Search Results - "QUANZ, Maria"

Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance by Quanz, Maria, Bender, Eckhard, Kopitz, Charlotte, Grünewald, Sylvia, Schlicker, Andreas, Schwede, Wolfgang, Eheim, Ashley, Toschi, Luisella, Neuhaus, Roland, Richter, Carmen, Toedling, Joern, Merz, Claudia, Lesche, Ralf, Kamburov, Atanas, Siebeneicher, Holger, Bauser, Marcus, Hägebarth, Andrea

“…The lactate transporter /monocarboxylate transporter 1 (MCT1) plays a central role in tumor cell energy homeostasis. In a cell-based screen, we identified a…”
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Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target by Ellermann, Manuel, Eheim, Ashley, Rahm, Fredrik, Viklund, Jenny, Guenther, Judith, Andersson, Martin, Ericsson, Ulrika, Forsblom, Rickard, Ginman, Tobias, Lindström, Johan, Silvander, Camilla, Trésaugues, Lionel, Giese, Anja, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Bauser, Marcus, Haegebarth, Andrea, Gorjánácz, Mátyás

“…MTH1 is a hydrolase responsible for sanitization of oxidized purine nucleoside triphosphates to prevent their incorporation into replicating DNA. Early tool…”
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Hyperactivation of DNA-PK by double-strand break mimicking molecules disorganizes DNA damage response by Quanz, Maria, Chassoux, Danielle, Berthault, Nathalie, Agrario, Céline, Sun, Jian-Sheng, Dutreix, Marie

“…Cellular response to DNA damage involves the coordinated activation of cell cycle checkpoints and DNA repair. The early steps of DNA damage recognition and…”
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A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma by Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie

“…Abstract Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break…”
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DNA-PK target identification reveals novel links between DNA repair signaling and cytoskeletal regulation by Kotula, Ewa, Faigle, Wolfgang, Berthault, Nathalie, Dingli, Florent, Loew, Damarys, Sun, Jian-Sheng, Dutreix, Marie, Quanz, Maria

“…The DNA-dependent protein kinase (DNA-PK) may function as a key signaling kinase in various cellular pathways other than DNA repair. Using a two-dimensional…”
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Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A by Friberg, Anders, Rehwinkel, Hartmut, Nguyen, Duy, Pütter, Vera, Quanz, Maria, Weiske, Jörg, Eberspächer, Uwe, Heisler, Iring, Langer, Gernot

“…Lactate dehydrogenase A (LDHA) is frequently overexpressed in tumors, thereby sustaining high glycolysis rates, tumor growth, and chemoresistance…”
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Small-Molecule Drugs Mimicking DNA Damage: A New Strategy for Sensitizing Tumors to Radiotherapy by QUANZ, Maria, BERTHAULT, Nathalie, COSSET, Jean-Marc, LARUE, Lionel, SUN, Jian-Sheng, DUTREIX, Marie, ROULIN, Christophe, ROY, Maryline, HERBETTE, Aurélie, AGRARIO, Celine, ALBERTI, Christophe, JOSSERAND, Véronique, COLL, Jean-Luc, SASTRE-GARAU, Xavier

“…Purpose: Enhanced DNA repair activity is often associated with tumor resistance to radiotherapy. We hypothesized that inhibiting DNA damage repair would…”
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Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models by Quanz, Maria, Hagemann, Urs B, Zitzmann-Kolbe, Sabine, Stelte-Ludwig, Beatrix, Golfier, Sven, Elbi, Cem, Mumberg, Dominik, Ziegelbauer, Karl, Schatz, Christoph A

“…Despite the recent advances in the treatment of ovarian cancer, it remains an area of high unmet medical need. Epithelial ovarian cancer is associated with…”
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Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci by Quanz, Maria, Herbette, Aurélie, Sayarath, Mano, de Koning, Leanne, Dubois, Thierry, Sun, Jian-Sheng, Dutreix, Marie

“…DNA damage triggers a complex signaling cascade involving a multitude of phosphorylation events. We found that the threonine 7 (Thr-7) residue of heat shock…”
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Kinesin KIFC1 actively transports bare double-stranded DNA by Farina, Francesca, Pierobon, Paolo, Delevoye, Cédric, Monnet, Jordan, Dingli, Florent, Loew, Damarys, Quanz, Maria, Dutreix, Marie, Cappello, Giovanni

“…During the past years, exogenous DNA molecules have been used in gene and molecular therapy. At present, it is not known how these DNA molecules reach the cell…”
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Abstract 1049: Pharmacological characterization of a novel potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with robust in vivo efficacy and increased therapeutic index with niacin supplementation by Quanz, Maria, Merz, Claudia, Bernthaler, Andreas, Kaulfuss, Stefan, Richter, Anja, Bauser, Marcus, Haegebarth, Andrea

