PEX is…”
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