“…Abstract Nicotinamide adenine dinucleotide (NAD+) is an important metabolite and cofactor for a number of cellular processes including genomic stability and…”
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Abstract 1780: Anetumab ravtansine has single-agent activity in mesothelin-expressing human ovarian cancer models and potentiates the activity of chemotherapeutics and targeted agents by Schatz, Christoph A., Quanz, Maria, Hagemann, Urs B., Zitzmann-Kolbe, Sabine, Stelte-Ludwig, Beatrix, Golfier, Sven, Kopitz, Charlotte, Elbi, Cem, Ziegelbauer, Karl, Mumberg, Dominik

“…Abstract Ovarian cancer remains an area of high unmet medical need, with 239,000 patients newly diagnosed per year. Here we describe the mesothelin-targeting…”
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Inhibition of DNA damage repair by artificial activation of PARP with siDNA by Croset, Amelie, Cordelières, Fabrice P, Berthault, Nathalie, Buhler, Cyril, Sun, Jian-Sheng, Quanz, Maria, Dutreix, Marie

“…One of the major early steps of repair is the recruitment of repair proteins at the damage site, and this is coordinated by a cascade of modifications…”
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Kinesin KIFC1 Actively Transports Double-Stranded DNA in Eukaryotic Cells by Farina, Francesca, Delevoye, Cédric, Dutreix, Marie, Quanz, Maria, Cappello, Giovanni

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Abstract 1807: Anti-tumor activity of a novel structural class of NAMPT inhibitor-based ADCs in models of hematologic and solid tumor indications by Sommer, Anette, Hammer, Stefanie, Berndt, Sandra, Wengner, Antje M., Boehnke, Niels, Berger, Markus, Griebenow, Nils, Steffen, Andreas, Stelte-Ludwig, Beatrix, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Joerissen, Hannah, Giese, Anja, Quanz, Maria, Bao, Zhengzheng, Wu, Xiuli, Weinmann, Hilmar, Linden, Lars, Kreft, Bertolt, Mumberg, Dominik

“…Abstract Nicotinamide phosphoribosyl-transferase (NAMPT) is the rate-limiting enzyme in the salvage pathway, generating nicotinamide adenine dinucleotide (NAD)…”
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Abstract 5226: Novel class of potent and selective inhibitors efface MTH1 as broad-spectrum cancer target by Ellermann, Manuel, Giese, Anja, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Jörg, Quanz, Maria, Glasauer, Andrea, Rahm, Fredrik, Viklund, Jenny, Andersson, Martin, Ginman, Tobias, Forsblom, Rickard, Lindström, Johan, Trésaugues, Lionel, Gorjanacz, Matyas

“…Abstract Malignant transformation is accompanied by increased reactive oxygen species (ROS) known to promote carcinogenesis and damage free nucleotides and…”
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Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1 by Bauser, Marcus, Giese, Anja, Ellermann, Manuel, Guenther, Judith, Eheim, Ashley, Bunse, Stefanie, Neuhaus, Roland, Weiske, Joerg, Quanz, Maria, Glasauer, Andrea, Nowak-Reppel, Katrin, Bader, Benjamin, Irlbacher, Horst, Meyer, Hanna, Queisser, Nina, Haegebarth, Andrea, Gorjanacz, Matyas, Tresaugues, Lionel, Ginman, Tobias, Rahm, Fredrik, Andersson, Martin, Ericsson, Ulrica, Forsblom, Rickard, Lindstroem, Johan, Silvander, Camilla, Vicklund, Jenny

“…Abstract Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular…”
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Abstract 1164: Metabolic responses in cancer cells with differential susceptibility to GLUT1 inhibition by Gruenewald, Sylvia, Rennefahrt, Ulrike, Maldonado, Sandra G., Walter, Alexander, Petrul, Heike, Héroult, Mélanie, Heisler, Iring, Quanz, Maria, Steigemann, Patrick, Buchmann, Bernd, Haegebarth, Andrea

“…Abstract Malignant cells are known for their accelerated metabolism, high energy requirements, and increased glucose uptake. They are characterized by high…”
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A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma1 by Biau, Julian, Devun, Flavien, Jdey, Wael, Kotula, Ewa, Quanz, Maria, Chautard, Emmanuel, Sayarath, Mano, Sun, Jian-Sheng, Verrelle, Pierre, Dutreix, Marie

“…Melanomas are highly radioresistant tumors, mainly due to efficient DNA double-strand break (DSB) repair. Dbait (which stands for DNA strand break bait)…”
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Abstract 1442: Effects of selective and broad glucose transporter (GLUT) inhibition on glucose distribution in tumor bearing mice by Heroult, Melanie, Steinke, Wolfram, Frisk, Anna-Lena, Borkowski, Sandra, Meyer, Kirstin, Petrul, Heike, Heisler, Iring, Quanz, Maria, Neuhaus, Roland, Buchmann, Bernd, Mueller, Thomas, Bauser, Marcus, Haegebarth, Andrea, Brands, Michael, Ziegelbauer, Karl

“…Abstract Malignant cells are known for their accelerated metabolism, high energy requirements, and increased glucose uptake. Transport of glucose across the…”
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